JP5501615B2 - モルホリン化合物の塩 - Google Patents

モルホリン化合物の塩 Download PDF

Info

Publication number
JP5501615B2
JP5501615B2 JP2008524814A JP2008524814A JP5501615B2 JP 5501615 B2 JP5501615 B2 JP 5501615B2 JP 2008524814 A JP2008524814 A JP 2008524814A JP 2008524814 A JP2008524814 A JP 2008524814A JP 5501615 B2 JP5501615 B2 JP 5501615B2
Authority
JP
Japan
Prior art keywords
compound
methyl
dichlorobenzyl
morpholin
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008524814A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2008007691A1 (ja
Inventor
勝彦 増田
秀造 武田
善仁 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Priority to JP2008524814A priority Critical patent/JP5501615B2/ja
Publication of JPWO2008007691A1 publication Critical patent/JPWO2008007691A1/ja
Application granted granted Critical
Publication of JP5501615B2 publication Critical patent/JP5501615B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008524814A 2006-07-11 2007-07-11 モルホリン化合物の塩 Expired - Fee Related JP5501615B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008524814A JP5501615B2 (ja) 2006-07-11 2007-07-11 モルホリン化合物の塩

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006190437 2006-07-11
JP2006190437 2006-07-11
PCT/JP2007/063801 WO2008007691A1 (en) 2006-07-11 2007-07-11 Salt of morpholine compound
JP2008524814A JP5501615B2 (ja) 2006-07-11 2007-07-11 モルホリン化合物の塩

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013225889A Division JP2014015489A (ja) 2006-07-11 2013-10-30 モルホリン化合物の塩

Publications (2)

Publication Number Publication Date
JPWO2008007691A1 JPWO2008007691A1 (ja) 2009-12-10
JP5501615B2 true JP5501615B2 (ja) 2014-05-28

Family

ID=38923247

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008524814A Expired - Fee Related JP5501615B2 (ja) 2006-07-11 2007-07-11 モルホリン化合物の塩
JP2013225889A Pending JP2014015489A (ja) 2006-07-11 2013-10-30 モルホリン化合物の塩

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013225889A Pending JP2014015489A (ja) 2006-07-11 2013-10-30 モルホリン化合物の塩

Country Status (6)

Country Link
US (1) US8030303B2 (OSRAM)
EP (1) EP2042499B1 (OSRAM)
JP (2) JP5501615B2 (OSRAM)
ES (1) ES2687756T3 (OSRAM)
TW (1) TWI399375B (OSRAM)
WO (1) WO2008007691A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014015489A (ja) * 2006-07-11 2014-01-30 Mitsubishi Tanabe Pharma Corp モルホリン化合物の塩

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6382816B2 (ja) * 2013-07-24 2018-08-29 田辺三菱製薬株式会社 眼科疾患治療剤
WO2020203822A1 (ja) * 2019-03-29 2020-10-08 千寿製薬株式会社 血管新生を伴う網膜疾患の治療又は予防のための併用医薬

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005097120A (ja) * 2000-10-06 2005-04-14 Mochida Pharmaceut Co Ltd ４−ヒドロキシピペリジン誘導体の非潮解性塩
WO2006028284A1 (ja) * 2004-09-08 2006-03-16 Mitsubishi Pharma Corporation モルホリン化合物
JP2006514952A (ja) * 2002-12-23 2006-05-18 ハー・ルンドベック・アクチエゼルスカベット 臭化水素酸エスシタロプラム（ｅｓｃｉｔａｌｏｐｒａｍｈｙｄｒｏｂｒｏｍｉｄｅ）およびその製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101137880B1 (ko) 2004-12-31 2012-04-20 엘지디스플레이 주식회사 쉬프트 레지스터 및 그 구동 방법
JP5501615B2 (ja) * 2006-07-11 2014-05-28 田辺三菱製薬株式会社 モルホリン化合物の塩

