JP5469666B2 - ｃＭＥＴ阻害剤 - Google Patents

ｃＭＥＴ阻害剤 Download PDF

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Publication number
JP5469666B2
JP5469666B2 JP2011523198A JP2011523198A JP5469666B2 JP 5469666 B2 JP5469666 B2 JP 5469666B2 JP 2011523198 A JP2011523198 A JP 2011523198A JP 2011523198 A JP2011523198 A JP 2011523198A JP 5469666 B2 JP5469666 B2 JP 5469666B2
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JP
Japan
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alkyl
hetero
aryl
cycloalkyl
bicycloaryl
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Expired - Fee Related
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JP2011523198A
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Japanese (ja)
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JP2012500215A (ja
JP2012500215A5 (cg-RX-API-DMAC10.html
Inventor
ブレッシ、ジェローム、シー．
チュウ、シャオソン
エリクソン、フィリップ
コマンドラ、マーラレディ
クォック、リリー
ローソン、ジョン、ディー．
スタッフォード、ジェフリー、エー．
ウォーレス、マイケル、ビー．
ジャン、ジーユエン
ダス、サンジブ
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2011523198A 2008-08-14 2009-08-14 ｃＭＥＴ阻害剤 Expired - Fee Related JP5469666B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8895908P 2008-08-14 2008-08-14
US61/088,959 2008-08-14
US11791008P 2008-11-25 2008-11-25
US61/117,910 2008-11-25
US16100709P 2009-03-17 2009-03-17
US61/161,007 2009-03-17
PCT/US2009/053913 WO2010019899A1 (en) 2008-08-14 2009-08-14 cMET INHIBITORS

Publications (3)

Publication Number Publication Date
JP2012500215A JP2012500215A (ja) 2012-01-05
JP2012500215A5 JP2012500215A5 (cg-RX-API-DMAC10.html) 2012-09-06
JP5469666B2 true JP5469666B2 (ja) 2014-04-16

Family

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JP2011523198A Expired - Fee Related JP5469666B2 (ja) 2008-08-14 2009-08-14 ｃＭＥＴ阻害剤

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US (1) US8178534B2 (cg-RX-API-DMAC10.html)
EP (1) EP2313407B1 (cg-RX-API-DMAC10.html)
JP (1) JP5469666B2 (cg-RX-API-DMAC10.html)
KR (1) KR20110039383A (cg-RX-API-DMAC10.html)
CN (1) CN102124005B (cg-RX-API-DMAC10.html)
AR (1) AR072936A1 (cg-RX-API-DMAC10.html)
AU (1) AU2009281822B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0917808A2 (cg-RX-API-DMAC10.html)
CA (1) CA2731108A1 (cg-RX-API-DMAC10.html)
CO (1) CO6351724A2 (cg-RX-API-DMAC10.html)
CR (1) CR20110135A (cg-RX-API-DMAC10.html)
DO (1) DOP2011000050A (cg-RX-API-DMAC10.html)
EA (1) EA019723B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP11010889A (cg-RX-API-DMAC10.html)
ES (1) ES2608761T3 (cg-RX-API-DMAC10.html)
GE (1) GEP20125652B (cg-RX-API-DMAC10.html)
IL (1) IL210734A0 (cg-RX-API-DMAC10.html)
MA (1) MA32615B1 (cg-RX-API-DMAC10.html)
MX (1) MX2011001732A (cg-RX-API-DMAC10.html)
MY (1) MY150542A (cg-RX-API-DMAC10.html)
NZ (1) NZ590617A (cg-RX-API-DMAC10.html)
PE (1) PE20110275A1 (cg-RX-API-DMAC10.html)
TW (1) TWI455939B (cg-RX-API-DMAC10.html)
UY (1) UY32049A (cg-RX-API-DMAC10.html)
WO (1) WO2010019899A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201100467B (cg-RX-API-DMAC10.html)

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