JP5647519B2 - 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 - Google Patents

重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 Download PDF

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JP5647519B2
JP5647519B2 JP2010524866A JP2010524866A JP5647519B2 JP 5647519 B2 JP5647519 B2 JP 5647519B2 JP 2010524866 A JP2010524866 A JP 2010524866A JP 2010524866 A JP2010524866 A JP 2010524866A JP 5647519 B2 JP5647519 B2 JP 5647519B2
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deuterated
composition
paroxetine
benzo
coor
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JP2010539166A5 (enExample
JP2010539166A (ja
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アンドリュー ディー． ジョーンズ，
アンドリュー ディー． ジョーンズ，
ロバート イー． ゼラ，
ロバート イー． ゼラ，
アイ． ロバート シルバーマン，
アイ． ロバート シルバーマン，
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コンサート ファーマシューティカルズ インコーポレイテッド
コンサート ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
JP2010524866A 2007-09-13 2008-09-12 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 Expired - Fee Related JP5647519B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99356507P 2007-09-13 2007-09-13
US60/993,565 2007-09-13
PCT/US2008/010643 WO2009035652A1 (en) 2007-09-13 2008-09-12 Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

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JP2010539166A JP2010539166A (ja) 2010-12-16
JP2010539166A5 JP2010539166A5 (enExample) 2012-11-01
JP5647519B2 true JP5647519B2 (ja) 2014-12-24

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US (2) US8822498B2 (enExample)
EP (2) EP2200997B9 (enExample)
JP (1) JP5647519B2 (enExample)
CN (1) CN101855218A (enExample)
AU (1) AU2008299921B2 (enExample)
CA (1) CA2698808A1 (enExample)
MX (1) MX2010002692A (enExample)
WO (1) WO2009035652A1 (enExample)

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JP5647519B2 (ja) 2007-09-13 2014-12-24 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成
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CN102924426B (zh) * 2012-11-14 2014-07-02 广西师范大学 胡椒乙胺缩5-氯水杨醛及其合成方法和应用
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CN110179792A (zh) * 2014-07-29 2019-08-30 深圳君圣泰生物技术有限公司 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用
WO2016109795A1 (en) 2014-12-31 2016-07-07 Concert Pharmaceuticals, Inc. Deuterated funapide and difluorofunapide
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CN108602786B (zh) 2016-02-25 2019-04-23 深圳市塔吉瑞生物医药有限公司 一种取代的噁二唑类化合物及包含该化合物的组合物及其用途
KR101970326B1 (ko) * 2016-08-05 2019-04-18 고려대학교 산학협력단 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물
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AU2008299921A1 (en) 2009-03-19
AU2008299921A8 (en) 2010-04-08
US8822498B2 (en) 2014-09-02
US20090143432A1 (en) 2009-06-04
WO2009035652A1 (en) 2009-03-19
US20140336387A1 (en) 2014-11-13
EP2200997B9 (en) 2016-01-13
EP2727915B1 (en) 2016-04-13
CN101855218A (zh) 2010-10-06
US9315483B2 (en) 2016-04-19
JP2010539166A (ja) 2010-12-16
MX2010002692A (es) 2010-06-01
EP2200997B1 (en) 2013-11-06
CA2698808A1 (en) 2009-03-19
EP2200997A1 (en) 2010-06-30
AU2008299921B2 (en) 2012-03-01
EP2727915A1 (en) 2014-05-07

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