MX2010002692A - Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. - Google Patents
Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos.Info
- Publication number
- MX2010002692A MX2010002692A MX2010002692A MX2010002692A MX2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A MX 2010002692 A MX2010002692 A MX 2010002692A
- Authority
- MX
- Mexico
- Prior art keywords
- dioxoles
- benzo
- synthesis
- catechols
- deuterated
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 title 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical class C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99356507P | 2007-09-13 | 2007-09-13 | |
| PCT/US2008/010643 WO2009035652A1 (en) | 2007-09-13 | 2008-09-12 | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002692A true MX2010002692A (es) | 2010-06-01 |
Family
ID=40116877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002692A MX2010002692A (es) | 2007-09-13 | 2008-09-12 | Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8822498B2 (enExample) |
| EP (2) | EP2727915B1 (enExample) |
| JP (1) | JP5647519B2 (enExample) |
| CN (1) | CN101855218A (enExample) |
| AU (1) | AU2008299921B2 (enExample) |
| CA (1) | CA2698808A1 (enExample) |
| MX (1) | MX2010002692A (enExample) |
| WO (1) | WO2009035652A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101380190B1 (ko) * | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| US20070112031A1 (en) * | 2005-11-14 | 2007-05-17 | Gant Thomas G | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| MX2010002692A (es) | 2007-09-13 | 2010-06-01 | Concert Pharmaceuticals Inc | Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. |
| JP6063455B2 (ja) * | 2011-05-18 | 2017-01-18 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたイバカフトルの誘導体 |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| US20120302526A1 (en) * | 2011-05-27 | 2012-11-29 | Regents Of The University Of Colorado, A Body Corporate | Methods for treating post-traumatic stress disorder |
| CN102942554B (zh) * | 2012-11-14 | 2014-05-28 | 广西师范大学 | 胡椒乙胺缩水杨醛及其合成方法和应用 |
| CN102924426B (zh) * | 2012-11-14 | 2014-07-02 | 广西师范大学 | 胡椒乙胺缩5-氯水杨醛及其合成方法和应用 |
| HUE053939T2 (hu) | 2014-05-13 | 2021-08-30 | Hoffmann La Roche | Deuterált heterociklikus vegyületek és képalkotó kontrasztanyagként való használatuk |
| CN103980271B (zh) * | 2014-05-30 | 2015-12-02 | 天津长森药业有限公司 | 黄藤素及其类似物的制备方法 |
| CN104059030B (zh) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| IL282156B (en) * | 2014-07-29 | 2022-07-01 | Shenzhen Hightide Biopharmaceutical Ltd | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| WO2016109795A1 (en) | 2014-12-31 | 2016-07-07 | Concert Pharmaceuticals, Inc. | Deuterated funapide and difluorofunapide |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| HK1258473A1 (zh) | 2015-09-25 | 2019-11-15 | Vertex Pharmaceuticals (Europe) Limited | 氘代cftr增效剂 |
| CN108602786B (zh) | 2016-02-25 | 2019-04-23 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的噁二唑类化合物及包含该化合物的组合物及其用途 |
| KR101970326B1 (ko) * | 2016-08-05 | 2019-04-18 | 고려대학교 산학협력단 | 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| CA3082444A1 (en) | 2017-12-01 | 2019-06-06 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| CN113735847B (zh) * | 2021-09-10 | 2022-06-07 | 四川大学 | 一种盐酸小檗碱的合成制备方法 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US4585777A (en) * | 1984-02-07 | 1986-04-29 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT |
| WO1989001342A2 (en) * | 1987-08-07 | 1989-02-23 | Mallinckrodt, Inc. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5708035A (en) | 1991-02-04 | 1998-01-13 | Sepracor Inc. | Methods of use and compositions of R(-) fluoxetine |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US5597826A (en) * | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| GB9514842D0 (en) | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
| US5958429A (en) | 1996-08-16 | 1999-09-28 | Eli Lilly And Company | Potentiation of serotonin response |
| UA56185C2 (uk) | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| EP0977573A1 (en) | 1997-04-24 | 2000-02-09 | MERCK SHARP & DOHME LTD. | Use of an nk-1 receptor antagonist and an ssri for treating obesity |