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005097120A (ja) * 2000-10-06 2005-04-14 Mochida Pharmaceut Co Ltd ４−ヒドロキシピペリジン誘導体の非潮解性塩
JP2006514952A (ja) * 2002-12-23 2006-05-18 ハー・ルンドベック・アクチエゼルスカベット 臭化水素酸エスシタロプラム（ｅｓｃｉｔａｌｏｐｒａｍｈｙｄｒｏｂｒｏｍｉｄｅ）およびその製造方法
WO2006028284A1 (ja) * 2004-09-08 2006-03-16 Mitsubishi Pharma Corporation モルホリン化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN7012004075; 粟津荘司他，　最新薬剤学，　第７版，　２００１，　ｐ．１９９ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014015489A (ja) * 2006-07-11 2014-01-30 Mitsubishi Tanabe Pharma Corp モルホリン化合物の塩

Also Published As

Publication number Publication date
JPWO2008007691A1 (ja) 2009-12-10
US8030303B2 (en) 2011-10-04
TWI399375B (zh) 2013-06-21
JP2014015489A (ja) 2014-01-30
EP2042499A1 (en) 2009-04-01
EP2042499A4 (en) 2009-10-21
US20090264430A1 (en) 2009-10-22
EP2042499B1 (en) 2018-06-27
TW200817392A (en) 2008-04-16
ES2687756T3 (es) 2018-10-29
WO2008007691A1 (en) 2008-01-17

Similar Documents

Publication Publication Date Title
US8318723B2 (en) Pyrazine compounds, their use and methods of preparation
JP6008937B2 (ja) １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法
CA2806051C (en) Cyclic n,n'-diarylthioureas and n,n'-diarylureas - androgen receptor antagonists, anticancer agent, method for preparation and use thereof
JP2000501728A (ja) タキキニン受容体の拮抗薬としての３―ベンジルアミノピロリジン及び３―ベンジルアミノピペリジン
EA023955B1 (ru) Производное аминоалкилзамещенного n-тиенилбензамида
CN101595104A (zh) 作为glk活化剂的新的晶态化合物
JP7557500B2 (ja) 複素環誘導体化合物の製造方法、その化合物を含む組成物及びその化合物の水和物
MXPA06000850A (es) Compuesto de acido ciclohexancarboxilico.
US11932630B2 (en) Heteroaryl aminopropanol derivatives
WO2022237843A1 (zh) Axl抑制剂
JP5710490B2 (ja) （ｒ）−５−（（ｅ）−２−（ピロリジン−３−イルビニル）ピリミジンの合成および新規の塩形態
JP5501615B2 (ja) モルホリン化合物の塩
JP5282037B2 (ja) 新規なイソキノリン化合物の塩及びその結晶
CN104159584A (zh) 阿瑞吡坦l-脯氨酸溶剂化物-组合物和共晶体
WO2014034626A1 (ja) N-[2-({2-[(2S)-2-シアノピロリジン-1-イル]-2-オキソエチル}アミノ)-2-メチルプロピル]-2-メチルピラゾロ[1,5-a]ピリミジン-6-カルボキサミドの結晶
TW201206910A (en) Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
US9085539B2 (en) Cyclic N,N′-diarylthiourea—androgen receptor antagonist, anti breast cancer composition and use thereof
US20240182449A1 (en) Crystalline forms of an mk2 inhibitor
WO2015049667A1 (en) Novel compound as a diacylglycerol acyltransferase inhibitor
JP4435090B2 (ja) スルホンアミド含有インドール化合物の結晶およびその製造方法
BR122025013926A2 (pt) Ácidos carboxílicos de pirazolo piperidina substituídos, seu processo de preparação e medicamento
UA57089C2 (uk) Поліморфна форма 2-(r)-(1(r)-(3,5-біс(трифторметил)феніл)етокси)-3-(s)-(4-фтор)феніл-4-(3-(5-оксо-1h,4h-1,2,4-триазоло)метил)морфоліну як антагоніст рецептора тахікініну
JP2016094367A (ja) 新規ベンズイミダゾール化合物

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100602

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121009

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130115

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130730

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131030

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20131031

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20131126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A132

Effective date: 20140107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140117

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140212

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140312

R150 Certificate of patent or registration of utility model

Ref document number: 5501615

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees