JP5576591B2 - α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤 - Google Patents

α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤 Download PDF

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Publication number
JP5576591B2
JP5576591B2 JP2007500529A JP2007500529A JP5576591B2 JP 5576591 B2 JP5576591 B2 JP 5576591B2 JP 2007500529 A JP2007500529 A JP 2007500529A JP 2007500529 A JP2007500529 A JP 2007500529A JP 5576591 B2 JP5576591 B2 JP 5576591B2
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day
cancer
ftd
administration
trifluorothymidine
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JP2007500529A
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Japanese (ja)
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JPWO2006080327A1 (ja
Inventor
智博 江村
明 三田
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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Priority claimed from US11/042,059 external-priority patent/US7799783B2/en
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP2007500529A priority Critical patent/JP5576591B2/ja
Publication of JPWO2006080327A1 publication Critical patent/JPWO2006080327A1/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007500529A 2005-01-26 2006-01-25 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤 Active JP5576591B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007500529A JP5576591B2 (ja) 2005-01-26 2006-01-25 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/042,059 US7799783B2 (en) 2005-01-26 2005-01-26 Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor
US11/042,059 2005-01-26
JP2005165156 2005-06-06
JP2005165156 2005-06-06
PCT/JP2006/301097 WO2006080327A1 (ja) 2005-01-26 2006-01-25 α，α，α－トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤
JP2007500529A JP5576591B2 (ja) 2005-01-26 2006-01-25 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤

Publications (2)

Publication Number Publication Date
JPWO2006080327A1 JPWO2006080327A1 (ja) 2008-06-19
JP5576591B2 true JP5576591B2 (ja) 2014-08-20

Family

ID=36740357

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JP2007500529A Active JP5576591B2 (ja) 2005-01-26 2006-01-25 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤

Country Status (21)

Country Link
EP (1) EP1849470B2 (Direct)
JP (1) JP5576591B2 (Direct)
KR (1) KR101468216B1 (Direct)
AU (1) AU2006209547C1 (Direct)
BE (1) BE2017C028I2 (Direct)
CA (1) CA2594713A1 (Direct)
CY (2) CY2017029I2 (Direct)
DK (1) DK1849470T4 (Direct)
ES (1) ES2630002T5 (Direct)
FI (1) FI1849470T4 (Direct)
FR (1) FR17C1028I2 (Direct)
HU (2) HUE033306T2 (Direct)
LT (2) LT1849470T (Direct)
LU (1) LUC00036I2 (Direct)
NL (1) NL300889I2 (Direct)
PL (1) PL1849470T5 (Direct)
PT (1) PT1849470T (Direct)
RU (1) RU2394581C2 (Direct)
SI (1) SI1849470T2 (Direct)
TW (1) TWI362265B (Direct)
WO (1) WO2006080327A1 (Direct)

