JP5524840B2 - チアジアジノン誘導体 - Google Patents
チアジアジノン誘導体 Download PDFInfo
- Publication number
- JP5524840B2 JP5524840B2 JP2010522210A JP2010522210A JP5524840B2 JP 5524840 B2 JP5524840 B2 JP 5524840B2 JP 2010522210 A JP2010522210 A JP 2010522210A JP 2010522210 A JP2010522210 A JP 2010522210A JP 5524840 B2 JP5524840 B2 JP 5524840B2
- Authority
- JP
- Japan
- Prior art keywords
- nha
- naa
- mixture
- atoms
- pharmaceutically usable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC=C(C)C=N[C@](c1cc(C(OC)=*)ccc1)N Chemical compound CC=C(C)C=N[C@](c1cc(C(OC)=*)ccc1)N 0.000 description 2
- SVIYBPNHRSNAKW-UHFFFAOYSA-N C=C(CSC(NN)=O)c1ncc[s]1 Chemical compound C=C(CSC(NN)=O)c1ncc[s]1 SVIYBPNHRSNAKW-UHFFFAOYSA-N 0.000 description 1
- BEBBILQNOWOSBM-UHFFFAOYSA-N CC1=CN=C(c2cc(CO)ccc2)N2C1C2 Chemical compound CC1=CN=C(c2cc(CO)ccc2)N2C1C2 BEBBILQNOWOSBM-UHFFFAOYSA-N 0.000 description 1
- PRAYXRLPTMXYEZ-UHFFFAOYSA-N COC(c1cccc(C(N)=N)c1)=O Chemical compound COC(c1cccc(C(N)=N)c1)=O PRAYXRLPTMXYEZ-UHFFFAOYSA-N 0.000 description 1
- XRMRCSFIUAANFS-UHFFFAOYSA-N Cc1cnc(-c2cccc(CN(C(SC3)=O)N=C3c3ncc[s]3)c2)nc1 Chemical compound Cc1cnc(-c2cccc(CN(C(SC3)=O)N=C3c3ncc[s]3)c2)nc1 XRMRCSFIUAANFS-UHFFFAOYSA-N 0.000 description 1
- WDDWONRQYJNBFH-UHFFFAOYSA-N Cc1nc(-c2cc(C(O)=N)ccc2)n[o]1 Chemical compound Cc1nc(-c2cc(C(O)=N)ccc2)n[o]1 WDDWONRQYJNBFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007041115A DE102007041115A1 (de) | 2007-08-30 | 2007-08-30 | Thiadiazinonderivate |
| DE102007041115.6 | 2007-08-30 | ||
| PCT/EP2008/006466 WO2009030333A1 (de) | 2007-08-30 | 2008-08-06 | Thiadiazinonderivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536896A JP2010536896A (ja) | 2010-12-02 |
| JP2010536896A5 JP2010536896A5 (OSRAM) | 2014-04-03 |
| JP5524840B2 true JP5524840B2 (ja) | 2014-06-18 |
Family
ID=39952448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522210A Expired - Fee Related JP5524840B2 (ja) | 2007-08-30 | 2008-08-06 | チアジアジノン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8211886B2 (OSRAM) |
| EP (1) | EP2181111B1 (OSRAM) |
| JP (1) | JP5524840B2 (OSRAM) |
| KR (1) | KR20100065171A (OSRAM) |
| CN (1) | CN101784544B (OSRAM) |
| AR (1) | AR068130A1 (OSRAM) |
| AU (1) | AU2008295193B2 (OSRAM) |
| BR (1) | BRPI0816058A2 (OSRAM) |
| CA (1) | CA2698062C (OSRAM) |
| DE (1) | DE102007041115A1 (OSRAM) |
| EA (1) | EA017393B1 (OSRAM) |
| ES (1) | ES2426356T3 (OSRAM) |
| IL (1) | IL204127A (OSRAM) |
| MX (1) | MX2010002096A (OSRAM) |
| WO (1) | WO2009030333A1 (OSRAM) |
| ZA (1) | ZA201002218B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US10398774B2 (en) | 2014-12-09 | 2019-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against AXL |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| DE4310699A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Thiadiazinone |
| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| PL194689B1 (pl) | 1996-02-13 | 2007-06-29 | Astrazeneca Uk Ltd | Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania |
| EP0885198B1 (en) | 1996-03-05 | 2001-12-19 | AstraZeneca AB | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| RU2209813C2 (ru) | 1997-11-19 | 2003-08-10 | Кова Ко., Лтд. | Производные пиридазина, лекарственные средства на их основе и способ лечения артрита |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EP1289952A1 (en) | 2000-05-31 | 2003-03-12 | AstraZeneca AB | Indole derivatives with vascular damaging activity |
| WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| CN1255391C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管破坏剂的colchinol衍生物 |
| CN1578665A (zh) | 2001-10-31 | 2005-02-09 | 默克专利股份公司 | 4型磷酸二脂酶抑制剂及其应用 |
| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| DE102005055355A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
-
2007
- 2007-08-30 DE DE102007041115A patent/DE102007041115A1/de not_active Withdrawn
-
2008
- 2008-08-06 WO PCT/EP2008/006466 patent/WO2009030333A1/de not_active Ceased
