JP5483667B2 - 鱗片状リン酸水素カルシウムからなる制酸剤 - Google Patents
鱗片状リン酸水素カルシウムからなる制酸剤 Download PDFInfo
- Publication number
- JP5483667B2 JP5483667B2 JP2008172356A JP2008172356A JP5483667B2 JP 5483667 B2 JP5483667 B2 JP 5483667B2 JP 2008172356 A JP2008172356 A JP 2008172356A JP 2008172356 A JP2008172356 A JP 2008172356A JP 5483667 B2 JP5483667 B2 JP 5483667B2
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- JP
- Japan
- Prior art keywords
- hydrogen phosphate
- magnesium
- antacid
- calcium
- calcium hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 title claims description 64
- 229940069428 antacid Drugs 0.000 title claims description 46
- 239000003159 antacid agent Substances 0.000 title claims description 46
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims description 45
- 230000001458 anti-acid effect Effects 0.000 title claims description 34
- 235000019700 dicalcium phosphate Nutrition 0.000 title description 60
- 239000002245 particle Substances 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 230000002496 gastric effect Effects 0.000 claims description 9
- 102000038379 digestive enzymes Human genes 0.000 claims description 8
- 108091007734 digestive enzymes Proteins 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 229940124568 digestive agent Drugs 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 239000001095 magnesium carbonate Substances 0.000 claims description 7
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- PGZIKUPSQINGKT-UHFFFAOYSA-N dialuminum;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O PGZIKUPSQINGKT-UHFFFAOYSA-N 0.000 claims description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 6
- 230000000968 intestinal effect Effects 0.000 claims description 6
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 6
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 6
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000391 magnesium silicate Substances 0.000 claims description 6
- 235000019792 magnesium silicate Nutrition 0.000 claims description 6
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 239000000395 magnesium oxide Substances 0.000 claims description 5
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 5
- 235000012245 magnesium oxide Nutrition 0.000 claims description 5
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 5
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 5
- 239000003223 protective agent Substances 0.000 claims description 5
- 229940008027 aluminum hydroxide / magnesium carbonate Drugs 0.000 claims description 4
- 239000003485 histamine H2 receptor antagonist Substances 0.000 claims description 4
- 230000008439 repair process Effects 0.000 claims description 4
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims description 3
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims description 3
- 229940125714 antidiarrheal agent Drugs 0.000 claims description 3
- 239000003793 antidiarrheal agent Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 238000000975 co-precipitation Methods 0.000 claims description 3
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims description 3
- 229960001545 hydrotalcite Drugs 0.000 claims description 3
