JP5504460B2 - 4−フェニルアミノキナゾリン誘導体の塩形態 - Google Patents
4−フェニルアミノキナゾリン誘導体の塩形態 Download PDFInfo
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- JP5504460B2 JP5504460B2 JP2009549760A JP2009549760A JP5504460B2 JP 5504460 B2 JP5504460 B2 JP 5504460B2 JP 2009549760 A JP2009549760 A JP 2009549760A JP 2009549760 A JP2009549760 A JP 2009549760A JP 5504460 B2 JP5504460 B2 JP 5504460B2
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- C—CHEMISTRY; METALLURGY
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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CNA2007100375572A CN101245050A (zh) | 2007-02-14 | 2007-02-14 | 4-苯胺喹唑啉衍生物的盐 |
CN200710037557.2 | 2007-02-14 | ||
PCT/CN2008/000318 WO2008098485A1 (fr) | 2007-02-14 | 2008-02-04 | Sels de dérivé de 4-aniline quinazoline |
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JP2010518173A JP2010518173A (ja) | 2010-05-27 |
JP2010518173A5 JP2010518173A5 (ko) | 2011-04-07 |
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EP (1) | EP2116540B1 (ko) |
JP (1) | JP5504460B2 (ko) |
KR (1) | KR20100014947A (ko) |
CN (3) | CN101245050A (ko) |
AU (1) | AU2008215053B2 (ko) |
CA (1) | CA2677978C (ko) |
WO (1) | WO2008098485A1 (ko) |
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CN101347433B (zh) * | 2007-07-20 | 2012-05-02 | 江苏艾力斯生物医药有限公司 | 4-苯胺喹唑啉衍生物的制药用途 |
CN101544609A (zh) | 2008-03-25 | 2009-09-30 | 上海艾力斯医药科技有限公司 | 4-苯胺喹唑啉衍生物的结晶形式 |
CN101584696A (zh) * | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
SG11201805286RA (en) | 2015-12-24 | 2018-07-30 | Kyowa Hakko Kirin Co Ltd | α,β-UNSATURATED AMIDE COMPOUND |
CN106117182B (zh) * | 2016-06-20 | 2019-08-30 | 中国药科大学 | 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用 |
CN112225679A (zh) * | 2020-10-13 | 2021-01-15 | 苏州亚科科技股份有限公司 | 一种3-(环己胺)-2-羟基-1-丙磺酸的制备方法 |
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NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9800575D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
EP1100788B1 (en) | 1998-07-30 | 2005-11-09 | Wyeth | Substituted quinazoline derivatives |
HU229624B1 (en) * | 2000-06-30 | 2014-03-28 | Glaxo Group Ltd | Quinazoline ditosylate salt compounds |
KR100735639B1 (ko) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
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EP2116540B1 (en) | 2014-08-13 |
AU2008215053A1 (en) | 2008-08-21 |
CN104628658B (zh) | 2015-10-21 |
CN101245050A (zh) | 2008-08-20 |
CA2677978A1 (en) | 2008-08-21 |
CA2677978C (en) | 2015-04-07 |
AU2008215053B2 (en) | 2013-10-24 |
US8349854B2 (en) | 2013-01-08 |
KR20100014947A (ko) | 2010-02-11 |
JP2010518173A (ja) | 2010-05-27 |
EP2116540A1 (en) | 2009-11-11 |
WO2008098485A1 (fr) | 2008-08-21 |
EP2116540A4 (en) | 2010-04-28 |
CN101668750A (zh) | 2010-03-10 |
US20100168142A1 (en) | 2010-07-01 |
CN104628658A (zh) | 2015-05-20 |
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