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DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
CA2594713A1 (en) 2005-01-26 2006-08-03 Taiho Pharmaceutical Co., Ltd. Anticancer drug containing .alpha.,.alpha.,.alpha.-trifluorothymidine and thymidine phosphorylase inhibitor
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
ES2587381T3 (es) * 2007-04-25 2016-10-24 Cyclacel Limited Uso de sapacitabina para tratar una enfermedad proliferativa
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WO2009138507A2 (en) * 2008-05-15 2009-11-19 Katholieke Universiteit Leuven, K.U. Leuven R&D Anti-cancer combination therapy
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
WO2011009603A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids
BR112013005194A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo sal inorgânico
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
HRP20171458T1 (hr) 2011-07-29 2017-11-17 Grünenthal GmbH Tableta otporna na mijenjanje koja pruža neposredno oslobađanje lijeka
PE20141638A1 (es) 2011-07-29 2014-11-22 Gruenenthal Chemie Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
HUE035347T2 (en) 2011-08-16 2018-05-02 Taiho Pharmaceutical Co Ltd Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer
TWI503122B (zh) 2012-02-15 2015-10-11 Taiho Pharmaceutical Co Ltd Oral administration of pharmaceutical compositions
TWI526210B (zh) * 2012-02-15 2016-03-21 Taiho Pharmaceutical Co Ltd Oral pharmaceutical composition
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
WO2013137284A1 (ja) 2012-03-14 2013-09-19 日清ファルマ株式会社 含硫アミノ酸含有組成物
SI2838512T1 (sl) 2012-04-18 2018-11-30 Gruenenthal Gmbh Pred posegi in prehitrim sproščanjem odporna farmacevtska oblika odmerka
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
NZ700924A (en) 2012-05-16 2016-02-26 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
RS60958B1 (sr) * 2013-03-27 2020-11-30 Taiho Pharmaceutical Co Ltd Antitumorski agens koji uključuje irinotekan hidrohlorid hidrat
SMT201800677T1 (it) 2013-03-27 2019-01-11 Taiho Pharmaceutical Co Ltd Agente antitumorale includente irinotecano cloridrato idrato a basso dosaggio
TWI595879B (zh) 2013-05-17 2017-08-21 大鵬藥品工業股份有限公司 Prediction of therapeutic effect in patients with colorectal cancer with TK1 protein hyperactivity
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
WO2014191396A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
EA032465B1 (ru) 2013-07-12 2019-05-31 Грюненталь Гмбх Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления
RS64243B1 (sr) 2013-09-06 2023-06-30 Taiho Pharmaceutical Co Ltd Antitumorski agens i sredstvo za poboljšavanje antitumorskog efekta
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
AU2016319203A1 (en) 2015-09-10 2018-02-22 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
KR102281961B1 (ko) * 2016-01-08 2021-07-26 다이호야쿠힌고교 가부시키가이샤 면역 조절제를 함유하는 항종양제 및 항종양 효과 증강제
WO2017135412A1 (ja) * 2016-02-05 2017-08-10 大鵬薬品工業株式会社 重度腎機能障害を有する癌患者に対する治療方法
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EP3730935A4 (en) 2017-12-22 2022-02-23 Taiho Pharmaceutical Co., Ltd. METHOD OF DETECTING ANALOGUES OF TRIFLURIDIN AND/OR TIPIRACIL
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Also Published As

Publication number Publication date
EP1849470B2 (en) 2024-03-20
ES2630002T3 (es) 2017-08-17
CA2594713A1 (en) 2006-08-03
FR17C1028I2 (fr) 2018-11-02
FI1849470T4 (fi) 2024-03-22
EP1849470B1 (en) 2017-06-21
EP1849470A4 (en) 2010-12-08
SI1849470T2 (sl) 2024-05-31
ES2630002T5 (es) 2024-09-19
PL1849470T3 (pl) 2017-11-30
LUC00036I1 (Direct) 2017-10-02
LUC00036I2 (Direct) 2017-12-01
JPWO2006080327A1 (ja) 2008-06-19
AU2006209547B2 (en) 2011-05-26
NL300889I1 (nl) 2017-08-14
CY2017029I1 (el) 2018-02-14
PL1849470T5 (pl) 2024-06-10
NL300889I2 (nl) 2018-01-16
KR101468216B1 (ko) 2014-12-03
HUE033306T2 (hu) 2017-11-28
TWI362265B (en) 2012-04-21
LTC1849470I2 (lt) 2019-10-25
CY1119393T1 (el) 2018-02-14
DK1849470T3 (en) 2017-08-14
SI1849470T1 (sl) 2017-10-30
AU2006209547A1 (en) 2006-08-03
PT1849470T (pt) 2017-09-22
BE2017C028I2 (Direct) 2025-09-10
LTPA2017024I1 (lt) 2017-08-10
DK1849470T4 (en) 2024-04-02
FR17C1028I1 (Direct) 2017-09-29
KR20070104559A (ko) 2007-10-26
AU2006209547C1 (en) 2022-04-07
LT1849470T (lt) 2017-07-25
HUS1700032I1 (hu) 2017-09-28
RU2394581C2 (ru) 2010-07-20
WO2006080327A1 (ja) 2006-08-03
TW200637562A (en) 2006-11-01
EP1849470A1 (en) 2007-10-31
RU2007132181A (ru) 2009-03-10
CY2017029I2 (el) 2018-02-14

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