JP5571845B2 - フローサイトメーターにおいて複数のレーザービームを合波するための光学コンバイナ - Google Patents

フローサイトメーターにおいて複数のレーザービームを合波するための光学コンバイナ Download PDF

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JP5571845B2
JP5571845B2 JP2013509196A JP2013509196A JP5571845B2 JP 5571845 B2 JP5571845 B2 JP 5571845B2 JP 2013509196 A JP2013509196 A JP 2013509196A JP 2013509196 A JP2013509196 A JP 2013509196A JP 5571845 B2 JP5571845 B2 JP 5571845B2
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laser beam
laser
focus
lens
collimated
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JP2013527929A (ja
JP2013527929A5 (enExample
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ハンター，スーザン
エヌ． フォックス，ダニエル
サデー，ティダー
ジェー．ジー． オッテンベルグ，マティアス
ピー． ラレイ，ケヴィン
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バイオ−ラッド・ラボラトリーズ・インコーポレーテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/141—Beam splitting or combining systems operating by reflection only using dichroic mirrors

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Laser Beam Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013509196A 2010-05-03 2011-05-03 フローサイトメーターにおいて複数のレーザービームを合波するための光学コンバイナ Active JP5571845B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33084910P 2010-05-03 2010-05-03
US61/330,849 2010-05-03
PCT/US2011/035075 WO2011140153A1 (en) 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer

Publications (3)

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JP2013527929A JP2013527929A (ja) 2013-07-04
JP2013527929A5 JP2013527929A5 (enExample) 2014-06-19
JP5571845B2 true JP5571845B2 (ja) 2014-08-13

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JP2013509196A Active JP5571845B2 (ja) 2010-05-03 2011-05-03 フローサイトメーターにおいて複数のレーザービームを合波するための光学コンバイナ

Country Status (5)

Country Link
US (1) US8619370B2 (enExample)
EP (1) EP2567204B1 (enExample)
JP (1) JP5571845B2 (enExample)
CA (1) CA2797122C (enExample)
WO (1) WO2011140153A1 (enExample)

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* Cited by examiner, † Cited by third party
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EP2769203B1 (en) 2011-10-21 2019-01-16 Acea Biosciences, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
US10261080B2 (en) 2013-11-19 2019-04-16 Acea Biosciences, Inc. Optical detection system for flow cytometer, flow cytometer system and methods of use
CN105917211B (zh) * 2013-11-19 2019-03-19 艾森生物科学公司 用于流式细胞仪的光学引擎、流式细胞仪系统及使用方法
US9869628B2 (en) 2014-06-25 2018-01-16 Acea Biosciences, Inc. Methods of collecting cells from multi-well plates for use in flow cytometry
JP5719473B1 (ja) * 2014-09-25 2015-05-20 リオン株式会社 薬液用パーティクルカウンタ
WO2017060105A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Particle sensor for particle detection
KR20170079355A (ko) * 2015-12-30 2017-07-10 엘지이노텍 주식회사 발광 장치, 이 장치를 포함하는 광학 모듈, 및 이 모듈을 포함하는 차량
US10914913B2 (en) * 2018-03-30 2021-02-09 Idexx Laboratories, Inc. Flow cytometer, laser optics assembly thereof, and methods of assembling the same
CA3182847A1 (en) 2020-06-17 2021-12-23 Garland Christian Misener Flow cytometer and laser optics assembly thereof
CN116981927A (zh) * 2020-10-20 2023-10-31 贝克顿·迪金森公司 包括倾斜光束整形光学部件的流式细胞仪及其使用方法
JP7312793B2 (ja) * 2021-08-18 2023-07-21 京セラＳｏｃ株式会社 光源装置およびフローサイトメータ用レーザ光源装置

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US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
JPH0665979B2 (ja) * 1985-07-26 1994-08-24 東亜医用電子株式会社 光による粒子検出装置
JPH01196536A (ja) * 1988-02-01 1989-08-08 Canon Inc 粒子解析装置
JPH0296638A (ja) * 1988-10-03 1990-04-09 Canon Inc 光学装置及び該光学装置を用いた粒子測定装置
JPH0213830A (ja) * 1988-06-30 1990-01-18 Canon Inc 粒子測定装置
JPH03154850A (ja) * 1989-11-13 1991-07-02 Canon Inc 検体検査装置
WO2002017219A1 (en) 2000-08-25 2002-02-28 Amnis Corporation Measuring the velocity of small moving objects such as cells
US20070096039A1 (en) * 2002-05-03 2007-05-03 Rakesh Kapoor Evaluation Of Multicomponent Mixtures Using Modulated Light Beams
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7468789B2 (en) * 2004-02-05 2008-12-23 Advanced Analytical Technologies, Inc. Flow cytometer for rapid bacteria detection
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
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WO2006019052A1 (ja) * 2004-08-20 2006-02-23 Pioneer Corporation 光ピックアップ装置、情報記録再生装置
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JP4762593B2 (ja) 2005-04-05 2011-08-31 オリンパス株式会社 外部レーザ導入装置
JP4756948B2 (ja) * 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
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Also Published As

Publication number Publication date
US8619370B2 (en) 2013-12-31
JP2013527929A (ja) 2013-07-04
EP2567204A4 (en) 2018-01-17
US20120105967A1 (en) 2012-05-03
EP2567204B1 (en) 2021-12-29
CA2797122C (en) 2019-02-26
CA2797122A1 (en) 2011-11-10
WO2011140153A1 (en) 2011-11-10
EP2567204A1 (en) 2013-03-13

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