JP5485172B2 - 新規な細胞増殖抑制性７−デアザプリンヌクレオシド - Google Patents

新規な細胞増殖抑制性７−デアザプリンヌクレオシド Download PDF

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JP5485172B2
JP5485172B2 JP2010542509A JP2010542509A JP5485172B2 JP 5485172 B2 JP5485172 B2 JP 5485172B2 JP 2010542509 A JP2010542509 A JP 2010542509A JP 2010542509 A JP2010542509 A JP 2010542509A JP 5485172 B2 JP5485172 B2 JP 5485172B2
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JP2011509949A5 (enExample
JP2011509949A (ja
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マイケル ホセク，
ペトル ナウス，
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インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー， アカデミー オブ サイエンシズ オブ ザ チェコ リパブリック
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00032—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by data exchange
    • H02J7/00036—Charger exchanging data with battery
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00047—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries with provisions for charging different types of batteries

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2010542509A 2008-01-18 2009-01-15 新規な細胞増殖抑制性７−デアザプリンヌクレオシド Active JP5485172B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2224708P 2008-01-18 2008-01-18
US61/022,247 2008-01-18
PCT/CZ2009/000004 WO2009089804A1 (en) 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides

Related Child Applications (1)

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JP2013266910A Division JP2014058567A (ja) 2008-01-18 2013-12-25 新規な細胞増殖抑制性７−デアザプリンヌクレオシド

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JP2011509949A JP2011509949A (ja) 2011-03-31
JP2011509949A5 JP2011509949A5 (enExample) 2013-02-21
JP5485172B2 true JP5485172B2 (ja) 2014-05-07

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JP2010542509A Active JP5485172B2 (ja) 2008-01-18 2009-01-15 新規な細胞増殖抑制性７−デアザプリンヌクレオシド
JP2013266910A Withdrawn JP2014058567A (ja) 2008-01-18 2013-12-25 新規な細胞増殖抑制性７−デアザプリンヌクレオシド

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JP2013266910A Withdrawn JP2014058567A (ja) 2008-01-18 2013-12-25 新規な細胞増殖抑制性７−デアザプリンヌクレオシド

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US (1) US8093226B2 (enExample)
EP (2) EP3133080B1 (enExample)
JP (2) JP5485172B2 (enExample)
CN (1) CN101977923B (enExample)
AU (1) AU2009204568B2 (enExample)
CA (1) CA2711384C (enExample)
CY (2) CY1118104T1 (enExample)
DK (2) DK3133080T3 (enExample)
ES (2) ES2693551T3 (enExample)
HR (2) HRP20161344T1 (enExample)
HU (2) HUE030767T2 (enExample)
LT (2) LT2231689T (enExample)
NZ (1) NZ586610A (enExample)
PL (2) PL3133080T3 (enExample)
PT (2) PT3133080T (enExample)
SI (2) SI3133080T1 (enExample)
TR (1) TR201815961T4 (enExample)
WO (1) WO2009089804A1 (enExample)

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KR20120030447A (ko) 2009-05-22 2012-03-28 인사이트 코포레이션 Ｊａｋ 저해물질로서 ３-［４-（７ｈ-피롤로［２,３-ｄ］피리미딘-４-일）-１ｈ-피라졸-１-일］옥탄- 또는 헵탄-니트릴
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EP2640725B1 (en) 2010-11-19 2015-01-07 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
PH12013501001A1 (en) 2010-11-19 2019-09-02 Incyte Holdings Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
AU2012273164B2 (en) 2011-06-20 2015-05-28 Incyte Holdings Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CR20190073A (es) 2012-11-15 2019-04-25 Incyte Holdings Corp FORMAS DE DOSIFICACIÓN DE RUXOLITINIB DE LIBERACIÓN SOTENIDA (Divisional 2015-265)
SMT202100694T1 (it) 2013-03-06 2022-03-21 Incyte Holdings Corp Procedimenti e intermedi per produrre un inibitore di jak
CA2920108C (en) 2013-08-07 2022-07-05 Incyte Corporation Sustained release dosage forms for a jak1 inhibitor
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
US10414788B2 (en) 2016-06-29 2019-09-17 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
EP3746429B1 (en) 2018-01-30 2022-03-09 Incyte Corporation Processes for preparing (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
MX2020010322A (es) 2018-03-30 2022-11-30 Incyte Corp Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
US20220152072A1 (en) * 2019-04-05 2022-05-19 Prelude Therapeutics, Incorporated Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
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CN115515593A (zh) * 2020-02-17 2022-12-23 勒芬天主教大学 作为药物的新的6-取代的7-脱氮嘌呤和相应的核苷
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AU2009204568A1 (en) 2009-07-23
DK2231689T3 (en) 2016-09-19
LT3133080T (lt) 2018-11-12
CN101977923B (zh) 2014-10-08
EP3133080A1 (en) 2017-02-22
WO2009089804A1 (en) 2009-07-23
NZ586610A (en) 2012-08-31
AU2009204568B2 (en) 2013-10-03
PT3133080T (pt) 2018-11-16
US20090203637A1 (en) 2009-08-13
HUE030767T2 (en) 2017-05-29
HUE041598T2 (hu) 2019-05-28
SI2231689T1 (sl) 2016-11-30
PT2231689T (pt) 2016-10-07
SI3133080T1 (sl) 2018-12-31
US8093226B2 (en) 2012-01-10
JP2014058567A (ja) 2014-04-03
EP2231689A1 (en) 2010-09-29
CN101977923A (zh) 2011-02-16
PL2231689T3 (pl) 2017-01-31
CA2711384C (en) 2016-07-26
HRP20161344T1 (hr) 2016-11-18
ES2598503T3 (es) 2017-01-27
CA2711384A1 (en) 2009-07-23
CY1121364T1 (el) 2020-05-29
CY1118104T1 (el) 2017-06-28
JP2011509949A (ja) 2011-03-31
TR201815961T4 (tr) 2018-11-21
EP3133080B1 (en) 2018-08-01
LT2231689T (lt) 2016-10-25
PL3133080T3 (pl) 2018-12-31
ES2693551T3 (es) 2018-12-12
DK3133080T3 (en) 2018-11-26
HRP20181774T1 (hr) 2018-12-28
EP2231689B1 (en) 2016-07-20

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