AU2008299921B2 - Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof - Google Patents

Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof Download PDF

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Publication number
AU2008299921B2
AU2008299921B2 AU2008299921A AU2008299921A AU2008299921B2 AU 2008299921 B2 AU2008299921 B2 AU 2008299921B2 AU 2008299921 A AU2008299921 A AU 2008299921A AU 2008299921 A AU2008299921 A AU 2008299921A AU 2008299921 B2 AU2008299921 B2 AU 2008299921B2
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AU
Australia
Prior art keywords
deuterated
benzo
represented
nhc
paroxetine
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Ceased
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AU2008299921A
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AU2008299921A1 (en
AU2008299921A8 (en
Inventor
Andrew D. Jones
I. Robert Silverman
Robert E. Zelle
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Concert Pharmaceuticals Inc
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Concert Pharmaceuticals Inc
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Publication of AU2008299921A8 publication Critical patent/AU2008299921A8/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AU2008299921A 2007-09-13 2008-09-12 Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof Ceased AU2008299921B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99356507P 2007-09-13 2007-09-13
US60/993,565 2007-09-13
PCT/US2008/010643 WO2009035652A1 (en) 2007-09-13 2008-09-12 Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

Publications (3)

Publication Number Publication Date
AU2008299921A1 AU2008299921A1 (en) 2009-03-19
AU2008299921A8 AU2008299921A8 (en) 2010-04-08
AU2008299921B2 true AU2008299921B2 (en) 2012-03-01

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AU2008299921A Ceased AU2008299921B2 (en) 2007-09-13 2008-09-12 Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

Country Status (8)

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US (2) US8822498B2 (enExample)
EP (2) EP2727915B1 (enExample)
JP (1) JP5647519B2 (enExample)
CN (1) CN101855218A (enExample)
AU (1) AU2008299921B2 (enExample)
CA (1) CA2698808A1 (enExample)
MX (1) MX2010002692A (enExample)
WO (1) WO2009035652A1 (enExample)

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EP1948646A2 (en) * 2005-11-14 2008-07-30 Auspex Pharmaceuticals Inc. Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
AU2008299921B2 (en) 2007-09-13 2012-03-01 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
ME03652B (me) * 2011-05-18 2020-07-20 Vertex Pharmaceuticals Europe Ltd Deuterisani derivati ivakaftora
US20120302526A1 (en) * 2011-05-27 2012-11-29 Regents Of The University Of Colorado, A Body Corporate Methods for treating post-traumatic stress disorder
CN102924426B (zh) * 2012-11-14 2014-07-02 广西师范大学 胡椒乙胺缩5-氯水杨醛及其合成方法和应用
CN102942554B (zh) * 2012-11-14 2014-05-28 广西师范大学 胡椒乙胺缩水杨醛及其合成方法和应用
RU2696492C2 (ru) 2014-05-13 2019-08-02 Ф. Хоффманн-Ля Рош Аг Дейтрированные гетероциклические соединения и их применение в качестве средств визуализации
CN104059030B (zh) * 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN103980271B (zh) * 2014-05-30 2015-12-02 天津长森药业有限公司 黄藤素及其类似物的制备方法
NZ728488A (en) * 2014-07-29 2023-03-31 Shenzhen Hightide Biopharmaceutical Ltd Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
WO2016109795A1 (en) 2014-12-31 2016-07-07 Concert Pharmaceuticals, Inc. Deuterated funapide and difluorofunapide
US10196384B2 (en) 2015-03-31 2019-02-05 Vertex Pharmaceuticals (Europe) Limited Deuterated CFTR modulators
WO2017053711A2 (en) 2015-09-25 2017-03-30 Concert Pharmaceuticals, Inc. Deuterated cftr potentiators
CN108602786B (zh) 2016-02-25 2019-04-23 深圳市塔吉瑞生物医药有限公司 一种取代的噁二唑类化合物及包含该化合物的组合物及其用途
KR101970326B1 (ko) * 2016-08-05 2019-04-18 고려대학교 산학협력단 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN111479804B (zh) 2017-12-01 2023-12-22 弗特克斯药品有限公司 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
CN113735847B (zh) * 2021-09-10 2022-06-07 四川大学 一种盐酸小檗碱的合成制备方法

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Also Published As

Publication number Publication date
EP2727915A1 (en) 2014-05-07
CA2698808A1 (en) 2009-03-19
US20090143432A1 (en) 2009-06-04
US9315483B2 (en) 2016-04-19
JP5647519B2 (ja) 2014-12-24
WO2009035652A1 (en) 2009-03-19
US8822498B2 (en) 2014-09-02
EP2200997A1 (en) 2010-06-30
EP2200997B9 (en) 2016-01-13
MX2010002692A (es) 2010-06-01
CN101855218A (zh) 2010-10-06
AU2008299921A1 (en) 2009-03-19
JP2010539166A (ja) 2010-12-16
EP2727915B1 (en) 2016-04-13
US20140336387A1 (en) 2014-11-13
AU2008299921A8 (en) 2010-04-08
EP2200997B1 (en) 2013-11-06

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