PT2396325E - Derivados de azaindoles como inibidores das proteínacinases abl e src - Google Patents

Derivados de azaindoles como inibidores das proteínacinases abl e src Download PDF

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Publication number
PT2396325E
PT2396325E PT107104390T PT10710439T PT2396325E PT 2396325 E PT2396325 E PT 2396325E PT 107104390 T PT107104390 T PT 107104390T PT 10710439 T PT10710439 T PT 10710439T PT 2396325 E PT2396325 E PT 2396325E
Authority
PT
Portugal
Prior art keywords
azaindoles
src
inhibitors
derivatives
protein kinases
Prior art date
Application number
PT107104390T
Other languages
English (en)
Inventor
Abdelaziz Yasri
Gwénaël Cheve
Cédric Bories
Louis Delon
Original Assignee
Oribase Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oribase Pharma filed Critical Oribase Pharma
Publication of PT2396325E publication Critical patent/PT2396325E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT107104390T 2009-02-12 2010-02-12 Derivados de azaindoles como inibidores das proteínacinases abl e src PT2396325E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src

Publications (1)

Publication Number Publication Date
PT2396325E true PT2396325E (pt) 2015-08-21

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107104390T PT2396325E (pt) 2009-02-12 2010-02-12 Derivados de azaindoles como inibidores das proteínacinases abl e src

Country Status (15)

Country Link
US (1) US8580815B2 (pt)
EP (1) EP2396325B1 (pt)
JP (1) JP5583698B2 (pt)
AU (1) AU2010212560B2 (pt)
CA (1) CA2751478A1 (pt)
DK (1) DK2396325T3 (pt)
ES (1) ES2540962T3 (pt)
FR (1) FR2941948B1 (pt)
HR (1) HRP20150697T8 (pt)
HU (1) HUE024989T2 (pt)
PL (1) PL2396325T3 (pt)
PT (1) PT2396325E (pt)
SI (1) SI2396325T1 (pt)
SM (1) SMT201500175B (pt)
WO (1) WO2010092489A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105308036B (zh) * 2012-12-21 2019-06-21 普莱希科公司 用于激酶调节的化合物和方法及其适应症
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
MA49014A (fr) 2017-03-21 2020-02-05 Arbutus Biopharma Corp Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
IL301739A (en) 2020-10-05 2023-05-01 Enliven Therapeutics Inc 5- and 6-Azaindole compounds for inhibition of BCR-ABL tyrosine kinases
IL301740A (en) * 2020-10-05 2023-05-01 Enliven Therapeutics Inc 7-Azaindole compounds for inhibition of BCR-ABL tyrosine kinases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2006009755A2 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7709645B2 (en) 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
MX2007001127A (es) 2004-07-27 2007-07-11 Sgx Pharmaceuticals Inc Moduladores de pirrolo-piridina cinasa.
US7358256B2 (en) * 2005-03-28 2008-04-15 Bristol-Myers Squibb Company ATP competitive kinase inhibitors
EP2064213A1 (en) * 2006-09-06 2009-06-03 F. Hoffmann-La Roche AG Heteroaryl derivatives as protein kinase inhibitors
JP5244118B2 (ja) * 2006-11-10 2013-07-24 ブリストル−マイヤーズ スクイブ カンパニー 新規キナーゼ阻害剤
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
CL2009000447A1 (es) * 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
PL2344478T3 (pl) 2008-11-03 2018-02-28 Syntarga B.V. Analogi CC-1065 oraz ich koniugaty

Also Published As

Publication number Publication date
EP2396325B1 (en) 2015-04-01
EP2396325A1 (en) 2011-12-21
US20110312959A1 (en) 2011-12-22
CA2751478A1 (en) 2010-08-19
ES2540962T3 (es) 2015-07-15
JP5583698B2 (ja) 2014-09-03
AU2010212560B2 (en) 2016-01-21
FR2941948B1 (fr) 2013-04-05
AU2010212560A1 (en) 2011-08-11
HUE024989T2 (en) 2016-01-28
PL2396325T3 (pl) 2015-10-30
HRP20150697T8 (en) 2015-11-06
DK2396325T3 (en) 2015-06-29
SMT201500175B (it) 2015-09-07
WO2010092489A1 (en) 2010-08-19
JP2012517465A (ja) 2012-08-02
SI2396325T1 (sl) 2015-08-31
HRP20150697T1 (hr) 2015-08-14
FR2941948A1 (fr) 2010-08-13
US8580815B2 (en) 2013-11-12

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