JP5448448B2 - 同位体置換されたプロトンポンプインヒビター - Google Patents

同位体置換されたプロトンポンプインヒビター Download PDF

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Publication number
JP5448448B2
JP5448448B2 JP2008523354A JP2008523354A JP5448448B2 JP 5448448 B2 JP5448448 B2 JP 5448448B2 JP 2008523354 A JP2008523354 A JP 2008523354A JP 2008523354 A JP2008523354 A JP 2008523354A JP 5448448 B2 JP5448448 B2 JP 5448448B2
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Japan
Prior art keywords
methoxy
benzimidazole
compound
hydrogen
pyridinyl
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JP2008523354A
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English (en)
Japanese (ja)
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JP2009502871A5 (de
JP2009502871A (ja
Inventor
コール ベルンハルト
ミュラー ベルント
ハーグ ディーター
ジーモン ヴォルフガング−アレクサンダー
ツェッヒ カール
ダーヴィド ミヒャエル
フォン リヒター オリヴァー
フート フェリクス
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Takeda GmbH
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Takeda GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008523354A 2005-07-26 2006-07-26 同位体置換されたプロトンポンプインヒビター Expired - Fee Related JP5448448B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106868 2005-07-26
EP05106868.2 2005-07-26
PCT/EP2006/064666 WO2007012650A1 (en) 2005-07-26 2006-07-26 Isotopically substituted proton pump inhibitors

Publications (3)

Publication Number Publication Date
JP2009502871A JP2009502871A (ja) 2009-01-29
JP2009502871A5 JP2009502871A5 (de) 2012-12-20
JP5448448B2 true JP5448448B2 (ja) 2014-03-19

Family

ID=35734406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008523354A Expired - Fee Related JP5448448B2 (ja) 2005-07-26 2006-07-26 同位体置換されたプロトンポンプインヒビター

Country Status (16)

Country Link
EP (1) EP1910293A1 (de)
JP (1) JP5448448B2 (de)
KR (1) KR101358509B1 (de)
CN (2) CN102134232B (de)
AR (1) AR054584A1 (de)
AU (1) AU2006274036B2 (de)
BR (1) BRPI0614039A2 (de)
CA (1) CA2615670C (de)
EA (1) EA016814B1 (de)
IL (1) IL188773A (de)
MX (1) MX2008000901A (de)
NO (1) NO20080839L (de)
NZ (1) NZ565078A (de)
TW (1) TWI394750B (de)
WO (1) WO2007012650A1 (de)
ZA (1) ZA200800303B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006274037B2 (en) * 2005-07-26 2012-04-26 Takeda Gmbh Isotopically substituted pantoprazole
EP1934201A1 (de) * 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterierte hemmer von gastrischer h+, k+-atpase mit verstärkten therapeutischen eigenschaften
US20080255200A1 (en) * 2007-04-11 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
WO2008127640A2 (en) * 2007-04-11 2008-10-23 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
CA2789298A1 (en) 2010-02-12 2011-08-18 Esteve Quimica, S.A. Preparation process of the sodium salt of esomeprazole
CN104530003A (zh) * 2014-06-10 2015-04-22 广东东阳光药业有限公司 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
ES2293638T3 (es) * 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE10123129A1 (de) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10162121A1 (de) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
AU2006274037B2 (en) * 2005-07-26 2012-04-26 Takeda Gmbh Isotopically substituted pantoprazole

Also Published As

Publication number Publication date
AU2006274036A1 (en) 2007-02-01
IL188773A (en) 2014-02-27
AU2006274036B2 (en) 2012-05-24
AU2006274036A2 (en) 2008-03-20
ZA200800303B (en) 2009-01-28
KR101358509B1 (ko) 2014-02-05
NZ565078A (en) 2010-03-26
CA2615670C (en) 2015-01-20
CN101268051A (zh) 2008-09-17
CN102134232B (zh) 2012-11-21
CN102134232A (zh) 2011-07-27
EP1910293A1 (de) 2008-04-16
CN101268051B (zh) 2011-08-31
HK1160126A1 (en) 2012-08-10
KR20080037676A (ko) 2008-04-30
WO2007012650A1 (en) 2007-02-01
HK1125098A1 (en) 2009-07-31
NO20080839L (no) 2008-02-18
AR054584A1 (es) 2007-06-27
TW200714596A (en) 2007-04-16
EA016814B1 (ru) 2012-07-30
TWI394750B (zh) 2013-05-01
MX2008000901A (es) 2008-03-26
CA2615670A1 (en) 2007-02-01
BRPI0614039A2 (pt) 2011-03-09
EA200800203A1 (ru) 2008-08-29
IL188773A0 (en) 2008-08-07
JP2009502871A (ja) 2009-01-29

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