JP5483816B2 - アルツハイマー病に関する方法及び組成物 - Google Patents
アルツハイマー病に関する方法及び組成物 Download PDFInfo
- Publication number
- JP5483816B2 JP5483816B2 JP2007534083A JP2007534083A JP5483816B2 JP 5483816 B2 JP5483816 B2 JP 5483816B2 JP 2007534083 A JP2007534083 A JP 2007534083A JP 2007534083 A JP2007534083 A JP 2007534083A JP 5483816 B2 JP5483816 B2 JP 5483816B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- alzheimer
- disease
- differentially expressed
- precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421639.6A GB0421639D0 (en) | 2004-09-29 | 2004-09-29 | Methods and compositions relating to alzheimer's disease |
| GB0421639.6 | 2004-09-29 | ||
| PCT/GB2005/003756 WO2006035237A2 (en) | 2004-09-29 | 2005-09-29 | Methods and compositions relating to alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128088A Division JP5893269B2 (ja) | 2004-09-29 | 2011-06-08 | アルツハイマー病に関する方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514946A JP2008514946A (ja) | 2008-05-08 |
| JP5483816B2 true JP5483816B2 (ja) | 2014-05-07 |
Family
ID=33397455
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534083A Expired - Lifetime JP5483816B2 (ja) | 2004-09-29 | 2005-09-29 | アルツハイマー病に関する方法及び組成物 |
| JP2011128088A Expired - Lifetime JP5893269B2 (ja) | 2004-09-29 | 2011-06-08 | アルツハイマー病に関する方法及び組成物 |
| JP2014159434A Pending JP2014209132A (ja) | 2004-09-29 | 2014-08-05 | アルツハイマー病に関する方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128088A Expired - Lifetime JP5893269B2 (ja) | 2004-09-29 | 2011-06-08 | アルツハイマー病に関する方法及び組成物 |
| JP2014159434A Pending JP2014209132A (ja) | 2004-09-29 | 2014-08-05 | アルツハイマー病に関する方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7897361B2 (https=) |
| EP (3) | EP2562545A1 (https=) |
| JP (3) | JP5483816B2 (https=) |
| AT (1) | ATE495445T1 (https=) |
| AU (1) | AU2005288689B2 (https=) |
| CA (1) | CA2580532C (https=) |
| DE (1) | DE602005025897D1 (https=) |
| DK (1) | DK2354795T3 (https=) |
| GB (1) | GB0421639D0 (https=) |
| WO (1) | WO2006035237A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0421639D0 (en) * | 2004-09-29 | 2004-10-27 | Proteome Sciences Plc | Methods and compositions relating to alzheimer's disease |
| GB0426859D0 (en) * | 2004-12-07 | 2005-01-12 | Proteome Sciences Plc | Diagnosis of neurodegenerative disorders |
| GB2428240A (en) | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| GB0701626D0 (en) | 2007-01-22 | 2007-03-07 | Cambridge Entpr Ltd | Methods and biomarkers for diagnosing and monitoring psychotic disorders |
| AT506819B1 (de) | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
| EP2344881A4 (en) * | 2008-09-26 | 2012-03-07 | Univ Melbourne | BIOMARKER FOR MORBUS ALZHEIMER |
| IT1392551B1 (it) * | 2008-11-25 | 2012-03-09 | Bioindustry Park Del Canavese S P A | Biomarcatori per la diagnosi e per rilevare la progressione di malattie neurodegenerative, in particolare della sclerosi laterale amiotrofica |
| US20120071337A1 (en) | 2009-01-26 | 2012-03-22 | Electrophoretics Limited | Methods |
| JP2010271078A (ja) * | 2009-05-19 | 2010-12-02 | Mcbi:Kk | 認知機能障害疾患を含む精神疾患のバイオマーカーおよび該バイオマーカーを用いた認知機能障害疾患を含む精神疾患の検出方法 |
| AU2010202926B2 (en) * | 2009-09-11 | 2016-07-14 | Electrophoretics Limited | Markers and methods relating to the assessment of Alzheimer's disease |
| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| JP6012923B2 (ja) * | 2010-12-22 | 2016-10-25 | 株式会社Mcbi | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
| JP5906519B2 (ja) * | 2011-09-13 | 2016-04-20 | 国立大学法人 熊本大学 | 二次元電気泳動による蛋白質の分離方法 |
| JP2014533834A (ja) * | 2011-11-18 | 2014-12-15 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | トランスサイレチンおよびそのアイソフォームの定量化 |
| US9822170B2 (en) | 2012-02-22 | 2017-11-21 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer |
