CA2716730C - Substituted heterocycle fused gamma-carbolines solid - Google Patents

Substituted heterocycle fused gamma-carbolines solid Download PDF

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Publication number
CA2716730C
CA2716730C CA2716730A CA2716730A CA2716730C CA 2716730 C CA2716730 C CA 2716730C CA 2716730 A CA2716730 A CA 2716730A CA 2716730 A CA2716730 A CA 2716730A CA 2716730 C CA2716730 C CA 2716730C
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Canada
Prior art keywords
salt crystal
disorder
salt
salt crystals
ray powder
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Active
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CA2716730A
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English (en)
French (fr)
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CA2716730A1 (en
Inventor
Lawrence P. Wennogle
John Tomesch
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of CA2716730A1 publication Critical patent/CA2716730A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CA2716730A 2008-03-12 2009-03-12 Substituted heterocycle fused gamma-carbolines solid Active CA2716730C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3606908P 2008-03-12 2008-03-12
US61/036,069 2008-03-12
PCT/US2009/001608 WO2009114181A2 (en) 2008-03-12 2009-03-12 Substituted heterocycle fused gamma-carbolines solid

Publications (2)

Publication Number Publication Date
CA2716730A1 CA2716730A1 (en) 2009-09-17
CA2716730C true CA2716730C (en) 2017-05-16

Family

ID=41065729

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2716730A Active CA2716730C (en) 2008-03-12 2009-03-12 Substituted heterocycle fused gamma-carbolines solid

Country Status (16)

Country Link
US (4) US8648077B2 (https=)
EP (1) EP2262505B1 (https=)
JP (1) JP5611846B2 (https=)
KR (2) KR20150140418A (https=)
CN (2) CN105237536A (https=)
AU (1) AU2009223701B2 (https=)
CA (1) CA2716730C (https=)
DK (1) DK2262505T3 (https=)
ES (1) ES2530090T3 (https=)
HR (1) HRP20141178T1 (https=)
IL (3) IL207772A0 (https=)
MX (2) MX2010010024A (https=)
PL (1) PL2262505T3 (https=)
PT (1) PT2262505E (https=)
SI (1) SI2262505T1 (https=)
WO (1) WO2009114181A2 (https=)

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US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
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CA2796756A1 (en) 2010-04-22 2011-10-27 Intra-Cellular Therapies, Inc. Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
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Also Published As

Publication number Publication date
MX2010010024A (es) 2010-11-09
WO2009114181A2 (en) 2009-09-17
JP5611846B2 (ja) 2014-10-22
JP2011513485A (ja) 2011-04-28
USRE48825E1 (en) 2021-11-23
KR101610977B1 (ko) 2016-04-08
US20110112105A1 (en) 2011-05-12
US9199995B2 (en) 2015-12-01
DK2262505T3 (en) 2015-01-05
US20160194325A1 (en) 2016-07-07
KR20150140418A (ko) 2015-12-15
CN102046175A (zh) 2011-05-04
CA2716730A1 (en) 2009-09-17
PL2262505T3 (pl) 2015-04-30
IL289706A (en) 2022-03-01
AU2009223701A1 (en) 2009-09-17
KR20100122948A (ko) 2010-11-23
CN105237536A (zh) 2016-01-13
EP2262505A2 (en) 2010-12-22
ES2530090T3 (es) 2015-02-26
US9586960B2 (en) 2017-03-07
PT2262505E (pt) 2014-12-16
IL207772A0 (en) 2010-12-30
SI2262505T1 (sl) 2015-03-31
WO2009114181A3 (en) 2009-12-30
EP2262505B1 (en) 2014-09-10
HK1152231A1 (en) 2012-02-24
MX347257B (es) 2017-04-20
IL263338A (en) 2018-12-31
US20140323491A1 (en) 2014-10-30
EP2262505A4 (en) 2012-03-07
US8648077B2 (en) 2014-02-11
AU2009223701B2 (en) 2015-04-16
HRP20141178T1 (hr) 2015-04-10
CN102046175B (zh) 2015-08-12

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