MX2010002692A - Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. - Google Patents
Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos.Info
- Publication number
- MX2010002692A MX2010002692A MX2010002692A MX2010002692A MX2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A
- Authority
- MX
- Mexico
- Prior art keywords
- dioxoles
- benzo
- synthesis
- catechols
- deuterated
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 title 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical class C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99356507P | 2007-09-13 | 2007-09-13 | |
| PCT/US2008/010643 WO2009035652A1 (en) | 2007-09-13 | 2008-09-12 | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002692A true MX2010002692A (es) | 2010-06-01 |
Family
ID=40116877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002692A MX2010002692A (es) | 2007-09-13 | 2008-09-12 | Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8822498B2 (enExample) |
| EP (2) | EP2727915B1 (enExample) |
| JP (1) | JP5647519B2 (enExample) |
| CN (1) | CN101855218A (enExample) |
| AU (1) | AU2008299921B2 (enExample) |
| CA (1) | CA2698808A1 (enExample) |
| MX (1) | MX2010002692A (enExample) |
| WO (1) | WO2009035652A1 (enExample) |
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| KR101380190B1 (ko) * | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| CA2629514A1 (en) * | 2005-11-14 | 2007-05-24 | Auspex Pharmaceuticals, Inc. | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| ES2758028T3 (es) * | 2011-05-18 | 2020-05-04 | Vertex Pharmaceuticals Europe Ltd | Derivados deuterados de ivacaftor |
| US20120302526A1 (en) * | 2011-05-27 | 2012-11-29 | Regents Of The University Of Colorado, A Body Corporate | Methods for treating post-traumatic stress disorder |
| CN102924426B (zh) * | 2012-11-14 | 2014-07-02 | 广西师范大学 | 胡椒乙胺缩5-氯水杨醛及其合成方法和应用 |
| CN102942554B (zh) * | 2012-11-14 | 2014-05-28 | 广西师范大学 | 胡椒乙胺缩水杨醛及其合成方法和应用 |
| CN106459059B (zh) | 2014-05-13 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 氘化杂环化合物和其作为成像剂的用途 |
| CN104059030B (zh) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| CN103980271B (zh) * | 2014-05-30 | 2015-12-02 | 天津长森药业有限公司 | 黄藤素及其类似物的制备方法 |
| AU2015296098B2 (en) * | 2014-07-29 | 2019-06-27 | Shenzhen Hightide Biopharmaceutical, Ltd. | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| WO2016109795A1 (en) | 2014-12-31 | 2016-07-07 | Concert Pharmaceuticals, Inc. | Deuterated funapide and difluorofunapide |
| AU2016243171B2 (en) | 2015-03-31 | 2020-10-08 | Concert Pharmaceuticals, Inc. | Deuterated VX-661 |
| HK1258473A1 (zh) | 2015-09-25 | 2019-11-15 | Vertex Pharmaceuticals (Europe) Limited | 氘代cftr增效剂 |
| WO2017143874A1 (zh) * | 2016-02-25 | 2017-08-31 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的恶二唑类化合物及包含该化合物的组合物及其用途 |
| KR101970326B1 (ko) * | 2016-08-05 | 2019-04-18 | 고려대학교 산학협력단 | 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| IL305169B2 (en) | 2017-12-01 | 2025-07-01 | Vertex Pharma | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| CN113735847B (zh) * | 2021-09-10 | 2022-06-07 | 四川大学 | 一种盐酸小檗碱的合成制备方法 |
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| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| WO2011011420A2 (en) * | 2009-07-21 | 2011-01-27 | Auspex Pharmaceuticals, Inc. | 3, 4-methylenedioxyphenyl inhibitors of gaba aminotransferase and/or gaba reuptake transporter inhibitor |
-
2008
- 2008-09-12 JP JP2010524866A patent/JP5647519B2/ja not_active Expired - Fee Related
- 2008-09-12 EP EP13185607.2A patent/EP2727915B1/en not_active Not-in-force
- 2008-09-12 EP EP08830527.1A patent/EP2200997B9/en not_active Not-in-force
- 2008-09-12 CN CN200880110558A patent/CN101855218A/zh active Pending
- 2008-09-12 WO PCT/US2008/010643 patent/WO2009035652A1/en not_active Ceased
- 2008-09-12 MX MX2010002692A patent/MX2010002692A/es not_active Application Discontinuation
- 2008-09-12 AU AU2008299921A patent/AU2008299921B2/en not_active Ceased
- 2008-09-12 US US12/283,621 patent/US8822498B2/en not_active Expired - Fee Related
- 2008-09-12 CA CA2698808A patent/CA2698808A1/en not_active Abandoned
-
2014
- 2014-07-24 US US14/340,143 patent/US9315483B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2727915B1 (en) | 2016-04-13 |
| US20090143432A1 (en) | 2009-06-04 |
| CA2698808A1 (en) | 2009-03-19 |
| JP2010539166A (ja) | 2010-12-16 |
| EP2200997B1 (en) | 2013-11-06 |
| US8822498B2 (en) | 2014-09-02 |
| EP2200997A1 (en) | 2010-06-30 |
| EP2727915A1 (en) | 2014-05-07 |
| US20140336387A1 (en) | 2014-11-13 |
| AU2008299921A1 (en) | 2009-03-19 |
| CN101855218A (zh) | 2010-10-06 |
| JP5647519B2 (ja) | 2014-12-24 |
| EP2200997B9 (en) | 2016-01-13 |
| AU2008299921B2 (en) | 2012-03-01 |
| AU2008299921A8 (en) | 2010-04-08 |
| US9315483B2 (en) | 2016-04-19 |
| WO2009035652A1 (en) | 2009-03-19 |
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| FA | Abandonment or withdrawal |