| WO2013148166A1 (en) | 2012-03-29 | 2013-10-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behlaf Of Arizona State University | Nanoscale process to generate reagents selective for individual protein variants |
| USRE49625E1 (en) | 2012-03-29 | 2023-08-29 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona | Nanoscale process to generate reagents selective for individual protein variants |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| WO2013153461A2 (en) | 2012-04-13 | 2013-10-17 | Oasis Diagnostics Corporation | Specific salivary biomarkers for risk detection, early diagnosis, prognosis and monitoring of alzheimer's and parkinson's diseases |
| WO2014040042A2 (en) | 2012-09-10 | 2014-03-13 | The Johns Hopkins University | Diagnostic assay for alzheimer's disease |
| WO2014055683A1 (en) * | 2012-10-03 | 2014-04-10 | The Research Foundation For The State University Of New York | Spectroscopic method for alzheimer's disease diagnosis |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| CA2902068C (en) * | 2013-02-28 | 2023-10-03 | Caprion Proteomics Inc. | Tuberculosis biomarkers and uses thereof |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| GB201310203D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Materials and methods relating to Alzheimer's disease |
| GB201310150D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Methods and compositions relating to alzheimer's disease |
| EP3039431A4 (en) * | 2013-08-27 | 2017-05-03 | CRC for Mental Health Ltd. | Method of identifying biomarkers of neurological diseases and diagnosis of neurological diseases |
| GB201322094D0 (en) | 2013-12-13 | 2014-01-29 | Electrophoretics Ltd | Methods and compositions relating to alzheimers disease |
| CA2936056A1 (en) * | 2014-01-06 | 2015-07-09 | Children's Medical Center Corporation | Biomarkers for dementia and dementia related neurological disorders |
| GB201403489D0 (en) * | 2014-02-27 | 2014-04-16 | Univ London Queen Mary | Biomarkers for endometriosis |
| US10639322B2 (en) * | 2015-03-27 | 2020-05-05 | The Research Foundation For The State University Of New York | Methods and materials for reducing amyloid beta levels within a mammal |
| US9904961B2 (en) | 2015-05-07 | 2018-02-27 | Kuwait University | System and method for determining the feedback capacity of information distributed in a complex network |
| JP6193942B2 (ja) * | 2015-09-09 | 2017-09-06 | 株式会社Mcbi | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
| CN105403649B (zh) * | 2015-12-01 | 2018-03-20 | 深圳大学 | 一种检测ad的尿液多肽组ad生物标记物 |
| JP6947451B2 (ja) * | 2016-06-29 | 2021-10-13 | 学校法人自治医科大学 | バイオマーカー、診断用組成物、及び診断用キット |
| JP6947450B2 (ja) * | 2016-06-29 | 2021-10-13 | 学校法人自治医科大学 | バイオマーカー、診断用組成物、及び診断用キット |
| WO2019013341A1 (ja) * | 2017-07-14 | 2019-01-17 | 株式会社島津製作所 | 疾患検出方法 |
| JP6408087B2 (ja) * | 2017-07-25 | 2018-10-17 | 株式会社Mcbi | 認知機能障害疾患のバイオマーカーおよび該バイオマーカーを用いる認知機能障害疾患の検出方法 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| CN113024651A (zh) * | 2019-12-25 | 2021-06-25 | 中国医学科学院药物研究所 | 阿尔茨海默病生物标志物及其应用 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| US20220260559A1 (en) * | 2020-11-04 | 2022-08-18 | Seer, Inc. | Biomarkers for diagnosing alzheimer's disease |
| CN115808492A (zh) * | 2021-09-14 | 2023-03-17 | 中国科学院深圳先进技术研究院 | 一种阿尔兹海默症生物标志物天冬酰胺及其应用 |
| EP4605754A1 (en) * | 2022-10-18 | 2025-08-27 | Immungenetics AG | Identifying a subject suffering from alzheimer's dementia or being at risk of developing alzheimer's dementia |
| CN117831756B (zh) * | 2024-03-05 | 2024-06-28 | 精智未来(广州)智能科技有限公司 | 一种认知障碍的辅助分析方法、装置、设备及存储介质 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US6342350B1 (en) * | 1997-09-05 | 2002-01-29 | The General Hospital Corporation | Alpha-2-macroglobulin diagnostic test |
