FR2941948B1 - Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src - Google Patents

Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src

Info

Publication number
FR2941948B1
FR2941948B1 FR0900631A FR0900631A FR2941948B1 FR 2941948 B1 FR2941948 B1 FR 2941948B1 FR 0900631 A FR0900631 A FR 0900631A FR 0900631 A FR0900631 A FR 0900631A FR 2941948 B1 FR2941948 B1 FR 2941948B1
Authority
FR
France
Prior art keywords
src
inhibitor
abl kinase
kinase proteins
azaindole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0900631A
Other languages
English (en)
French (fr)
Other versions
FR2941948A1 (fr
Inventor
Abdelaziz Yasri
Gwenael Cheve
Cedric Bories
Louis Delon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOVA DECISION
Original Assignee
NOVA DECISION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0900631A priority Critical patent/FR2941948B1/fr
Application filed by NOVA DECISION filed Critical NOVA DECISION
Priority to US13/148,988 priority patent/US8580815B2/en
Priority to SI201030964T priority patent/SI2396325T1/sl
Priority to PT107104390T priority patent/PT2396325E/pt
Priority to ES10710439.0T priority patent/ES2540962T3/es
Priority to JP2011549698A priority patent/JP5583698B2/ja
Priority to HUE10710439A priority patent/HUE024989T2/en
Priority to PCT/IB2010/000593 priority patent/WO2010092489A1/en
Priority to AU2010212560A priority patent/AU2010212560B2/en
Priority to CA2751478A priority patent/CA2751478A1/en
Priority to EP10710439.0A priority patent/EP2396325B1/en
Priority to HRP20150697TT priority patent/HRP20150697T8/hr
Priority to PL10710439T priority patent/PL2396325T3/pl
Priority to DK10710439.0T priority patent/DK2396325T3/en
Publication of FR2941948A1 publication Critical patent/FR2941948A1/fr
Application granted granted Critical
Publication of FR2941948B1 publication Critical patent/FR2941948B1/fr
Priority to CY20151100553T priority patent/CY1116433T1/el
Priority to SM201500175T priority patent/SMT201500175B/xx
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0900631A 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src Expired - Fee Related FR2941948B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
EP10710439.0A EP2396325B1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src
PT107104390T PT2396325E (pt) 2009-02-12 2010-02-12 Derivados de azaindoles como inibidores das proteínacinases abl e src
ES10710439.0T ES2540962T3 (es) 2009-02-12 2010-02-12 Derivados de azaindoles como inhibidores de las proteína cinasas Abl y Src
JP2011549698A JP5583698B2 (ja) 2009-02-12 2010-02-12 プロテインキナーゼａｂｌおよびｓｒｃの阻害剤としてのアザインドール誘導体
HUE10710439A HUE024989T2 (en) 2009-02-12 2010-02-12 Azaindole derivatives as ABI and SRC protein kinase inhibitors
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src
AU2010212560A AU2010212560B2 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases Abl and Src
US13/148,988 US8580815B2 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases ABL and SRC
SI201030964T SI2396325T1 (sl) 2009-02-12 2010-02-12 Derivati azaindola kot inhibitorji proteinskih kinaz abl in src
HRP20150697TT HRP20150697T8 (xx) 2009-02-12 2010-02-12 Derivati azaindola kao inhibitori proteina kinaze abl i src
PL10710439T PL2396325T3 (pl) 2009-02-12 2010-02-12 Pochodne azaindoli jako inhibitory kinaz białkowych abl i src
DK10710439.0T DK2396325T3 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases ABL and SRC
CA2751478A CA2751478A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src
CY20151100553T CY1116433T1 (el) 2009-02-12 2015-06-29 Παραγωγα αζαϊνδολιων ως αναστολεις κινασων πρωτεϊνης abl και src
SM201500175T SMT201500175B (it) 2009-02-12 2015-07-22 Derivati di azaindoli come inibitori delle proteine chinasi abl e src

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src

Publications (2)

Publication Number Publication Date
FR2941948A1 FR2941948A1 (fr) 2010-08-13
FR2941948B1 true FR2941948B1 (fr) 2013-04-05

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0900631A Expired - Fee Related FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src

Country Status (15)

Country Link
US (1) US8580815B2 (enExample)
EP (1) EP2396325B1 (enExample)
JP (1) JP5583698B2 (enExample)
AU (1) AU2010212560B2 (enExample)
CA (1) CA2751478A1 (enExample)
DK (1) DK2396325T3 (enExample)
ES (1) ES2540962T3 (enExample)
FR (1) FR2941948B1 (enExample)
HR (1) HRP20150697T8 (enExample)
HU (1) HUE024989T2 (enExample)
PL (1) PL2396325T3 (enExample)
PT (1) PT2396325E (enExample)
SI (1) SI2396325T1 (enExample)
SM (1) SMT201500175B (enExample)
WO (1) WO2010092489A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9676748B2 (en) * 2012-12-21 2017-06-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2018172852A1 (en) * 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
CN115605460A (zh) 2020-04-29 2023-01-13 普莱希科公司（Us） 杂环化合物的合成
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
EP4225741A4 (en) * 2020-10-05 2024-10-30 Enliven Inc. 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES
US11767321B2 (en) 2020-10-05 2023-09-26 Enliven Inc. 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2006009755A2 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
MX2007001127A (es) 2004-07-27 2007-07-11 Sgx Pharmaceuticals Inc Moduladores de pirrolo-piridina cinasa.
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7709645B2 (en) * 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
DE602006004976D1 (de) * 2005-03-28 2009-03-12 Bristol Myers Squibb Co Kompetitive atp-kinasehemmer
CN101511828A (zh) 2006-09-06 2009-08-19 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的杂芳基衍生物
US8148361B2 (en) * 2006-11-10 2012-04-03 Bristol-Myers Squibb Company Kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
CA2716951A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
JP5677970B2 (ja) * 2008-11-03 2015-02-25 シンタルガ・ビーブイ 新規ｃｃ−１０６５類似体およびその複合体

Also Published As

Publication number Publication date
EP2396325B1 (en) 2015-04-01
US20110312959A1 (en) 2011-12-22
WO2010092489A1 (en) 2010-08-19
HUE024989T2 (en) 2016-01-28
FR2941948A1 (fr) 2010-08-13
ES2540962T3 (es) 2015-07-15
DK2396325T3 (en) 2015-06-29
EP2396325A1 (en) 2011-12-21
HRP20150697T1 (hr) 2015-08-14
CA2751478A1 (en) 2010-08-19
HRP20150697T8 (xx) 2015-11-06
SI2396325T1 (sl) 2015-08-31
US8580815B2 (en) 2013-11-12
JP5583698B2 (ja) 2014-09-03
PT2396325E (pt) 2015-08-21
AU2010212560A1 (en) 2011-08-11
JP2012517465A (ja) 2012-08-02
AU2010212560B2 (en) 2016-01-21
PL2396325T3 (pl) 2015-10-30
SMT201500175B (it) 2015-09-07

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Effective date: 20161028