AU2010212560B2 - Derivatives of azaindoles as inhibitors of protein kinases Abl and Src - Google Patents

Derivatives of azaindoles as inhibitors of protein kinases Abl and Src Download PDF

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Publication number
AU2010212560B2
AU2010212560B2 AU2010212560A AU2010212560A AU2010212560B2 AU 2010212560 B2 AU2010212560 B2 AU 2010212560B2 AU 2010212560 A AU2010212560 A AU 2010212560A AU 2010212560 A AU2010212560 A AU 2010212560A AU 2010212560 B2 AU2010212560 B2 AU 2010212560B2
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AU
Australia
Prior art keywords
group
methyl
pyrrolo
optionally mono
polysubstituted
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Ceased
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AU2010212560A
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AU2010212560A1 (en
Inventor
Cedric Bories
Gwenael Cheve
Louis Delon
Abdelaziz Yasri
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Oribase Pharma
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Oribase Pharma
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2010212560A 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases Abl and Src Ceased AU2010212560B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
US61/202,279 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
FR0900631 2009-02-12
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src

Publications (2)

Publication Number Publication Date
AU2010212560A1 AU2010212560A1 (en) 2011-08-11
AU2010212560B2 true AU2010212560B2 (en) 2016-01-21

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010212560A Ceased AU2010212560B2 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases Abl and Src

Country Status (15)

Country Link
US (1) US8580815B2 (enExample)
EP (1) EP2396325B1 (enExample)
JP (1) JP5583698B2 (enExample)
AU (1) AU2010212560B2 (enExample)
CA (1) CA2751478A1 (enExample)
DK (1) DK2396325T3 (enExample)
ES (1) ES2540962T3 (enExample)
FR (1) FR2941948B1 (enExample)
HR (1) HRP20150697T8 (enExample)
HU (1) HUE024989T2 (enExample)
PL (1) PL2396325T3 (enExample)
PT (1) PT2396325E (enExample)
SI (1) SI2396325T1 (enExample)
SM (1) SMT201500175B (enExample)
WO (1) WO2010092489A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015014752B1 (pt) * 2012-12-21 2022-07-05 Plexxikon, Inc Compostos e seus uso para modulação de cinase
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000493A1 (fr) 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
EP3601216B1 (en) 2017-03-21 2023-10-25 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same for the treatment of hepatitis b virus infection
AU2021263383A1 (en) 2020-04-29 2022-11-24 Plexxikon Inc. Synthesis of heterocyclic compounds
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
AU2021358123A1 (en) * 2020-10-05 2023-06-08 Enliven Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
JP2023545219A (ja) * 2020-10-05 2023-10-26 エンライブン インコーポレイテッド Ｂｃｒ－ａｂｌチロシンキナーゼの阻害のための７－アザインドール化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111278A2 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
WO2010062171A2 (en) * 2008-11-03 2010-06-03 Syntarga B.V. Novel cc-1065 analogs and their conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2006009797A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
JP2008508303A (ja) 2004-07-27 2008-03-21 エスジーエックス ファーマシューティカルズ、インコーポレイテッド ピロロ−ピリジンキナーゼモジュレーター
US7709645B2 (en) * 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
ES2319462T3 (es) * 2005-03-28 2009-05-07 Bristol-Myers Squibb Company Inhibidores competitivos de atp cinasas.
CN101511828A (zh) 2006-09-06 2009-08-19 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的杂芳基衍生物
US8148361B2 (en) * 2006-11-10 2012-04-03 Bristol-Myers Squibb Company Kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111278A2 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
US8338452B2 (en) * 2008-02-29 2012-12-25 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
WO2010062171A2 (en) * 2008-11-03 2010-06-03 Syntarga B.V. Novel cc-1065 analogs and their conjugates

Also Published As

Publication number Publication date
WO2010092489A1 (en) 2010-08-19
EP2396325A1 (en) 2011-12-21
HRP20150697T1 (hr) 2015-08-14
PT2396325E (pt) 2015-08-21
AU2010212560A1 (en) 2011-08-11
JP2012517465A (ja) 2012-08-02
SMT201500175B (it) 2015-09-07
CA2751478A1 (en) 2010-08-19
PL2396325T3 (pl) 2015-10-30
US20110312959A1 (en) 2011-12-22
HUE024989T2 (en) 2016-01-28
DK2396325T3 (en) 2015-06-29
JP5583698B2 (ja) 2014-09-03
SI2396325T1 (sl) 2015-08-31
US8580815B2 (en) 2013-11-12
FR2941948A1 (fr) 2010-08-13
FR2941948B1 (fr) 2013-04-05
HRP20150697T8 (xx) 2015-11-06
EP2396325B1 (en) 2015-04-01
ES2540962T3 (es) 2015-07-15

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