CN101795689B - 苯甲酰胺mGluR5正性变构调节剂和制备与使用所述调节剂的方法 - Google Patents
苯甲酰胺mGluR5正性变构调节剂和制备与使用所述调节剂的方法 Download PDFInfo
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- CN101795689B CN101795689B CN200880100770.6A CN200880100770A CN101795689B CN 101795689 B CN101795689 B CN 101795689B CN 200880100770 A CN200880100770 A CN 200880100770A CN 101795689 B CN101795689 B CN 101795689B
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- phenylethynyl
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- 0 *c1cccc(C#Cc(cc2)ccc2C(N2CCOCC2)=O)c1 Chemical compound *c1cccc(C#Cc(cc2)ccc2C(N2CCOCC2)=O)c1 0.000 description 31
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- NQDGPMBBODUESO-UHFFFAOYSA-N CC(CC1)(CCN1C(c(cc1)ccc1C#Cc(cc1)cc(F)c1F)=O)O Chemical compound CC(CC1)(CCN1C(c(cc1)ccc1C#Cc(cc1)cc(F)c1F)=O)O NQDGPMBBODUESO-UHFFFAOYSA-N 0.000 description 1
- YIWHCMHLCHGWAX-UHFFFAOYSA-N CC(CC1)(CCN1C(c1ccc(C)cc1)=O)O Chemical compound CC(CC1)(CCN1C(c1ccc(C)cc1)=O)O YIWHCMHLCHGWAX-UHFFFAOYSA-N 0.000 description 1
- FRVAFFCBUNGKIU-UHFFFAOYSA-N CC(CCCC1)N1C(c(cc1)ccc1C(Nc(cc1)ccc1F)=O)=O Chemical compound CC(CCCC1)N1C(c(cc1)ccc1C(Nc(cc1)ccc1F)=O)=O FRVAFFCBUNGKIU-UHFFFAOYSA-N 0.000 description 1
- ARCSBFATIFHVTF-UHFFFAOYSA-N CCc1n[o]cn1 Chemical compound CCc1n[o]cn1 ARCSBFATIFHVTF-UHFFFAOYSA-N 0.000 description 1
- SBMKEDOUIMJCKH-UHFFFAOYSA-N Cc(cc(cc1)C#Cc(cc2)ccc2C(N(CC2)CCC2O)=O)c1F Chemical compound Cc(cc(cc1)C#Cc(cc2)ccc2C(N(CC2)CCC2O)=O)c1F SBMKEDOUIMJCKH-UHFFFAOYSA-N 0.000 description 1
- BTQZKHUEUDPRST-UHFFFAOYSA-N Cc1cccc(F)c1 Chemical compound Cc1cccc(F)c1 BTQZKHUEUDPRST-UHFFFAOYSA-N 0.000 description 1
- JLAYIIXMXGNSHD-UHFFFAOYSA-N O=C(C(C=C1)=CCC1C#Cc1ccccc1)NCCc(cccc1)c1Cl Chemical compound O=C(C(C=C1)=CCC1C#Cc1ccccc1)NCCc(cccc1)c1Cl JLAYIIXMXGNSHD-UHFFFAOYSA-N 0.000 description 1
- BUSCSHOQPVCMCD-UHFFFAOYSA-N O=C(C1C=CC(C#Cc2ccccc2F)=CC1)N1CCOCC1 Chemical compound O=C(C1C=CC(C#Cc2ccccc2F)=CC1)N1CCOCC1 BUSCSHOQPVCMCD-UHFFFAOYSA-N 0.000 description 1
- ZBFKKMRAPQHJTF-UHFFFAOYSA-N O=C(c(cc1)ccc1C#Cc1ccccc1)NCCC(CC1)=CC=C1Cl Chemical compound O=C(c(cc1)ccc1C#Cc1ccccc1)NCCC(CC1)=CC=C1Cl ZBFKKMRAPQHJTF-UHFFFAOYSA-N 0.000 description 1
- OXQAERGYFBAAKJ-UHFFFAOYSA-N OC(C1)CN1C(c(cc1)ccc1C#Cc(cc1)ccc1F)=O Chemical compound OC(C1)CN1C(c(cc1)ccc1C#Cc(cc1)ccc1F)=O OXQAERGYFBAAKJ-UHFFFAOYSA-N 0.000 description 1
- YOKAJIZBNOALKT-UHFFFAOYSA-N OC(CC1)CCN1C(c(cc1)ccc1C#Cc(c(F)c1)ccc1F)=O Chemical compound OC(CC1)CCN1C(c(cc1)ccc1C#Cc(c(F)c1)ccc1F)=O YOKAJIZBNOALKT-UHFFFAOYSA-N 0.000 description 1
- AEAFUHAMURSSKJ-UHFFFAOYSA-N OC(CC1)CCN1C(c(cc1)ccc1C#Cc1cc(F)cc(F)c1)=O Chemical compound OC(CC1)CCN1C(c(cc1)ccc1C#Cc1cc(F)cc(F)c1)=O AEAFUHAMURSSKJ-UHFFFAOYSA-N 0.000 description 1
- JIPIRDBWUHJQEG-UHFFFAOYSA-N OC(c(cc1)ccc1C#Cc(cc1)cc(F)c1F)=O Chemical compound OC(c(cc1)ccc1C#Cc(cc1)cc(F)c1F)=O JIPIRDBWUHJQEG-UHFFFAOYSA-N 0.000 description 1
- FGTYPPVXKJSFPR-UHFFFAOYSA-N OC1C=CNCC1 Chemical compound OC1C=CNCC1 FGTYPPVXKJSFPR-UHFFFAOYSA-N 0.000 description 1
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- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US94168607P | 2007-06-03 | 2007-06-03 | |
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| US98504107P | 2007-11-02 | 2007-11-02 | |
| US60/985,041 | 2007-11-02 | ||
| PCT/US2008/065647 WO2008151184A1 (en) | 2007-06-03 | 2008-06-03 | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
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| CN101795689A CN101795689A (zh) | 2010-08-04 |
| CN101795689B true CN101795689B (zh) | 2014-11-19 |
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| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
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| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
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| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
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| SG185285A1 (en) | 2012-11-29 |
| EP2162136A1 (en) | 2010-03-17 |
| AU2008259776A2 (en) | 2010-01-28 |
| BRPI0812363A2 (pt) | 2015-02-03 |
| AU2008259776A1 (en) | 2008-12-11 |
| KR20100033981A (ko) | 2010-03-31 |
| EP2162136A4 (en) | 2012-02-15 |
| NZ581817A (en) | 2012-05-25 |
| CN101795689A (zh) | 2010-08-04 |
| HK1147068A1 (en) | 2011-07-29 |
| WO2008151184A1 (en) | 2008-12-11 |
| MX2009013169A (es) | 2010-04-30 |
| IL202508A0 (en) | 2010-06-30 |
| CA2689282A1 (en) | 2008-12-11 |
| EA200971143A1 (ru) | 2010-06-30 |
| JP5622568B2 (ja) | 2014-11-12 |
| JP2010529135A (ja) | 2010-08-26 |
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