JP5615274B2 - Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法 - Google Patents

Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法 Download PDF

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Publication number
JP5615274B2
JP5615274B2 JP2011516857A JP2011516857A JP5615274B2 JP 5615274 B2 JP5615274 B2 JP 5615274B2 JP 2011516857 A JP2011516857 A JP 2011516857A JP 2011516857 A JP2011516857 A JP 2011516857A JP 5615274 B2 JP5615274 B2 JP 5615274B2
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alkyl
compound
formula
acid
solvent
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JP2011516857A
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Japanese (ja)
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JP2011526924A (ja
JP2011526924A5 (https=
Inventor
エマヌエラ ガンチア，
エマヌエラ ガンチア，
ロバート， アンドリュー ヒールド，
ロバート， アンドリュー ヒールド，
フィリップ ジャクソン，
フィリップ ジャクソン，
スティーヴン プライス，
スティーヴン プライス，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2011516857A 2008-07-01 2009-07-01 Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法 Expired - Fee Related JP5615274B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7743208P 2008-07-01 2008-07-01
US61/077,432 2008-07-01
PCT/US2009/049449 WO2010003022A1 (en) 2008-07-01 2009-07-01 Isoindolone derivatives as mek kinase inhibitors and methods of use

Publications (3)

Publication Number Publication Date
JP2011526924A JP2011526924A (ja) 2011-10-20
JP2011526924A5 JP2011526924A5 (https=) 2012-08-16
JP5615274B2 true JP5615274B2 (ja) 2014-10-29

Family

ID=41128054

Family Applications (1)

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JP2011516857A Expired - Fee Related JP5615274B2 (ja) 2008-07-01 2009-07-01 Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法

Country Status (16)

Country Link
US (1) US8492427B2 (https=)
EP (1) EP2307364B1 (https=)
JP (1) JP5615274B2 (https=)
KR (1) KR20110028376A (https=)
CN (1) CN102137843A (https=)
AU (1) AU2009266953A1 (https=)
BR (1) BRPI0910200A2 (https=)
CA (1) CA2727252A1 (https=)
CL (1) CL2010001637A1 (https=)
ES (1) ES2426096T3 (https=)
IL (1) IL209892A0 (https=)
MX (1) MX2010014565A (https=)
PE (1) PE20110424A1 (https=)
RU (1) RU2495028C2 (https=)
WO (1) WO2010003022A1 (https=)
ZA (1) ZA201008962B (https=)

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KR20180134347A (ko) 2016-04-15 2018-12-18 제넨테크, 인크. 암의 진단 및 치료 방법
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Also Published As

Publication number Publication date
AU2009266953A1 (en) 2010-01-07
RU2495028C2 (ru) 2013-10-10
WO2010003022A8 (en) 2010-09-30
CA2727252A1 (en) 2010-01-07
ZA201008962B (en) 2012-03-28
KR20110028376A (ko) 2011-03-17
JP2011526924A (ja) 2011-10-20
EP2307364A1 (en) 2011-04-13
MX2010014565A (es) 2011-03-04
EP2307364B1 (en) 2013-06-19
US8492427B2 (en) 2013-07-23
RU2011103434A (ru) 2012-08-10
CL2010001637A1 (es) 2011-07-15
PE20110424A1 (es) 2011-07-22
IL209892A0 (en) 2011-02-28
ES2426096T3 (es) 2013-10-21
BRPI0910200A2 (pt) 2015-09-29
US20110124622A1 (en) 2011-05-26
AU2009266953A2 (en) 2011-01-27
CN102137843A (zh) 2011-07-27
WO2010003022A1 (en) 2010-01-07

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