- 229910001701 hydrotalcite Inorganic materials 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims description 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 13
- 239000004083 gastrointestinal agent Substances 0.000 description 12
- -1 magnesium metasilicate aluminate Chemical class 0.000 description 11
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 10
- 229940043430 calcium compound Drugs 0.000 description 10
- 150000001674 calcium compounds Chemical class 0.000 description 10
- 229940127227 gastrointestinal drug Drugs 0.000 description 10
- 239000011164 primary particle Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000282485 Vulpes vulpes Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 150000007524 organic acids Chemical class 0.000 description 7
- 238000001694 spray drying Methods 0.000 description 7
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 235000011941 Tilia x europaea Nutrition 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000004571 lime Substances 0.000 description 6
- 235000013336 milk Nutrition 0.000 description 6
- 239000008267 milk Substances 0.000 description 6
- 210000004080 milk Anatomy 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 239000000292 calcium oxide Substances 0.000 description 5
- 235000012255 calcium oxide Nutrition 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 239000007884 disintegrant Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 239000011163 secondary particle Substances 0.000 description 5
- 239000002002 slurry Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229960002449 glycine Drugs 0.000 description 3
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 3
- 239000000347 magnesium hydroxide Substances 0.000 description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 3
- 235000012254 magnesium hydroxide Nutrition 0.000 description 3
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
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- 239000004094 surface-active agent Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 2
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 description 2
- 239000003699 antiulcer agent Substances 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 229910052797 bismuth Inorganic materials 0.000 description 2
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
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- 229960001380 cimetidine Drugs 0.000 description 2
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 2
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
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- RAOHHYUBMJLHNC-UHFFFAOYSA-N methixene hydrochloride Chemical compound [H+].O.[Cl-].C1N(C)CCCC1CC1C2=CC=CC=C2SC2=CC=CC=C21 RAOHHYUBMJLHNC-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
(1)平均粒子径0.05〜5μmの一次粒子からなる平均粒子径0.1〜500μmの凝集体であり、比表面積が5〜60m2/g、静的嵩比容積が1〜10ml/g、吸油量が0.5〜5ml/gである下式(I)
CaHPO4・mH2O (I)
(式中、mは0≦m≦0.5の範囲の数を示す)で示される鱗片状のリン酸水素カルシウムを有効成分とする制酸剤、
(2)凝集体が平均粒子径10〜500μmの粒子である(1)に記載の鱗片状のリン酸水素カルシウムを有効成分とする制酸剤、
(3)凝集体が平均粒子径0.1〜30μmの粉末である(1)に記載の鱗片状のリン酸水素カルシウムを有効成分とする制酸剤、
(4)請求項1〜3のいずれか1項に記載の制酸剤とその他の制酸剤が1:0.1〜3の割合で配合してなる消化管用医薬製剤であって、
