JP5611846B2 - 置換ヘテロ環縮合ガンマ−カルボリン類固体 - Google Patents

置換ヘテロ環縮合ガンマ−カルボリン類固体 Download PDF

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Publication number
JP5611846B2
JP5611846B2 JP2010550697A JP2010550697A JP5611846B2 JP 5611846 B2 JP5611846 B2 JP 5611846B2 JP 2010550697 A JP2010550697 A JP 2010550697A JP 2010550697 A JP2010550697 A JP 2010550697A JP 5611846 B2 JP5611846 B2 JP 5611846B2
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salt
salt crystal
ray powder
powder diffraction
disorder
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JP2011513485A (ja
JP2011513485A5 (https=
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ローレンス・ピー・ウェノグル
ジョン・トメシュ
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
JP2010550697A 2008-03-12 2009-03-12 置換ヘテロ環縮合ガンマ−カルボリン類固体 Active JP5611846B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3606908P 2008-03-12 2008-03-12
US61/036,069 2008-03-12
PCT/US2009/001608 WO2009114181A2 (en) 2008-03-12 2009-03-12 Substituted heterocycle fused gamma-carbolines solid

Publications (3)

Publication Number Publication Date
JP2011513485A JP2011513485A (ja) 2011-04-28
JP2011513485A5 JP2011513485A5 (https=) 2014-05-22
JP5611846B2 true JP5611846B2 (ja) 2014-10-22

Family

ID=41065729

Family Applications (1)

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JP2010550697A Active JP5611846B2 (ja) 2008-03-12 2009-03-12 置換ヘテロ環縮合ガンマ−カルボリン類固体

Country Status (16)

Country Link
US (4) US8648077B2 (https=)
EP (1) EP2262505B1 (https=)
JP (1) JP5611846B2 (https=)
KR (2) KR20150140418A (https=)
CN (2) CN105237536A (https=)
AU (1) AU2009223701B2 (https=)
CA (1) CA2716730C (https=)
DK (1) DK2262505T3 (https=)
ES (1) ES2530090T3 (https=)
HR (1) HRP20141178T1 (https=)
IL (3) IL207772A0 (https=)
MX (2) MX2010010024A (https=)
PL (1) PL2262505T3 (https=)
PT (1) PT2262505E (https=)
SI (1) SI2262505T1 (https=)
WO (1) WO2009114181A2 (https=)

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US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
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Publication number Publication date
MX2010010024A (es) 2010-11-09
WO2009114181A2 (en) 2009-09-17
JP2011513485A (ja) 2011-04-28
USRE48825E1 (en) 2021-11-23
KR101610977B1 (ko) 2016-04-08
US20110112105A1 (en) 2011-05-12
US9199995B2 (en) 2015-12-01
DK2262505T3 (en) 2015-01-05
US20160194325A1 (en) 2016-07-07
KR20150140418A (ko) 2015-12-15
CN102046175A (zh) 2011-05-04
CA2716730A1 (en) 2009-09-17
PL2262505T3 (pl) 2015-04-30
IL289706A (en) 2022-03-01
AU2009223701A1 (en) 2009-09-17
KR20100122948A (ko) 2010-11-23
CN105237536A (zh) 2016-01-13
EP2262505A2 (en) 2010-12-22
ES2530090T3 (es) 2015-02-26
US9586960B2 (en) 2017-03-07
PT2262505E (pt) 2014-12-16
IL207772A0 (en) 2010-12-30
SI2262505T1 (sl) 2015-03-31
WO2009114181A3 (en) 2009-12-30
CA2716730C (en) 2017-05-16
EP2262505B1 (en) 2014-09-10
HK1152231A1 (en) 2012-02-24
MX347257B (es) 2017-04-20
IL263338A (en) 2018-12-31
US20140323491A1 (en) 2014-10-30
EP2262505A4 (en) 2012-03-07
US8648077B2 (en) 2014-02-11
AU2009223701B2 (en) 2015-04-16
HRP20141178T1 (hr) 2015-04-10
CN102046175B (zh) 2015-08-12

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