CA2797122C - Optical combiner for combining multiple laser beams in a flow cytometer - Google Patents

Optical combiner for combining multiple laser beams in a flow cytometer Download PDF

Info

Publication number
CA2797122C
CA2797122C CA2797122A CA2797122A CA2797122C CA 2797122 C CA2797122 C CA 2797122C CA 2797122 A CA2797122 A CA 2797122A CA 2797122 A CA2797122 A CA 2797122A CA 2797122 C CA2797122 C CA 2797122C
Authority
CA
Canada
Prior art keywords
laser
laser beam
lens
adjuster
size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2797122A
Other languages
English (en)
French (fr)
Other versions
CA2797122A1 (en
Inventor
Susan Hunter
Daniel N. Fox
Tidhar Sadeh
Matthias J. G. Ottenberg
Kevin P. Raley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of CA2797122A1 publication Critical patent/CA2797122A1/en
Application granted granted Critical
Publication of CA2797122C publication Critical patent/CA2797122C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/141—Beam splitting or combining systems operating by reflection only using dichroic mirrors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Laser Beam Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2797122A 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer Active CA2797122C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33084910P 2010-05-03 2010-05-03
US61/330,849 2010-05-03
PCT/US2011/035075 WO2011140153A1 (en) 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer

Publications (2)

Publication Number Publication Date
CA2797122A1 CA2797122A1 (en) 2011-11-10
CA2797122C true CA2797122C (en) 2019-02-26

Family

ID=44904046

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2797122A Active CA2797122C (en) 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer

Country Status (5)

Country Link
US (1) US8619370B2 (enExample)
EP (1) EP2567204B1 (enExample)
JP (1) JP5571845B2 (enExample)
CA (1) CA2797122C (enExample)
WO (1) WO2011140153A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2769203B1 (en) 2011-10-21 2019-01-16 Acea Biosciences, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
US10261080B2 (en) 2013-11-19 2019-04-16 Acea Biosciences, Inc. Optical detection system for flow cytometer, flow cytometer system and methods of use
CN105917211B (zh) * 2013-11-19 2019-03-19 艾森生物科学公司 用于流式细胞仪的光学引擎、流式细胞仪系统及使用方法
US9869628B2 (en) 2014-06-25 2018-01-16 Acea Biosciences, Inc. Methods of collecting cells from multi-well plates for use in flow cytometry
JP5719473B1 (ja) * 2014-09-25 2015-05-20 リオン株式会社 薬液用パーティクルカウンタ
WO2017060105A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Particle sensor for particle detection
KR20170079355A (ko) * 2015-12-30 2017-07-10 엘지이노텍 주식회사 발광 장치, 이 장치를 포함하는 광학 모듈, 및 이 모듈을 포함하는 차량
US10914913B2 (en) * 2018-03-30 2021-02-09 Idexx Laboratories, Inc. Flow cytometer, laser optics assembly thereof, and methods of assembling the same
CA3182847A1 (en) 2020-06-17 2021-12-23 Garland Christian Misener Flow cytometer and laser optics assembly thereof
CN116981927A (zh) * 2020-10-20 2023-10-31 贝克顿·迪金森公司 包括倾斜光束整形光学部件的流式细胞仪及其使用方法
JP7312793B2 (ja) * 2021-08-18 2023-07-21 京セラＳｏｃ株式会社 光源装置およびフローサイトメータ用レーザ光源装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408646A1 (de) * 1974-02-22 1975-08-28 Max Planck Gesellschaft Reaktionskinetisches messgeraet
US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
JPH0665979B2 (ja) * 1985-07-26 1994-08-24 東亜医用電子株式会社 光による粒子検出装置
JPH01196536A (ja) * 1988-02-01 1989-08-08 Canon Inc 粒子解析装置
JPH0296638A (ja) * 1988-10-03 1990-04-09 Canon Inc 光学装置及び該光学装置を用いた粒子測定装置
JPH0213830A (ja) * 1988-06-30 1990-01-18 Canon Inc 粒子測定装置
JPH03154850A (ja) * 1989-11-13 1991-07-02 Canon Inc 検体検査装置
WO2002017219A1 (en) 2000-08-25 2002-02-28 Amnis Corporation Measuring the velocity of small moving objects such as cells
US20070096039A1 (en) * 2002-05-03 2007-05-03 Rakesh Kapoor Evaluation Of Multicomponent Mixtures Using Modulated Light Beams
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7468789B2 (en) * 2004-02-05 2008-12-23 Advanced Analytical Technologies, Inc. Flow cytometer for rapid bacteria detection
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
EP1743576B1 (en) 2004-05-06 2018-01-24 Nippon Telegraph And Telephone Corporation Component concentration measuring device and method of controlling component concentration measuring device
WO2006019052A1 (ja) * 2004-08-20 2006-02-23 Pioneer Corporation 光ピックアップ装置、情報記録再生装置
JP4357399B2 (ja) * 2004-10-08 2009-11-04 株式会社日立ハイテクノロジーズ 電気泳動装置
JP4762593B2 (ja) 2005-04-05 2011-08-31 オリンパス株式会社 外部レーザ導入装置
JP4756948B2 (ja) * 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
US20090010589A1 (en) * 2005-08-30 2009-01-08 Robertson William M Optical sensor based on surface electromagnetic wave resonance in photonic band gap materials
JP2008254035A (ja) * 2007-04-05 2008-10-23 Disco Abrasive Syst Ltd レーザー加工装置
US7843561B2 (en) * 2007-12-17 2010-11-30 Accuri Cytometers, Inc. Optical system for a flow cytometer with an interrogation zone
JP4365439B2 (ja) * 2008-03-04 2009-11-18 三井造船株式会社 蛍光検出方法及び蛍光検出装置

