JP5527206B2 - 炎症性腸疾患治療剤 - Google Patents
炎症性腸疾患治療剤 Download PDFInfo
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- JP5527206B2 JP5527206B2 JP2010517993A JP2010517993A JP5527206B2 JP 5527206 B2 JP5527206 B2 JP 5527206B2 JP 2010517993 A JP2010517993 A JP 2010517993A JP 2010517993 A JP2010517993 A JP 2010517993A JP 5527206 B2 JP5527206 B2 JP 5527206B2
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- acid
- present
- inflammatory bowel
- bowel disease
- compound
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- WJTCGQSWYFHTAC-UHFFFAOYSA-N cyclooctane Chemical group C1CCCCCCC1 WJTCGQSWYFHTAC-UHFFFAOYSA-N 0.000 description 1
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- 229960003444 immunosuppressant agent Drugs 0.000 description 1
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- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Chemical class 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-M leukotriene B4(1-) Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC([O-])=O VNYSSYRCGWBHLG-AMOLWHMGSA-M 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical class OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Chemical class 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
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- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
- 229960004963 mesalazine Drugs 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
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- 230000004677 mucosal permeability Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
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- 238000005498 polishing Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010517993A JP5527206B2 (ja) | 2008-06-23 | 2009-06-22 | 炎症性腸疾患治療剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008162640 | 2008-06-23 | ||
| JP2008162640 | 2008-06-23 | ||
| PCT/JP2009/061287 WO2009157398A1 (fr) | 2008-06-23 | 2009-06-22 | Agent thérapeutique pour une affection abdominale inflammatoire |
| JP2010517993A JP5527206B2 (ja) | 2008-06-23 | 2009-06-22 | 炎症性腸疾患治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2009157398A1 JPWO2009157398A1 (ja) | 2011-12-15 |
| JP5527206B2 true JP5527206B2 (ja) | 2014-06-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517993A Active JP5527206B2 (ja) | 2008-06-23 | 2009-06-22 | 炎症性腸疾患治療剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8394793B2 (fr) |
| EP (1) | EP2289518B1 (fr) |
| JP (1) | JP5527206B2 (fr) |
| KR (1) | KR101639821B1 (fr) |
| CN (1) | CN102065864B (fr) |
| CA (1) | CA2728161C (fr) |
| CY (1) | CY1118390T1 (fr) |
| DK (1) | DK2289518T3 (fr) |
| ES (1) | ES2611483T3 (fr) |
| HR (1) | HRP20170030T1 (fr) |
| HU (1) | HUE032108T2 (fr) |
| LT (1) | LT2289518T (fr) |
| PL (1) | PL2289518T3 (fr) |
| PT (1) | PT2289518T (fr) |
| SI (1) | SI2289518T1 (fr) |
| WO (1) | WO2009157398A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8791122B2 (en) | 2009-06-26 | 2014-07-29 | Nippon Shinyaku Co., Ltd. | Form-I crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide and method for producing the same |
| WO2011024874A1 (fr) * | 2009-08-26 | 2011-03-03 | 日本新薬株式会社 | Sels d'addition avec une base |
| CN104586853A (zh) * | 2014-12-31 | 2015-05-06 | 武汉联程生物科技有限公司 | 一种用于治疗外伤性颅脑创伤的药物组合物及其制备方法 |
| JP6825574B2 (ja) | 2015-12-02 | 2021-02-03 | 日本新薬株式会社 | ２−｛４−［ｎ−（５，６−ジフェニルピラジン−２−イル）−ｎ−イソプロピルアミノ］ブチルオキシ｝−ｎ−（メチルスルホニル）アセトアミドを含有する医薬組成物 |
| WO2018019296A1 (fr) * | 2016-07-29 | 2018-02-01 | 成都苑东生物制药股份有限公司 | Composé d'aminopyrazine, sel ou isomère, son procédé de préparation et son application |
| JOP20190204A1 (ar) | 2017-03-08 | 2019-09-05 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على سيليكسيباغ |
| EP4371617A2 (fr) | 2017-09-28 | 2024-05-22 | Nippon Shinyaku Co., Ltd. | Cristal |
| TW201922230A (zh) | 2017-11-16 | 2019-06-16 | 日商日本新藥股份有限公司 | 控釋製劑 |
| CN111699175B (zh) | 2018-02-07 | 2022-03-29 | 南京明德新药研发有限公司 | 前列环素受体受体激动剂 |
