SI2396325T1 - Derivati azaindola kot inhibitorji proteinskih kinaz abl in src - Google Patents

Derivati azaindola kot inhibitorji proteinskih kinaz abl in src

Info

Publication number
SI2396325T1
SI2396325T1 SI201030964T SI201030964T SI2396325T1 SI 2396325 T1 SI2396325 T1 SI 2396325T1 SI 201030964 T SI201030964 T SI 201030964T SI 201030964 T SI201030964 T SI 201030964T SI 2396325 T1 SI2396325 T1 SI 2396325T1
Authority
SI
Slovenia
Prior art keywords
azaindoles
src
inhibitors
derivatives
protein kinases
Prior art date
Application number
SI201030964T
Other languages
English (en)
Inventor
Abdelaziz Yasri
Gwenael Cheve
Cedric Bories
Louis Delon
Original Assignee
Oribase Pharma Rond Point Benjamin Franklin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oribase Pharma Rond Point Benjamin Franklin filed Critical Oribase Pharma Rond Point Benjamin Franklin
Publication of SI2396325T1 publication Critical patent/SI2396325T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201030964T 2009-02-12 2010-02-12 Derivati azaindola kot inhibitorji proteinskih kinaz abl in src SI2396325T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src
EP10710439.0A EP2396325B1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src

Publications (1)

Publication Number Publication Date
SI2396325T1 true SI2396325T1 (sl) 2015-08-31

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030964T SI2396325T1 (sl) 2009-02-12 2010-02-12 Derivati azaindola kot inhibitorji proteinskih kinaz abl in src

Country Status (15)

Country Link
US (1) US8580815B2 (sl)
EP (1) EP2396325B1 (sl)
JP (1) JP5583698B2 (sl)
AU (1) AU2010212560B2 (sl)
CA (1) CA2751478A1 (sl)
DK (1) DK2396325T3 (sl)
ES (1) ES2540962T3 (sl)
FR (1) FR2941948B1 (sl)
HR (1) HRP20150697T8 (sl)
HU (1) HUE024989T2 (sl)
PL (1) PL2396325T3 (sl)
PT (1) PT2396325E (sl)
SI (1) SI2396325T1 (sl)
SM (1) SMT201500175B (sl)
WO (1) WO2010092489A1 (sl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201504754QA (en) * 2012-12-21 2015-07-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
AU2018238138A1 (en) * 2017-03-21 2019-10-17 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
WO2022076973A1 (en) * 2020-10-05 2022-04-14 Enliven Therapeutics, Inc. 7-azaindole compounds for inhibition of bcr-abl tyrosine kinases
US11767321B2 (en) 2020-10-05 2023-09-26 Enliven Inc. 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Ｃ−ｋｉｔ活性を調節する化合物
US7709645B2 (en) * 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
MX2007001127A (es) 2004-07-27 2007-07-11 Sgx Pharmaceuticals Inc Moduladores de pirrolo-piridina cinasa.
WO2006104971A1 (en) * 2005-03-28 2006-10-05 Bristol-Myers Squibb Company Atp competitive kinase inhibitors
JP2010502660A (ja) * 2006-09-06 2010-01-28 エフ．ホフマン−ラ ロシュ アーゲー プロテインキナーゼインヒビターとしてのヘテロアリール誘導体
WO2008060907A2 (en) * 2006-11-10 2008-05-22 Bristol-Myers Squibb Company Pyrrolo-pyridine kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
CL2009000447A1 (es) * 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
HUE035798T2 (en) * 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates

Also Published As

Publication number Publication date
FR2941948B1 (fr) 2013-04-05
US20110312959A1 (en) 2011-12-22
ES2540962T3 (es) 2015-07-15
FR2941948A1 (fr) 2010-08-13
HUE024989T2 (en) 2016-01-28
PT2396325E (pt) 2015-08-21
AU2010212560A1 (en) 2011-08-11
EP2396325B1 (en) 2015-04-01
SMT201500175B (it) 2015-09-07
WO2010092489A1 (en) 2010-08-19
HRP20150697T8 (en) 2015-11-06
DK2396325T3 (en) 2015-06-29
CA2751478A1 (en) 2010-08-19
PL2396325T3 (pl) 2015-10-30
EP2396325A1 (en) 2011-12-21
JP5583698B2 (ja) 2014-09-03
HRP20150697T1 (hr) 2015-08-14
US8580815B2 (en) 2013-11-12
AU2010212560B2 (en) 2016-01-21
JP2012517465A (ja) 2012-08-02

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