- 2008-08-06 JP JP2010522210A patent/JP5524840B2/ja not_active Expired - Fee Related
- 2008-08-06 CA CA2698062A patent/CA2698062C/en active Active
- 2008-08-06 US US12/675,412 patent/US8211886B2/en not_active Expired - Fee Related
- 2008-08-06 AU AU2008295193A patent/AU2008295193B2/en not_active Ceased
- 2008-08-06 CN CN2008801040992A patent/CN101784544B/zh not_active Expired - Fee Related
- 2008-08-06 KR KR1020107006823A patent/KR20100065171A/ko not_active Withdrawn
- 2008-08-06 MX MX2010002096A patent/MX2010002096A/es active IP Right Grant
- 2008-08-06 EP EP08785386.7A patent/EP2181111B1/de active Active
- 2008-08-06 ES ES08785386T patent/ES2426356T3/es active Active
- 2008-08-06 EA EA201000364A patent/EA017393B1/ru not_active IP Right Cessation
- 2008-08-06 BR BRPI0816058 patent/BRPI0816058A2/pt not_active IP Right Cessation
- 2008-08-29 AR ARP080103757A patent/AR068130A1/es unknown
-
2010
- 2010-02-23 IL IL204127A patent/IL204127A/en active IP Right Grant
- 2010-03-29 ZA ZA2010/02218A patent/ZA201002218B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR068130A1 (es) | 2009-11-04 |
| CA2698062C (en) | 2016-05-31 |
| CN101784544A (zh) | 2010-07-21 |
| JP2010536896A (ja) | 2010-12-02 |
| HK1146276A1 (en) | 2011-05-20 |
| BRPI0816058A2 (pt) | 2015-03-31 |
| KR20100065171A (ko) | 2010-06-15 |
| ZA201002218B (en) | 2010-12-29 |
| IL204127A (en) | 2013-08-29 |
| US8211886B2 (en) | 2012-07-03 |
| CN101784544B (zh) | 2012-08-29 |
| US20100311733A1 (en) | 2010-12-09 |
| EA201000364A1 (ru) | 2010-08-30 |
| EA017393B1 (ru) | 2012-12-28 |
| DE102007041115A1 (de) | 2009-03-05 |
| WO2009030333A1 (de) | 2009-03-12 |
| CA2698062A1 (en) | 2009-03-12 |
| EP2181111B1 (de) | 2013-06-26 |
| ES2426356T3 (es) | 2013-10-22 |
| AU2008295193B2 (en) | 2013-04-18 |
| MX2010002096A (es) | 2010-03-26 |
| EP2181111A1 (de) | 2010-05-05 |
| AU2008295193A1 (en) | 2009-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5443381B2 (ja) | Ｍｅｔキナーゼ阻害剤としての２−ベンジルピリダジノン誘導体 | |
| JP5426544B2 (ja) | ピリミジニル−ピリダジノン誘導体 | |
| JP5662143B2 (ja) | 腫瘍の処置のためのＭｅｔキナーゼ阻害剤としての２−オキソ−３−ベンジルベンゾキサゾール−２−オン誘導体、および関連する化合物 | |
| JP5576358B2 (ja) | ピリダジノン誘導体 | |
| JP5662325B2 (ja) | アザインドール誘導体 | |
| JP5592395B2 (ja) | ピリダジノン誘導体 | |
| JP5385262B2 (ja) | アリールエーテルピリダジノン誘導体 | |
| JP5485875B2 (ja) | ピリダジノン誘導体 | |
| JP5210172B2 (ja) | 腫瘍治療用のピリジアジノン誘導体 | |
| JP5475778B2 (ja) | 腫瘍の治療のための二環式トリアゾール誘導体 | |
| JP5662311B2 (ja) | Ｍｅｔキナーゼ阻害剤としての３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリダジン誘導体 | |
| JP2010536719A (ja) | ６−チオキソピリダジン誘導体 | |
| JP2012514613A (ja) | ピリダジノン誘導体 | |
| JP5174665B2 (ja) | １−アシルジヒドロピラゾール誘導体 | |
| JP5653933B2 (ja) | ベンゾチアゾロン誘導体 | |
| JP5227179B2 (ja) | ３，６−ジヒドロ−２−オキソ−６ｈ−１，３，４−チアジアジン誘導体 | |
| JP5524840B2 (ja) | チアジアジノン誘導体 | |
| JP5576395B2 (ja) | ３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ａ］ピリミジン誘導体 | |
| JP5643192B2 (ja) | 腫瘍を処置するためのチロシンキナーゼモジュレーターとしてのジヒドロピラゾール誘導体 | |
| JP5497783B2 (ja) | ３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリダジン誘導体 | |
| JP5683488B2 (ja) | ピリダジノン誘導体 | |
| HK1146276B (en) | Thiadiazinone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110805 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110805 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130514 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130814 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130910 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131210 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20131217 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140110 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140120 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20140210 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140311 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140410 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5524840 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D04 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |