JP5613372B2 - 多孔性金属インプラントの形成方法 - Google Patents
多孔性金属インプラントの形成方法 Download PDFInfo
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- JP5613372B2 JP5613372B2 JP2008555311A JP2008555311A JP5613372B2 JP 5613372 B2 JP5613372 B2 JP 5613372B2 JP 2008555311 A JP2008555311 A JP 2008555311A JP 2008555311 A JP2008555311 A JP 2008555311A JP 5613372 B2 JP5613372 B2 JP 5613372B2
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- JP
- Japan
- Prior art keywords
- mixture
- metal
- implant
- spacing agent
- metal powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61L2300/64—Animal cells
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Description
本出願は、表題「Method and Apparatus for Use of Porous Implants」の米国特許出願第11/357868号明細書(代理人整理番号5490−000410/CPB)に関連しており、その開示は参照によって組込まれている。「Method and Apparatus for
Use of Porous Implants」は本願と同時出願され、インディアナ州ワルシャワのBiomet
Manufacturing社の同一出願人による。
本発明は多孔性金属インプラントおよび製造方法に関する。
多孔性金属インプラントは、囲繞骨組織および軟組織のインプラント内への内方成長を促進するのに使用される。金属の多孔性、完全性および連続性が充分である場合、多孔性インプラントは、インプラント場所へ所望の耐荷重強度を与える組織内方成長の足場として機能する。
本発明は、生体適合性金属粉末、離隔剤および非極性液体バインダの混合物を調製する工程を含む多孔性金属インプラントの調製方法であって、離隔剤が非極性液体バインダに実質的に不溶性である方法を提供する。混合物が成形され、非極性液体バインダおよび離隔剤が混合物から除去されて、金属インプラント内に複数の孔を形成する。
以下の記載は単に実際の例であり、本発明、その用途または使用を限定することを意図したものでは決してない。種々の実施形態は、人工ひざまたは人工股関節装置と使用するための多孔性金属インプラントと関連して記載されるが、本発明のインプラントおよび方法は、あらゆる適切な基質または形状であり、あらゆる適切な手順で使用することができ、例示されたものだけではないことが理解される。
Claims (10)
- 多孔性金属インプラントの調製方法であって、
1.a.チタン、チタン合金、コバルト、コバルト合金、クロム、クロム合金、タンタル、タンタル合金およびステンレス鋼から成る群から選択される生体適合性金属粉末と、
b.重炭酸アンモニウムを含む離隔剤と、
c.d−リモネンを含む非極性液体バインダとを有する混合物を調製する工程と、
2.混合物を成形する工程と、
3.離隔剤を昇華によって除去して金属インプラント内に複数の孔を形成する工程とを含むことを特徴とする方法。 - 生体適合性金属粉末がTi−6Al−4Vを含むことを特徴とする請求項1記載の方法。
- 離隔剤が熱循環によって除去されることを特徴とする請求項1または2に記載の方法。
- 請求項1〜3のいずれか1項に記載の方法であって、さらに、
a.混合物の少なくとも一部の周りに固定要素を配置する工程と、
b.混合物を固定要素内に置きながら混合物を型で成形する工程と、
c.離隔剤および非極性液体バインダを形成された形状から昇華させる工程と、
d.固定要素を除去する工程と、
e.形成された形状を焼結する工程とを含むことを特徴とする方法。 - 固定要素が、金属箔、ゴム、またはシリコーン樹脂を含む可撓性材料で製造されることを特徴とする請求項4記載の方法。
- 多孔性金属インプラントの調製方法であって、
a. i.生体適合性金属粉末と、
ii.重炭酸アンモニウムと、
iii.d−リモネンとを有する混合物を調製する工程と、
b.混合物を成形する工程と、
c.混合物を1つの加熱ユニット内で熱循環させて重炭酸アンモニウムおよびd−リモネンを除去し、かつ金属粉末を焼結して金属インプラント内に複数の孔を形成する工程とを含むことを特徴とする方法。 - 金属粉末が結合して金属インプラントを形成するまで加熱ユニット内で混合物を連続して維持する工程をさらに含むことを特徴とする請求項6記載の方法。
- 熱循環が少なくとも1回の焼結および少なくとも1回の焼入れを含むことを特徴とする請求項6または7に記載の方法。
- 生体適合性粉末が、チタン、チタン合金、コバルト、コバルト合金、クロム、クロム合金、タンタル、タンタル合金およびステンレス鋼から成る群から選択されることを特徴とする請求項6〜8のいずれか1項に記載の方法。
- 焼成によって金属基板をインプラントに取り付ける工程を、さらに含むことを特徴とする請求項6〜9のいずれか1項に記載の方法。
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US11/357,929 US7635447B2 (en) | 2006-02-17 | 2006-02-17 | Method and apparatus for forming porous metal implants |
PCT/US2007/003811 WO2007097949A2 (en) | 2006-02-17 | 2007-02-09 | Method and apparatus for forming porous metal implants |
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US20070196230A1 (en) | 2007-08-23 |
WO2007097949A2 (en) | 2007-08-30 |
EP1996248A4 (en) | 2012-02-29 |
EP1996248A2 (en) | 2008-12-03 |
US20100003155A1 (en) | 2010-01-07 |
CN101405039A (zh) | 2009-04-08 |
US7883661B2 (en) | 2011-02-08 |
JP5885778B2 (ja) | 2016-03-15 |
EP1996248B1 (en) | 2016-04-20 |
JP2009526614A (ja) | 2009-07-23 |
US20130118377A1 (en) | 2013-05-16 |
WO2007097949A3 (en) | 2007-11-29 |
AU2007217978A1 (en) | 2007-08-30 |
US8361380B2 (en) | 2013-01-29 |
AU2007217978B2 (en) | 2013-01-10 |
CN101405039B (zh) | 2013-10-16 |
US8814978B2 (en) | 2014-08-26 |
US20110123382A1 (en) | 2011-05-26 |
JP2014221945A (ja) | 2014-11-27 |
US7635447B2 (en) | 2009-12-22 |
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