| US20030211622A1 (en) | 1998-06-29 | 2003-11-13 | Roberts L. Jackson | Methods and compositions to assess oxidative brain injury |
| US20030131364A1 (en) * | 1999-04-27 | 2003-07-10 | Karen Duff | Method for producing transgenic animal models with modulated phenotype and animals produced therefrom |
| JP2001249128A (ja) * | 2000-03-06 | 2001-09-14 | Ikagaku:Kk | 動脈硬化症またはアルツハイマー病の診断用キット |
| US20020174447A1 (en) * | 2001-01-23 | 2002-11-21 | Greenspan Ralph J. | Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease |
| US6528309B2 (en) * | 2001-03-19 | 2003-03-04 | The Regents Of The University Of California | Vacuum-mediated desiccation protection of cells |
| US6451547B1 (en) * | 2001-04-25 | 2002-09-17 | Syn X Pharma | Process for differential diagnosis of Alzheimer's dementia and device therefor |
| DE10158180A1 (de) * | 2001-11-28 | 2003-09-11 | Biovision Ag | Verfahren zum Nachweis von Morbus Alzheimer und zur Unterscheidung von Morbus Alzheimer gegenüber anderen demenziellen Erkrankungen, zugehörige Peptide und deren Verwendung |
| WO2004001421A2 (en) * | 2002-06-21 | 2003-12-31 | Innogenetics N.V. | Method for the diagnosis and differential diagnosis of neurological diseases |
| US20070128596A1 (en) * | 2002-07-03 | 2007-06-07 | Roninson Igor B | Reagents and methods for identifying and modulating expression of tumor senescence genes |
| WO2004030522A2 (en) * | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
| KR100595494B1 (ko) * | 2003-02-24 | 2006-07-03 | (주) 디지탈바이오텍 | 혈액 내 베타-아밀로이드 항체 농도를 이용한 알츠하이머병 진단키트 |
| GB0421639D0 (en) * | 2004-09-29 | 2004-10-27 | Proteome Sciences Plc | Methods and compositions relating to alzheimer's disease |
-
2004
- 2004-09-29 GB GBGB0421639.6A patent/GB0421639D0/en not_active Ceased
-
2005
- 2005-09-29 EP EP12191625A patent/EP2562545A1/en not_active Withdrawn
- 2005-09-29 AU AU2005288689A patent/AU2005288689B2/en not_active Expired
- 2005-09-29 AT AT05788728T patent/ATE495445T1/de not_active IP Right Cessation
- 2005-09-29 DK DK10010288.8T patent/DK2354795T3/en active
- 2005-09-29 DE DE602005025897T patent/DE602005025897D1/de not_active Expired - Lifetime
- 2005-09-29 CA CA2580532A patent/CA2580532C/en not_active Expired - Lifetime
- 2005-09-29 WO PCT/GB2005/003756 patent/WO2006035237A2/en not_active Ceased
- 2005-09-29 EP EP10010288.8A patent/EP2354795B1/en not_active Expired - Lifetime
- 2005-09-29 EP EP05788728A patent/EP1794594B1/en not_active Expired - Lifetime
- 2005-09-29 JP JP2007534083A patent/JP5483816B2/ja not_active Expired - Lifetime
- 2005-09-29 US US11/664,076 patent/US7897361B2/en not_active Expired - Lifetime
-
2011
- 2011-01-12 US US13/005,121 patent/US20110165146A1/en not_active Abandoned
- 2011-06-08 JP JP2011128088A patent/JP5893269B2/ja not_active Expired - Lifetime
-
2014
- 2014-08-05 JP JP2014159434A patent/JP2014209132A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2354795B1 (en) | 2014-12-17 |
| US20080070995A1 (en) | 2008-03-20 |
| AU2005288689A1 (en) | 2006-04-06 |
| WO2006035237A2 (en) | 2006-04-06 |
| CA2580532A1 (en) | 2006-04-06 |
| JP2014209132A (ja) | 2014-11-06 |
| EP2354795A1 (en) | 2011-08-10 |
| DE602005025897D1 (de) | 2011-02-24 |
| AU2005288689B2 (en) | 2011-10-27 |
| ATE495445T1 (de) | 2011-01-15 |
| GB0421639D0 (en) | 2004-10-27 |
| EP2562545A1 (en) | 2013-02-27 |
| CA2580532C (en) | 2019-06-25 |
| JP2011209291A (ja) | 2011-10-20 |
| EP1794594B1 (en) | 2011-01-12 |
| EP1794594A2 (en) | 2007-06-13 |
| JP2008514946A (ja) | 2008-05-08 |
| DK2354795T3 (en) | 2015-02-16 |
| US7897361B2 (en) | 2011-03-01 |
| US20110165146A1 (en) | 2011-07-07 |
| JP5893269B2 (ja) | 2016-03-23 |
| WO2006035237A3 (en) | 2006-08-03 |
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