| IT1291320B1 (it) | 1997-05-08 | 1999-01-07 | Borregaard Italia Spa | Procedimento per la preparazione di composti aromatici contenenti un sistema eterociclico |
| SK283394B6 (sk) * | 1997-06-10 | 2003-07-01 | Synthon B. V. | Zlúčeniny 4-fenylpiperidínu a jej farmaceuticky prijateľné soli, spôsob ich prípravy, liečivo s ich obsahom a ich použitie |
| JP2001518520A (ja) | 1997-10-03 | 2001-10-16 | キャリー メディカル コーポレイション | ニコチンレセプターアンタゴニストおよび抗抑うつ薬または抗不安薬を含有するニコチン嗜癖を治療する組成物 |
| US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| PT1064256E (pt) | 1998-03-17 | 2004-10-29 | Pfizer Prod Inc | Biciclo[2.2.1] heptanos e compostos relacionados |
| US20030187269A1 (en) * | 1998-04-17 | 2003-10-02 | Curzons Alan David | Novel process |
| GB9817195D0 (en) * | 1998-08-07 | 1998-10-07 | Smithkline Beecham Plc | Novel process |
| US6376531B1 (en) * | 1998-11-13 | 2002-04-23 | Rupert Charles Bell | Method of treatment using deuterium compounds |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| CA2360683A1 (en) | 1999-01-28 | 2000-08-03 | Joseph P. Yevich | Antidepressant heterocyclic compounds |
| US20030055070A1 (en) | 1999-07-01 | 2003-03-20 | Wilma Harrison | Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of selective serotonin reuptake inhibitor (SSR) induced sexual dysfunction |
| GB9916187D0 (en) | 1999-07-09 | 1999-09-08 | Smithkline Beecham Plc | Novel process |
| IL137937A0 (en) | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| US20010036943A1 (en) | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| US20040229911A1 (en) | 2000-05-17 | 2004-11-18 | Pfizer Inc | New pharmaceutical combinations for NOS inhibitors |
| DOP2001000154A (es) | 2000-05-25 | 2002-05-15 | Pfizer Prod Inc | Combinación de secretagogos de hormona del crecimiento y antidepresivos |
| EP1181933A3 (en) | 2000-06-29 | 2002-04-10 | Pfizer Products Inc. | Use of growth hormone secretagogues for stimulating or increasing appetite |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| US20020077323A1 (en) | 2000-07-12 | 2002-06-20 | Mclean Stafford | Use of delta opioid receptor ligands and serotonin reuptake inhibitors in the treatment of chemical dependencies |
| GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| WO2002085871A2 (en) | 2001-04-04 | 2002-10-31 | Wyeth | Serotonergic agents with long-acting in vivo effects |
| US6656951B2 (en) | 2001-04-24 | 2003-12-02 | Wyeth | 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists |
| WO2002088145A1 (en) | 2001-04-26 | 2002-11-07 | Wyeth | AZABICYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZACYCLOPENTA[a]NAPHTHALENE AS 5-HT1A ANTAGONISTS |
| US6861427B2 (en) | 2001-04-26 | 2005-03-01 | Wyeth | Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists |
| US6821981B2 (en) | 2001-04-26 | 2004-11-23 | Wyeth | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists |
| US6815448B2 (en) | 2001-05-07 | 2004-11-09 | Wyeth | Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists |
| JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
| CA2459304A1 (en) | 2001-09-13 | 2003-03-20 | Schering Corporation | Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic |
| US7019010B2 (en) | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
| CA2468159A1 (en) | 2001-11-27 | 2003-06-05 | Merck & Co., Inc. | 4-aminoquinoline compounds |
| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| US20050014848A1 (en) | 2002-01-23 | 2005-01-20 | Pfizer Inc. | Combination of serotonin reuptake inhibitors and norephinephrine reuptake inhibitors |
| AU2003209388A1 (en) | 2002-01-29 | 2003-09-02 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| JP4458853B2 (ja) | 2002-03-13 | 2010-04-28 | シェーリング コーポレイション | Ｎｋ１アンタゴニスト |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| DE10261807A1 (de) * | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
| US20040224943A1 (en) | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
| ATE409480T1 (de) | 2003-06-27 | 2008-10-15 | Pfizer Prod Inc | Pyrazoloä3,4-büpyridin-6-one als gsk-3 inhibitoren |
| US20050070577A1 (en) | 2003-07-03 | 2005-03-31 | Pfizer Inc. | Compositions containing a serotonin selective reuptake inhibitor and a 5-HT2A receptor antagonist |
