JP5518082B2 - 吸入装置および医薬を投与する方法 - Google Patents
吸入装置および医薬を投与する方法 Download PDFInfo
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- JP5518082B2 JP5518082B2 JP2011530993A JP2011530993A JP5518082B2 JP 5518082 B2 JP5518082 B2 JP 5518082B2 JP 2011530993 A JP2011530993 A JP 2011530993A JP 2011530993 A JP2011530993 A JP 2011530993A JP 5518082 B2 JP5518082 B2 JP 5518082B2
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- actuator
- cavity
- foil
- ethyl
- inhaler
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- 238000000034 method Methods 0.000 title description 9
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- 238000000926 separation method Methods 0.000 claims description 46
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- 150000003839 salts Chemical class 0.000 claims description 16
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims description 5
- GHQXRNRNBBBEQN-UHFFFAOYSA-N n-cyclohexyl-3-[2-(3-fluorophenyl)ethylamino]-n-[2-[2-(4-hydroxy-2-oxo-3h-1,3-benzothiazol-7-yl)ethylamino]ethyl]propanamide Chemical compound C1=2SC(=O)NC=2C(O)=CC=C1CCNCCN(C(=O)CCNCCC=1C=C(F)C=CC=1)C1CCCCC1 GHQXRNRNBBBEQN-UHFFFAOYSA-N 0.000 claims description 5
- STTGOFBGRUQUOE-NDEPHWFRSA-N 2-[(4-chlorophenyl)methoxy]ethyl-[[2-[(r)-cyclohexyl-hydroxy-phenylmethyl]-1,3-oxazol-5-yl]methyl]-dimethylazanium Chemical class C=1N=C([C@@](O)(C2CCCCC2)C=2C=CC=CC=2)OC=1C[N+](C)(C)CCOCC1=CC=C(Cl)C=C1 STTGOFBGRUQUOE-NDEPHWFRSA-N 0.000 claims description 4
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Images
Classifications
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- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
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- A—HUMAN NECESSITIES
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- A61M15/0001—Details of inhalators; Constructional features thereof
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- A61M15/0025—Mouthpieces therefor with caps
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- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
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- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US61/103,606 | 2008-10-08 | ||
| PCT/SE2009/051110 WO2010042033A1 (en) | 2008-10-08 | 2009-10-07 | Inhalation device and method of dispensing medicament |
Publications (3)
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| JP2012505017A JP2012505017A (ja) | 2012-03-01 |
| JP2012505017A5 JP2012505017A5 (https=) | 2012-11-29 |
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| JP (1) | JP5518082B2 (https=) |
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| DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
| US9889087B2 (en) * | 2014-06-10 | 2018-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Intranasal delivery of β2-adrenergic receptor agonists for improving cognition in humans with down syndrome and compositions therefor |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| RU2018145364A (ru) | 2016-06-27 | 2020-07-28 | Ачиллион Фармасьютикалс, Инк. | Хиназолиновые и индольные соединения для лечения медицинских нарушений |
| GB201615186D0 (en) * | 2016-09-07 | 2016-10-19 | 3M Innovative Properties Co | Energy storage mechanism for an inhaler |
| GB2553534A (en) * | 2016-09-07 | 2018-03-14 | 3M Innovative Properties Co | Trigger mechanism for an inhaler |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| US11617842B2 (en) | 2017-03-15 | 2023-04-04 | Csp Technologies, Inc. | Inhaler and methods of using and making the same |
| CN110271772B (zh) * | 2018-03-13 | 2023-09-15 | 李和伟 | 一种给药器 |
| WO2020041301A1 (en) | 2018-08-20 | 2020-02-27 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| EP3866773B1 (en) | 2018-10-16 | 2024-08-28 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| US11229266B2 (en) | 2019-01-22 | 2022-01-25 | Coopervision International Limited | Tessellating blister packages for contact lenses |
| US11419397B2 (en) | 2019-01-22 | 2022-08-23 | Coopervision International Limited | Push-up contact lens blister package |
| US12053069B2 (en) | 2019-01-22 | 2024-08-06 | Coopervision International Limited | Contact lens blister package with double layer foil component |
