JP5572087B2 - キナーゼ阻害として有用なアミノピリミジン - Google Patents

キナーゼ阻害として有用なアミノピリミジン Download PDF

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Publication number
JP5572087B2
JP5572087B2 JP2010506664A JP2010506664A JP5572087B2 JP 5572087 B2 JP5572087 B2 JP 5572087B2 JP 2010506664 A JP2010506664 A JP 2010506664A JP 2010506664 A JP2010506664 A JP 2010506664A JP 5572087 B2 JP5572087 B2 JP 5572087B2
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JP
Japan
Prior art keywords
ring
cancer
compound
aliphatic
independently
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2010506664A
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Japanese (ja)
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JP2010526098A5 (en:Method
JP2010526098A (ja
Inventor
マイケル モーティモア，
ジュリアン ゴレク，
ダニエル ロビンソン，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010506664A 2007-05-02 2008-05-02 キナーゼ阻害として有用なアミノピリミジン Expired - Fee Related JP5572087B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91557907P 2007-05-02 2007-05-02
US60/915,579 2007-05-02
PCT/US2008/062330 WO2008137622A2 (en) 2007-05-02 2008-05-02 Aminopyrimidines useful as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013168846A Division JP2013231085A (ja) 2007-05-02 2013-08-15 キナーゼ阻害として有用なアミノピリミジン

Publications (3)

Publication Number Publication Date
JP2010526098A JP2010526098A (ja) 2010-07-29
JP2010526098A5 JP2010526098A5 (en:Method) 2012-06-07
JP5572087B2 true JP5572087B2 (ja) 2014-08-13

Family

ID=39708615

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010506664A Expired - Fee Related JP5572087B2 (ja) 2007-05-02 2008-05-02 キナーゼ阻害として有用なアミノピリミジン
JP2013168846A Withdrawn JP2013231085A (ja) 2007-05-02 2013-08-15 キナーゼ阻害として有用なアミノピリミジン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013168846A Withdrawn JP2013231085A (ja) 2007-05-02 2013-08-15 キナーゼ阻害として有用なアミノピリミジン

Country Status (8)

Country Link
US (1) US20110046104A1 (en:Method)
EP (1) EP2155730A2 (en:Method)
JP (2) JP5572087B2 (en:Method)
CN (1) CN101679387A (en:Method)
AU (1) AU2008247595A1 (en:Method)
CA (1) CA2688584A1 (en:Method)
MX (1) MX2009011811A (en:Method)
WO (1) WO2008137622A2 (en:Method)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013231085A (ja) * 2007-05-02 2013-11-14 Vertex Pharmaceuticals Inc キナーゼ阻害として有用なアミノピリミジン

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JP4105947B2 (ja) 2000-09-15 2008-06-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用なトリアゾール化合物
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7601718B2 (en) 2003-02-06 2009-10-13 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
JP5249770B2 (ja) 2005-11-03 2013-07-31 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリジン
ATE457311T1 (de) 2006-11-02 2010-02-15 Vertex Pharma Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
WO2008077086A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
WO2008112646A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
CA2680029A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
CN101663295B (zh) 2007-03-09 2014-11-05 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的氨基嘧啶类化合物
CA2683785A1 (en) 2007-04-13 2008-10-23 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
NZ580884A (en) 2007-05-02 2012-02-24 Vertex Pharma Thiazoles and pyrazoles useful as kinase inhibitors
AU2008247594A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
MX2010001137A (es) 2007-07-31 2010-03-31 Vertex Pharma Procesopara preparar 5-fluoro-1h-pirazol[3,4-b]piridin-3-amina y derivados del mismo.
SG10201704095UA (en) 2012-04-24 2017-06-29 Vertex Pharma Dna-pk inhibitors
CA2891412A1 (en) 2012-11-20 2014-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
ME03336B (me) 2013-03-12 2019-10-20 Vertex Pharma Inhibitori dnk-pk
DK3424920T3 (da) 2013-10-17 2020-06-08 Vertex Pharma Co-krystaller af (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinolin-4-carboxamid og deuterede derivater deraf som dna-pk-inhibitorer
TW201815418A (zh) 2016-09-27 2018-05-01 Vertex Pharma 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法
BR112020010120A2 (pt) * 2017-11-23 2020-11-10 Biomed X Gmbh compostos derivados de pirimidina e sua composição farmacêutica

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JP5572087B2 (ja) * 2007-05-02 2014-08-13 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害として有用なアミノピリミジン

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013231085A (ja) * 2007-05-02 2013-11-14 Vertex Pharmaceuticals Inc キナーゼ阻害として有用なアミノピリミジン

Also Published As

Publication number Publication date
CN101679387A (zh) 2010-03-24
EP2155730A2 (en) 2010-02-24
JP2013231085A (ja) 2013-11-14
WO2008137622A3 (en) 2009-03-05
AU2008247595A1 (en) 2008-11-13
MX2009011811A (es) 2010-01-14
WO2008137622A2 (en) 2008-11-13
US20110046104A1 (en) 2011-02-24
JP2010526098A (ja) 2010-07-29
CA2688584A1 (en) 2008-11-13

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