| WO2005018541A2 (en) | 2003-07-11 | 2005-03-03 | Pharmacia Corporation | Cox-2 inhibitor and serotonin modulator for treating cns damage |
| WO2005007628A1 (en) | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| BRPI0413679A (pt) | 2003-08-22 | 2006-10-24 | Pharmacia Corp | formulações de um inibidor seletivo da ciclooxigenase-2 e de um agente de modulação da serotonina para o tratamento da neoplasia |
| WO2005037199A2 (en) | 2003-10-10 | 2005-04-28 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
| WO2005063761A1 (en) | 2003-12-19 | 2005-07-14 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
| WO2005107716A1 (en) | 2004-03-25 | 2005-11-17 | Cadila Healthcare Limited | Controlled release paroxetine-containing tablets based on a core and a coating |
| FR2869033B1 (fr) | 2004-04-20 | 2006-06-02 | Rhodia Chimie Sa | Procede de preparation de methylenedioxybenzene |
| US20050266082A1 (en) | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
| KR100920856B1 (ko) | 2004-11-30 | 2009-10-09 | (주)아모레퍼시픽 | 선택적 세로토닌 재흡수 억제제의 연장방출 제제 및 그제조방법 |
| US20080213381A1 (en) | 2005-03-14 | 2008-09-04 | Pharmaceutical Industries Limited | Oral Drug Delivery System |
| KR20070009934A (ko) | 2005-07-16 | 2007-01-19 | 주식회사 씨티씨바이오 | 염산 파록세틴 서방정 및 이의 제조방법 |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US7863274B2 (en) * | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
| AU2006275702A1 (en) * | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| KR101380190B1 (ko) * | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| WO2007015270A2 (en) | 2005-08-02 | 2007-02-08 | Lupin Limited | Novel controlled release compositions of selective serotonin reuptake inhibitors |
| US20070112031A1 (en) * | 2005-11-14 | 2007-05-17 | Gant Thomas G | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| EP1934201A1 (en) | 2005-10-06 | 2008-06-25 | Auspex Pharmaceuticals Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| US20090291958A1 (en) | 2006-06-08 | 2009-11-26 | Auspex Pharmaceuticals, Inc. | Substituted PDE5 inhibitors |
| WO2008016677A2 (en) * | 2006-08-02 | 2008-02-07 | Auspex Pharmaceuticals, Inc. | Preparation and utility of deuterated amphetamines |
| US20080103122A1 (en) * | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| MX2010002692A (es) | 2007-09-13 | 2010-06-01 | Concert Pharmaceuticals Inc | Sintesis de catecoles deuterados y derivados de benzo[d][1,3]dioxoles de los mismos. |
| US20110257260A1 (en) * | 2009-07-21 | 2011-10-20 | Auspex Pharmaceuticals, Inc. | 3,4-methylenedioxyphenyl inhibitors of gaba aminotransferase and/or gaba reuptake transporter inhibitor |
-
2008
- 2008-09-12 MX MX2010002692A patent/MX2010002692A/es not_active Application Discontinuation
- 2008-09-12 EP EP13185607.2A patent/EP2727915B1/en not_active Not-in-force
- 2008-09-12 CA CA2698808A patent/CA2698808A1/en not_active Abandoned
- 2008-09-12 WO PCT/US2008/010643 patent/WO2009035652A1/en not_active Ceased
- 2008-09-12 JP JP2010524866A patent/JP5647519B2/ja not_active Expired - Fee Related
- 2008-09-12 AU AU2008299921A patent/AU2008299921B2/en not_active Ceased
- 2008-09-12 EP EP08830527.1A patent/EP2200997B9/en not_active Not-in-force
- 2008-09-12 CN CN200880110558A patent/CN101855218A/zh active Pending
- 2008-09-12 US US12/283,621 patent/US8822498B2/en not_active Expired - Fee Related
-
2014
- 2014-07-24 US US14/340,143 patent/US9315483B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9315483B2 (en) | 2016-04-19 |
| AU2008299921A1 (en) | 2009-03-19 |
| EP2727915A1 (en) | 2014-05-07 |
| EP2727915B1 (en) | 2016-04-13 |
| US20090143432A1 (en) | 2009-06-04 |
| CN101855218A (zh) | 2010-10-06 |
| JP2010539166A (ja) | 2010-12-16 |
| WO2009035652A1 (en) | 2009-03-19 |
| AU2008299921B2 (en) | 2012-03-01 |
| AU2008299921A8 (en) | 2010-04-08 |
| CA2698808A1 (en) | 2009-03-19 |
| US20140336387A1 (en) | 2014-11-13 |
| US8822498B2 (en) | 2014-09-02 |
| EP2200997B1 (en) | 2013-11-06 |
| EP2200997B9 (en) | 2016-01-13 |
| JP5647519B2 (ja) | 2014-12-24 |
| EP2200997A1 (en) | 2010-06-30 |
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| FA | Abandonment or withdrawal |