JP5640207B2 - 水性眼用処方物 - Google Patents
水性眼用処方物 Download PDFInfo
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- JP5640207B2 JP5640207B2 JP2010528310A JP2010528310A JP5640207B2 JP 5640207 B2 JP5640207 B2 JP 5640207B2 JP 2010528310 A JP2010528310 A JP 2010528310A JP 2010528310 A JP2010528310 A JP 2010528310A JP 5640207 B2 JP5640207 B2 JP 5640207B2
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- Prior art keywords
- cyclosporine
- formulation
- eye
- ophthalmic formulation
- formulation according
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| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| RU2014102492A (ru) * | 2011-06-29 | 2015-08-10 | Аллерган, Инк. | Композиции макрогол 15 гидроксистеарата |
| US20130029919A1 (en) * | 2011-07-26 | 2013-01-31 | Allergan, Inc. | Two part formulation system for opthalmic delivery |
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| EP2825206A1 (en) | 2012-03-16 | 2015-01-21 | The Johns Hopkins University | Controlled release formulations for the delivery of hif-1 inhibitors |
| FR2988297B1 (fr) * | 2012-03-22 | 2014-03-28 | Thea Lab | Solution ophtalmique aqueuse a base de ciclosporine a sans conservateur |
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| US9889208B2 (en) | 2012-05-04 | 2018-02-13 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| ES2759781T3 (es) | 2012-07-27 | 2020-05-12 | Glia Llc | Composiciones y tratamiento para enfermedades y trastornos oculares |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| KR101363776B1 (ko) * | 2012-12-21 | 2014-02-17 | 이상필 | 사이클로스포린을 포함하는 투명 점안액 조성물 |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
| US20150352176A1 (en) * | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016018993A1 (en) | 2014-07-29 | 2016-02-04 | Therapeuticsmd, Inc. | Transdermal cream |
| JP6671141B2 (ja) * | 2014-10-21 | 2020-03-25 | 大日本住友製薬株式会社 | 懸濁液剤 |
| US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| KR20240126072A (ko) | 2015-01-27 | 2024-08-20 | 더 존스 홉킨스 유니버시티 | 점막표면에서 활성제의 향상된 수송을 위한 저장성 하이드로겔 제제 |
| US11052094B2 (en) | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| WO2016205071A1 (en) * | 2015-06-18 | 2016-12-22 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR101635915B1 (ko) * | 2016-02-15 | 2016-07-04 | 삼천당제약주식회사 | 사이클로스포린과 히알루론산 또는 이의 염을 포함하는 수용액 형태의 안과용 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10711070B1 (en) * | 2017-03-22 | 2020-07-14 | The United States Of America As Represented By The Secretary Of The Army | Method for preparing spherical celluloid beads |
| RU2745603C1 (ru) | 2017-05-11 | 2021-03-29 | Невакар Инк. | Фармацевтические композиции атропина |
| RU2668713C1 (ru) * | 2018-03-16 | 2018-10-02 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский институт глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации | Способ лечения центральных язв роговицы бактериальной и герпетической этиологии |
| PL3681500T3 (pl) | 2018-04-24 | 2022-08-01 | Allergan, Inc. | Zastosowanie chlorowodorku pilokarpiny w leczeniu starczowzroczności |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| JP2020152674A (ja) * | 2019-03-20 | 2020-09-24 | 株式会社リコー | 難水溶性化合物の可溶化物の製造方法 |
| WO2020210805A1 (en) | 2019-04-11 | 2020-10-15 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| US12180206B2 (en) | 2021-11-17 | 2024-12-31 | Lenz Therapeutics Operations, Inc. | Aceclidine derivatives, compositions thereof and methods of use thereof |
| US12414942B1 (en) | 2024-03-15 | 2025-09-16 | Lenz Therapeutics Operations, Inc. | Compositions, methods, and systems for treating presbyopia |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155377C (no) * | 1980-03-21 | 1987-03-25 | Wellcome Found | Fremgangsmaate til fremstilling av et stabilisert isotonisk vaeskeformig preparat. |
| US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| JPS59101478A (ja) * | 1982-11-29 | 1984-06-12 | Sunstar Inc | リグスチライドを安定に配合した水系組成物 |
| JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US6465016B2 (en) * | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| AR002194A1 (es) * | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| JP2000143542A (ja) * | 1998-11-10 | 2000-05-23 | Wakamoto Pharmaceut Co Ltd | 難溶性免疫抑制剤含有ｏ／ｗエマルジョン製剤 |
| WO2001030337A2 (en) * | 1999-10-22 | 2001-05-03 | Orbon Corporation | Ophthalmic formulation of dopamine antagonists |
| TR200302105T4 (tr) * | 2000-04-07 | 2004-02-23 | Laboratoire Medidom S. A. | Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları. |
| JP2005154334A (ja) * | 2003-11-25 | 2005-06-16 | Toa Yakuhin Kk | アズレンスルホン酸塩水溶液剤 |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| US20060148686A1 (en) * | 2004-12-30 | 2006-07-06 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy |
| US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| US20070087962A1 (en) * | 2005-10-17 | 2007-04-19 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| DE102006051512A1 (de) * | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
| US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
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2008
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- 2008-10-08 JP JP2010528310A patent/JP5640207B2/ja not_active Expired - Fee Related
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- 2008-10-08 EA EA201000441A patent/EA019867B1/ru not_active IP Right Cessation
- 2008-10-08 US US12/681,982 patent/US20120028910A1/en not_active Abandoned
- 2008-10-08 EP EP08802821A patent/EP2195033A1/en not_active Withdrawn
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| JP2010540671A (ja) | 2010-12-24 |
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| WO2009046967A1 (en) | 2009-04-16 |
| NZ584275A (en) | 2012-06-29 |
| BRPI0819081A8 (pt) | 2016-08-30 |
| HK1147937A1 (en) | 2011-08-26 |
| CA2702082A1 (en) | 2009-04-16 |
| EA201000441A1 (ru) | 2010-10-29 |
| AU2008309923A1 (en) | 2009-04-16 |
| AU2008309923B2 (en) | 2014-04-03 |
| BRPI0819081A2 (pt) | 2015-04-22 |
| EA019867B1 (ru) | 2014-06-30 |
| CN101820917A (zh) | 2010-09-01 |
| MX2010003774A (es) | 2010-04-27 |
| ZA201003195B (en) | 2011-02-23 |
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