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| US11267643B2 (en) | 2019-01-22 | 2022-03-08 | Coopervision International Limited | Contact lens dispenser |
| CN119837855A (zh) | 2019-12-19 | 2025-04-18 | 乔治亚州大学研究基金会 | 用于治疗细菌感染和增强抗生素的化合物 |
| WO2021168320A1 (en) | 2020-02-20 | 2021-08-26 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
| WO2022066774A1 (en) | 2020-09-23 | 2022-03-31 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9024760D0 (en) * | 1990-11-14 | 1991-01-02 | Riker Laboratories Inc | Inhalation device and medicament carrier |
| US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| JP2000503565A (ja) * | 1996-01-03 | 2000-03-28 | グラクソ、グループ、リミテッド | 吸入装置 |
| ATE432727T1 (de) | 1997-12-02 | 2009-06-15 | Valois Sas | Trockenpulverinhalator |
| NL1008031C2 (nl) * | 1998-01-15 | 1999-07-21 | Pharmachemie Bv | Inrichting voor het inhaleren van medicament. |
| GB9905538D0 (en) * | 1999-03-10 | 1999-05-05 | Glaxo Group Ltd | A device |
| AU1068401A (en) | 1999-10-12 | 2001-04-23 | Shl Medical Ab | Inhaler |
| US7171965B2 (en) | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
| WO2001072605A1 (en) | 2000-03-27 | 2001-10-04 | Dura Pharmaceuticals, Inc. | Containers for individual doses of an inhalable pharmaceutical |
| SE517227C2 (sv) | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator för torrt pulver med folieskärare |
| GB0120018D0 (en) * | 2001-08-16 | 2001-10-10 | Meridica Ltd | Pack containing medicament and dispensing device |
| CN1313171C (zh) * | 2001-09-19 | 2007-05-02 | 埃德文特药物有限公司 | 吸入器 |
| US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| GB0315509D0 (en) | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| GB0322544D0 (en) | 2003-09-26 | 2003-10-29 | Innovata Biomed Ltd | Apparatus |
| SE0401654D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | A support structure for a medicament |
| GB0426780D0 (en) | 2004-12-07 | 2005-01-12 | 3M Innovative Properties Co | Pressurized inhalation devices |
| CN101171182A (zh) * | 2005-05-02 | 2008-04-30 | 阿斯利康(瑞典)有限公司 | 用于开启凹部的装置和方法、医用密封包及分配设备 |
| BRPI0714463A2 (pt) | 2006-07-19 | 2013-04-02 | Astrazeneca Ab | compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina |
| WO2008101992A1 (en) * | 2007-02-21 | 2008-08-28 | Novo Nordisk A/S | Aerosol generating device with air flow control |
| GB0704928D0 (en) | 2007-03-14 | 2007-04-25 | Cambridge Consultants | Dry powder inhalers |
| HUE034380T2 (en) * | 2007-04-30 | 2018-02-28 | Sun Pharma Advanced Res Co Ltd | Inhalation device |
| WO2009008832A1 (en) | 2007-07-12 | 2009-01-15 | Astrazeneca Ab | Medicament containing structure, method and inhalation device comprising such structure |
| WO2009102276A1 (en) * | 2008-02-12 | 2009-08-20 | Astrazeneca Ab | Inhaler comprising a base having a plurality of medicament containing sealed cavities |
| KR20100129726A (ko) * | 2008-02-12 | 2010-12-09 | 아스트라제네카 아베 | 하나 이상의 밀봉된 의약 함유 캐비티를 가지는 기저부를 포함하는 흡입기 |
| JP5841429B2 (ja) * | 2008-10-08 | 2016-01-13 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | 可聴インジケータ手段を備えた吸入器 |
| JP5512686B2 (ja) * | 2008-10-08 | 2014-06-04 | アストラゼネカ・アクチエボラーグ | 呼吸作動式吸入器 |
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- 2009-10-07 ES ES09819487.1T patent/ES2579902T3/es active Active
- 2009-10-07 UA UAA201103725A patent/UA101056C2/ru unknown
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| AU2009302956B8 (en) | 2012-09-27 |
| CL2011000789A1 (es) | 2011-10-21 |
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| UA101056C2 (ru) | 2013-02-25 |
| CN102245239B (zh) | 2013-08-14 |
| IL212074A0 (en) | 2011-06-30 |
| BRPI0920658A2 (pt) | 2016-01-12 |
| NZ591956A (en) | 2012-11-30 |
| ES2579902T3 (es) | 2016-08-17 |
| EP2334358B1 (en) | 2016-02-10 |
| AU2009302956A1 (en) | 2010-04-15 |
| US9095670B2 (en) | 2015-08-04 |
| US20120125330A1 (en) | 2012-05-24 |
| EP2334358A4 (en) | 2014-04-02 |
| EA201100487A1 (ru) | 2011-12-30 |
| EP2334358A1 (en) | 2011-06-22 |
| AU2009302956B2 (en) | 2012-09-13 |
| CN102245239A (zh) | 2011-11-16 |
| JP2012505017A (ja) | 2012-03-01 |
| KR20110074766A (ko) | 2011-07-01 |
| MX2011003759A (es) | 2011-05-03 |
| CA2738822A1 (en) | 2010-04-15 |
| WO2010042033A1 (en) | 2010-04-15 |
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