| CA3154802A1 (fr) | 2019-10-23 | 2021-04-29 | Marc Patrik SCHRADER | Composition pharmaceutique comprenant du selexipag |
| EP4096643A1 (fr) | 2020-01-31 | 2022-12-07 | Actelion Pharmaceuticals Ltd | Composition de sélexipag à libération contrôlée |
| TW202239408A (zh) | 2021-01-29 | 2022-10-16 | 瑞士商艾克泰聯製藥有限公司 | 包含二苯基吡𠯤衍生物的醫藥組成物 |
| TW202241425A (zh) | 2021-01-29 | 2022-11-01 | 瑞士商艾克泰聯製藥有限公司 | 用於製造二苯基吡𠯤衍生物之程序 |
| WO2023131608A1 (fr) | 2022-01-04 | 2023-07-13 | Actelion Pharmaceuticals Ltd | Compositions à libération contrôlée |
| WO2023214059A1 (fr) | 2022-05-06 | 2023-11-09 | Actelion Pharmaceuticals Ltd | Composés de diphénylpyrazine utilisés en tant que promédicaments |
| WO2024017964A1 (fr) | 2022-07-20 | 2024-01-25 | Actelion Pharmaceuticals Ltd | Composition pharmaceutique injectable comprenant un dérivé de diphénylpyrazine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10194992A (ja) * | 1996-12-30 | 1998-07-28 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
| WO2002088084A1 (fr) * | 2001-04-26 | 2002-11-07 | Nippon Shinyaku Co., Ltd. | Derives de composes heterocycliques et medicaments |
| WO2006055481A1 (fr) * | 2004-11-16 | 2006-05-26 | Allergan , Inc. | Cyclopentanones 2,3,4-substitues utilises comme agents therapeutiques |
| WO2006058080A1 (fr) * | 2004-11-29 | 2006-06-01 | Allergan, Inc. | Traitement de maladie enterique inflammatoire |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0908491A2 (pt) * | 2008-02-28 | 2015-08-11 | Nippon Shinyaku Co Ltd | Inibidor de fibrose |
-
2009
- 2009-06-22 SI SI200931585A patent/SI2289518T1/sl unknown
- 2009-06-22 WO PCT/JP2009/061287 patent/WO2009157398A1/fr active Application Filing
- 2009-06-22 KR KR1020107028238A patent/KR101639821B1/ko active IP Right Grant
- 2009-06-22 HU HUE09770108A patent/HUE032108T2/en unknown
- 2009-06-22 PT PT97701080T patent/PT2289518T/pt unknown
- 2009-06-22 LT LTEP09770108.0T patent/LT2289518T/lt unknown
- 2009-06-22 CA CA2728161A patent/CA2728161C/fr active Active
- 2009-06-22 CN CN2009801246843A patent/CN102065864B/zh active Active
- 2009-06-22 ES ES09770108.0T patent/ES2611483T3/es active Active
- 2009-06-22 PL PL09770108T patent/PL2289518T3/pl unknown
- 2009-06-22 US US13/000,791 patent/US8394793B2/en active Active
- 2009-06-22 EP EP09770108.0A patent/EP2289518B1/fr active Active
- 2009-06-22 DK DK09770108.0T patent/DK2289518T3/en active
- 2009-06-22 JP JP2010517993A patent/JP5527206B2/ja active Active
-
2016
- 2016-12-23 CY CY20161101341T patent/CY1118390T1/el unknown
-
2017
- 2017-01-10 HR HRP20170030TT patent/HRP20170030T1/hr unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10194992A (ja) * | 1996-12-30 | 1998-07-28 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
| WO2002088084A1 (fr) * | 2001-04-26 | 2002-11-07 | Nippon Shinyaku Co., Ltd. | Derives de composes heterocycliques et medicaments |
| WO2006055481A1 (fr) * | 2004-11-16 | 2006-05-26 | Allergan , Inc. | Cyclopentanones 2,3,4-substitues utilises comme agents therapeutiques |
| WO2006058080A1 (fr) * | 2004-11-29 | 2006-06-01 | Allergan, Inc. | Traitement de maladie enterique inflammatoire |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102065864B (zh) | 2012-11-21 |
| US20110118254A1 (en) | 2011-05-19 |
| HRP20170030T1 (hr) | 2017-03-24 |
| LT2289518T (lt) | 2017-01-10 |
| EP2289518A4 (fr) | 2012-04-11 |
| PT2289518T (pt) | 2016-11-18 |
| KR101639821B1 (ko) | 2016-07-14 |
| US8394793B2 (en) | 2013-03-12 |
| EP2289518B1 (fr) | 2016-11-02 |
| HUE032108T2 (en) | 2017-08-28 |
| JPWO2009157398A1 (ja) | 2011-12-15 |
| EP2289518A1 (fr) | 2011-03-02 |
| KR20110036537A (ko) | 2011-04-07 |
| DK2289518T3 (en) | 2017-01-16 |
| CA2728161C (fr) | 2017-06-06 |
| PL2289518T3 (pl) | 2017-03-31 |
| CA2728161A1 (fr) | 2009-12-30 |
| CN102065864A (zh) | 2011-05-18 |
| CY1118390T1 (el) | 2017-06-28 |
| SI2289518T1 (sl) | 2017-02-28 |
| ES2611483T3 (es) | 2017-05-09 |
| WO2009157398A1 (fr) | 2009-12-30 |
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