その他の制酸剤が、炭酸水素ナトリウム、酸化マグネシウム、炭酸マグネシウム、ケイ酸マグネシウム、沈降炭酸カルシウム、ボレイ、ロートエキス、水酸化アルミニウム・炭酸マグネシウム混合乾燥ゲル、水酸化アルミニウムゲル、水酸化アルミニウム・炭酸マグネシウム・炭酸カルシウム共沈殿生成物、アルミニウムグリシネート、合成ヒドロタルサイト、合成ケイ酸アルミニウム、ケイ酸アルミン酸マグネシウム及びメタケイ酸アルミン酸マグネシウムから選ばれる1種以上である消化管用医薬製剤、
(5)H2遮断剤、健胃剤、消化剤、整腸剤、止瀉剤、粘膜修復剤、粘膜保護剤、生薬、消化酵素、菌製剤のいずれか1種以上を配合してなる請求項4に記載の消化管用医薬製剤。
本発明の鱗片状リン酸水素カルシウムの静的比容積は1〜20mlであり、好ましくは1〜10mlである。
本発明の鱗片状リン酸水素カルシウムの吸油量は0.5〜5ml/gであり、好ましくは0.5〜3mlである。
特に消化管用薬剤、胃に障害を与える活性成分及び胃酸抑制必要な活性成分とともに配合することが好ましい。
H2遮断剤としては、ファモチジン、ニザチジン、塩酸ラニチジン、シメチジン、塩酸ロキサチジンアセタートなどが挙げられる。
整腸剤としては、乳酸菌や納豆菌などの整腸菌成分、赤芽柏、アセンヤク、ウバイ、ケツメイシ、ゲンノショウコなどが挙げられる。
止瀉剤としては、アクリノール、塩化ベルベリン、次硝酸ビスマス、次炭酸ビスマス、カオリン、天然ケイ酸カルシウム、乳酸カルシウム、オウバクなどが挙げられる。
抗潰瘍剤としては、例えば、テプレノン、ファモチジン、ランソプラゾール、オメプラゾール、ラベプラゾール、シメチジン、塩酸ラニチジンなどが挙げられる。
その他の消化器官用薬としては、クエン酸モサプリドなどが挙げられる。
錠剤の製造方法は、顆粒状組成物を医薬品に配合可能な添加成分と乾式混合や湿式混合などの方法で混合したのち、圧縮成型する。このとき、F−MELT〔商標 富士化学工業(株)製〕、クロスポビドン、低置換度ヒドロキシプロピルセルロース、カルボキシメチルスターチナトリウム、クロスカルメロースナトリウム、澱粉などの崩壊剤を添加することによって、口腔内速崩壊剤とすることができる。
[SEM写真]
SEM(走査型顕微鏡)(日立製作所(株)、S−3000N)を用いて撮影した。
[粒子径測定方法]
懸濁液中の粒子の平均粒子径は、湿式粒度分布測定器(SALD−2000J、島津製作所(株)製)で屈折率1.7−0.20iの条件で平均粒子径を測定した。
乾式粉末の平均粒子径は、乾式粒度分布測定器(LA−920、(株)堀場製作所製)で平均粒子径を測定した。
[比表面積]
比表面積は、BET比表面積測定装置(モノソーブMS−17、ユアサアイオニクス(株)製)を用いて測定した。
[吸油量]
吸水量はJISK5101に基づき、アマニ油を用いて行った。
[静的比容積]
静的比容積は100mlのメスシリンダーにガラス管を挿入し、90〜100mlの容量となるようにロートで試料をガラス管内に入れ、ガラス管を静かに引き抜き、試料の表面を平らにしたときの容積(Vml)と試料の重量(Wg)をV/Wにより求めた。
フックス変法試験装置(pHメーター;HM−5S、東亜ディーケーケー(株)製)を用い、37℃±2℃、回転数300rpmに設定した0.1N−塩酸溶液50mlに試料を適量投入し、10分間pHの経時変化をレコーダーの記録し10分後のpH(最大pH)を読み取った。10分後より2.0ml/分の速度で0.1N−塩酸溶液を添加し、pHの経時変化をレコーダーに記録した。pHが下がりpH3.5及びpH3.0を切った時間を持続時間として記録した。
水3.4Lに撹拌しながら生石灰(CaO純度96%)340gを投入し、30分間撹拌して、石灰乳とし、この石灰乳を100メッシュで篩過し、粗粒物を除去した。室温〜40℃で撹拌しながら、この液に50%濃度のリン酸水溶液1.12kgと前述の手順で調製した石灰乳とを30分間で同時に添加した。そして30分間撹拌を続行して反応を完結させた。クエン酸一水和物12gを添加して95℃まで加温し、30分間保持した後、濾過・洗浄した。このケーキを乾燥してSEM写真を撮った(図1)。洗浄スラリーの濃度を16%w/wに調製し、噴霧乾燥機(LT−8型,大川原化工機(株)製)を用いて、入熱170℃、排熱110℃、アトマイザー回転数25,000rpmで乾燥し、鱗片状リン酸水素カルシウムの造粒物を得た。
水3.4Lに撹拌しながら生石灰(CaO純度96%)340gを投入し、30分間撹拌して、石灰乳とし、この石灰乳を100メッシュで篩過し、粗粒物を除去した。室温〜40℃で撹拌しながら、この液に50%濃度のリン酸水溶液1.12kgと前述の手順で調製した石灰乳とを30分間で同時に添加した。そして30分間撹拌を続行して反応を完結させた。95℃まで加温し、30分間保持した後、濾過・洗浄した。このケーキを乾燥してSEM写真を撮った(図2)。洗浄スラリーの濃度を16%w/wに調製し、噴霧乾燥機(LT−8型,大川原化工機(株)製)を用いて、入熱170℃、排熱110℃、アトマイザー回転数25,000rpmで乾燥し、リン酸水素カルシウムを得た。
各合成品を2.4g使用し、フックス試験を行った。
以下成分に水を同量添加して乳鉢で混合し、篩過後、50℃で一晩乾燥し、胃腸顆粒薬を製造した。
実施例1の鱗片状リン酸水素カルシウム 44.72重量%
水酸化マグネシウム 28.46重量%
コーンスターチ 6.82重量%
部分α化澱粉 20.00重量%
比較例1のリン酸水素カルシウムを用いた以外は、実施例2と同様に胃腸顆粒薬を製造した。
各胃腸顆粒薬を1.23g使用し、フックス試験を行った。
Claims (5)
- 平均粒子径0.05〜5μmの一次粒子からなる平均粒子径0.1〜500μmの凝集体であり、比表面積が5〜60m2/g、静的嵩比容積が1〜20ml/g、吸油量が0.5〜5ml/gである下式(I)
CaHPO4・mH2O (I)
(式中、mは0≦m≦0.5の範囲の数を示す)で表される鱗片状のリン酸水素カルシウムを有効成分とする制酸剤。 - 凝集体が平均粒子径10〜500μmの粒子である請求項1に記載の鱗片状のリン酸水素カルシウムを有効成分とする制酸剤。
- 凝集体が平均粒子径0.1〜30μmの粉末である請求項1に記載の鱗片状のリン酸水素カルシウムを有効成分とする制酸剤。
- 請求項1〜3のいずれか1項に記載の制酸剤とその他の制酸剤が1:0.1〜3の割合で配合してなる消化管用医薬製剤であって、
その他の制酸剤が、炭酸水素ナトリウム、酸化マグネシウム、炭酸マグネシウム、ケイ酸マグネシウム、沈降炭酸カルシウム、ボレイ、ロートエキス、水酸化アルミニウム・炭酸マグネシウム混合乾燥ゲル、水酸化アルミニウムゲル、水酸化アルミニウム・炭酸マグネシウム・炭酸カルシウム共沈殿生成物、アルミニウムグリシネート、合成ヒドロタルサイト、合成ケイ酸アルミニウム、ケイ酸アルミン酸マグネシウム及びメタケイ酸アルミン酸マグネシウムから選ばれる1種以上である消化管用医薬製剤。 - H2遮断剤、健胃剤、消化剤、整腸剤、止瀉剤、粘膜修復剤、粘膜保護剤、生薬、消化酵素、菌製剤のいずれか1種以上を配合してなる請求項4に記載の消化管用医薬製剤。
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