JP5622568B2 - ベンズアミドｍＧｌｕＲ５の正のアロステリック調節因子ならびにその作製および使用方法 - Google Patents

ベンズアミドｍＧｌｕＲ５の正のアロステリック調節因子ならびにその作製および使用方法 Download PDF

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JP5622568B2
JP5622568B2 JP2010511277A JP2010511277A JP5622568B2 JP 5622568 B2 JP5622568 B2 JP 5622568B2 JP 2010511277 A JP2010511277 A JP 2010511277A JP 2010511277 A JP2010511277 A JP 2010511277A JP 5622568 B2 JP5622568 B2 JP 5622568B2
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optionally substituted
phenyl
alkyl
hydrogen
compound
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JP2010529135A5 (enExample
JP2010529135A (ja
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ピー． ジェフリー コン，
ピー． ジェフリー コン，
ダブリュー． リンズレイ，クレイグ
クレイグ ダブリュー． リンズレイ，
デイビッド ウェーバー，チャールズ
チャールズ デイビッド ウェーバー，
エル． ロドリゲス，アリス
アリス エル． ロドリゲス，
コリーンエム． ニスウェンダー，
コリーン エム． ニスウェンダー，
キャリー ケー． ジョニス，
キャリー ケー． ジョニス，
リチャード ウィリアムス，
リチャード ウィリアムス，
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バンダービルト ユニバーシティ
バンダービルト ユニバーシティ
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    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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