JP5583698B2 - プロテインキナーゼａｂｌおよびｓｒｃの阻害剤としてのアザインドール誘導体 - Google Patents

プロテインキナーゼａｂｌおよびｓｒｃの阻害剤としてのアザインドール誘導体 Download PDF

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JP5583698B2
JP5583698B2 JP2011549698A JP2011549698A JP5583698B2 JP 5583698 B2 JP5583698 B2 JP 5583698B2 JP 2011549698 A JP2011549698 A JP 2011549698A JP 2011549698 A JP2011549698 A JP 2011549698A JP 5583698 B2 JP5583698 B2 JP 5583698B2
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methyl
cancer
pyrrolo
compound
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JP2012517465A (ja
JP2012517465A5 (enExample
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アブデルアジズ・ヤスリ
グエナエル・シュヴ
セドリック・ボリー
ルイ・ドロン
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オリバーズ・ファルマ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011549698A 2009-02-12 2010-02-12 プロテインキナーゼａｂｌおよびｓｒｃの阻害剤としてのアザインドール誘導体 Expired - Fee Related JP5583698B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
US61/202,279 2009-02-12
FR0900631 2009-02-12
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src

Publications (3)

Publication Number Publication Date
JP2012517465A JP2012517465A (ja) 2012-08-02
JP2012517465A5 JP2012517465A5 (enExample) 2013-03-28
JP5583698B2 true JP5583698B2 (ja) 2014-09-03

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ID=40886859

Family Applications (1)

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JP2011549698A Expired - Fee Related JP5583698B2 (ja) 2009-02-12 2010-02-12 プロテインキナーゼａｂｌおよびｓｒｃの阻害剤としてのアザインドール誘導体

Country Status (15)

Country Link
US (1) US8580815B2 (enExample)
EP (1) EP2396325B1 (enExample)
JP (1) JP5583698B2 (enExample)
AU (1) AU2010212560B2 (enExample)
CA (1) CA2751478A1 (enExample)
DK (1) DK2396325T3 (enExample)
ES (1) ES2540962T3 (enExample)
FR (1) FR2941948B1 (enExample)
HR (1) HRP20150697T8 (enExample)
HU (1) HUE024989T2 (enExample)
PL (1) PL2396325T3 (enExample)
PT (1) PT2396325E (enExample)
SI (1) SI2396325T1 (enExample)
SM (1) SMT201500175B (enExample)
WO (1) WO2010092489A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2935248T3 (pl) * 2012-12-21 2018-07-31 Plexxikon Inc Związki i sposoby modulacji kinaz i wskazania dla nich
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
EP3601216B1 (en) * 2017-03-21 2023-10-25 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same for the treatment of hepatitis b virus infection
US11739088B2 (en) 2020-04-29 2023-08-29 Plexxikon Inc. Synthesis of heterocyclic compounds
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
EP4225741A4 (en) * 2020-10-05 2024-10-30 Enliven Inc. 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES
JP7588224B2 (ja) * 2020-10-05 2024-11-21 エンライブン インコーポレイテッド Ｂｃｒ－ａｂｌチロシンキナーゼの阻害のための５－及び６－アザインドール化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2006009755A2 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
WO2006015123A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7709645B2 (en) * 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7358256B2 (en) * 2005-03-28 2008-04-15 Bristol-Myers Squibb Company ATP competitive kinase inhibitors
EP2064213A1 (en) 2006-09-06 2009-06-03 F. Hoffmann-La Roche AG Heteroaryl derivatives as protein kinase inhibitors
EP2081928B1 (en) * 2006-11-10 2014-02-26 Bristol-Myers Squibb Company Pyrrolo-pyridine kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
WO2009111278A2 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
PT2344478T (pt) 2008-11-03 2017-11-28 Syntarga Bv Análogos de cc-1065 e seus conjugados

Also Published As

Publication number Publication date
CA2751478A1 (en) 2010-08-19
PT2396325E (pt) 2015-08-21
JP2012517465A (ja) 2012-08-02
PL2396325T3 (pl) 2015-10-30
AU2010212560B2 (en) 2016-01-21
EP2396325A1 (en) 2011-12-21
FR2941948B1 (fr) 2013-04-05
WO2010092489A1 (en) 2010-08-19
US8580815B2 (en) 2013-11-12
ES2540962T3 (es) 2015-07-15
FR2941948A1 (fr) 2010-08-13
HUE024989T2 (en) 2016-01-28
DK2396325T3 (en) 2015-06-29
SI2396325T1 (sl) 2015-08-31
EP2396325B1 (en) 2015-04-01
US20110312959A1 (en) 2011-12-22
HRP20150697T8 (xx) 2015-11-06
SMT201500175B (it) 2015-09-07
AU2010212560A1 (en) 2011-08-11
HRP20150697T1 (hr) 2015-08-14

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