Also Published As

Publication number Publication date
US8619370B2 (en) 2013-12-31
JP2013527929A (ja) 2013-07-04
JP5571845B2 (ja) 2014-08-13
EP2567204A4 (en) 2018-01-17
US20120105967A1 (en) 2012-05-03
EP2567204B1 (en) 2021-12-29
CA2797122A1 (en) 2011-11-10
WO2011140153A1 (en) 2011-11-10
EP2567204A1 (en) 2013-03-13

Similar Documents

Publication Publication Date Title
CA2797122C (en) Optical combiner for combining multiple laser beams in a flow cytometer
US11656429B2 (en) Systems, devices, and methods for automatic microscopic focus
US11067783B2 (en) Light sheet microscope and method for imaging a sample by light sheet microscopy
EP2202545A1 (en) Beam transformation module with an axicon in a double-pass mode
CN210548947U (zh) 一种变焦冲孔装置
CN105980912A (zh) 用于激光加工机的、用于激光射线的射线成形的光学组件
US20190341745A1 (en) Laser device
KR102313345B1 (ko) 광대역 광원 및 이를 구비하는 광학 검사장치
US9069167B2 (en) Illumination apparatus for microscope and microscope using the same
JP2017521729A (ja) ズーム顕微鏡
KR20080099582A (ko) 장거리용 적외선 레이저 조사기의 빔 크기 가변형 렌즈시스템
CN100485446C (zh) 激光处理装置
JP2018101092A (ja) ライトフィールド顕微鏡
US12339432B2 (en) Methods and systems for an adaptive illumination system for imaging applications
KR101667792B1 (ko) 간섭 빔을 이용한 절단용 광학기기
CN112904578A (zh) 一种流式细胞分选仪的照明系统和流式细胞分选仪
US12436399B2 (en) Multi-wavelength laser beam homogenizer-expander light engine
KR102425179B1 (ko) 라인빔 형성장치
CN118534632B (zh) 变焦照明装置、光学设备
CA3017188A1 (en) Optical integrator and illumination device using the same
US20240068926A1 (en) Adjustable aperture for flow cytometer
JP3530769B2 (ja) 照明装置及びそれを用いた光加工機
CN114488547A (zh) 用于流式细胞仪的光束整形系统
JP2003140034A (ja) 焦点検出装置及びそれを備えた光学顕微鏡又は光学検査装置

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160503