JP5559043B2 - 新規ヘテロ環化合物およびその使用 - Google Patents
新規ヘテロ環化合物およびその使用 Download PDFInfo
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- JP5559043B2 JP5559043B2 JP2010511212A JP2010511212A JP5559043B2 JP 5559043 B2 JP5559043 B2 JP 5559043B2 JP 2010511212 A JP2010511212 A JP 2010511212A JP 2010511212 A JP2010511212 A JP 2010511212A JP 5559043 B2 JP5559043 B2 JP 5559043B2
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US93378207P | 2007-06-07 | 2007-06-07 | |
| US60/933,782 | 2007-06-07 | ||
| PCT/US2008/007167 WO2008153974A1 (en) | 2007-06-07 | 2008-06-06 | Novel heterocycle compounds and uses thereof |
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| JP (2) | JP5559043B2 (OSRAM) |
| ES (1) | ES2607794T3 (OSRAM) |
| WO (1) | WO2008153974A1 (OSRAM) |
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| US8367686B2 (en) | 2007-06-07 | 2013-02-05 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| TW201103904A (en) * | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| JP6166534B2 (ja) * | 2009-08-05 | 2017-07-19 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規調節タンパク質および阻害剤 |
| CN107652269A (zh) * | 2016-07-26 | 2018-02-02 | 江苏豪森药业集团有限公司 | 甲磺酸氟马替尼中间体纯化方法 |
| CA3132730A1 (en) * | 2019-03-05 | 2020-09-10 | Hongyi & Associates Llc | Compounds for treating neurodegenerative diseases and cancers |
| CN116789643B (zh) * | 2023-06-25 | 2025-05-06 | 海南医学院 | 一种2-氨基嘧啶类化合物及其制备方法和应用 |
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| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| PT1635835E (pt) | 2003-06-13 | 2010-03-17 | Novartis Ag | Derivados de 2-aminopiridina como inibidores da raf-quinase |
| GB0325031D0 (en) * | 2003-10-27 | 2003-12-03 | Novartis Ag | Organic compounds |
| JP5520433B2 (ja) | 2004-01-21 | 2014-06-11 | エモリー ユニバーシティー | 病原体感染を処置するためのチロシンキナーゼインヒビターの組成物および使用 |
| JP2008510766A (ja) | 2004-08-27 | 2008-04-10 | ゲーペーツェー ビオテック アーゲー | ピリミジン誘導体 |
| CN1939910A (zh) * | 2004-12-31 | 2007-04-04 | 孙飘扬 | 氨基嘧啶类化合物及其盐和其制备方法与药物用途 |
| CN1972917B (zh) * | 2004-12-31 | 2010-08-25 | 孙飘扬 | 氨基嘧啶类化合物及其盐和其制备方法与药物用途 |
| US9062023B2 (en) * | 2007-06-07 | 2015-06-23 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| US8367686B2 (en) | 2007-06-07 | 2013-02-05 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| DK2365804T3 (en) | 2008-11-13 | 2015-07-27 | Modgene Llc | The reduction of amyloid-beta burden in tissues that are not derived from brain |
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2008
- 2008-06-06 US US12/663,224 patent/US9062023B2/en active Active
- 2008-06-06 EP EP08768240.7A patent/EP2166860B1/en not_active Not-in-force
- 2008-06-06 WO PCT/US2008/007167 patent/WO2008153974A1/en not_active Ceased
- 2008-06-06 JP JP2010511212A patent/JP5559043B2/ja not_active Expired - Fee Related
- 2008-06-06 ES ES08768240.7T patent/ES2607794T3/es active Active
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2014
- 2014-06-05 JP JP2014116664A patent/JP6017496B2/ja not_active Expired - Fee Related
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2015
- 2015-06-22 US US14/745,806 patent/US20160075683A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014193912A (ja) * | 2007-06-07 | 2014-10-09 | Intra-Cellular Therapies Inc | 新規ヘテロ環化合物およびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US9062023B2 (en) | 2015-06-23 |
| JP2010529132A (ja) | 2010-08-26 |
| EP2166860B1 (en) | 2016-09-21 |
| EP2166860A4 (en) | 2010-06-02 |
| ES2607794T3 (es) | 2017-04-04 |
| EP2166860A1 (en) | 2010-03-31 |
| US20100184778A1 (en) | 2010-07-22 |
| JP2014193912A (ja) | 2014-10-09 |
| WO2008153974A1 (en) | 2008-12-18 |
| JP6017496B2 (ja) | 2016-11-02 |
| US20160075683A1 (en) | 2016-03-17 |
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