AR054584A1 - Inhibidores de la bomba de protones isotopicamente sustituidos - Google Patents

Inhibidores de la bomba de protones isotopicamente sustituidos

Info

Publication number
AR054584A1
AR054584A1 ARP060103224A ARP060103224A AR054584A1 AR 054584 A1 AR054584 A1 AR 054584A1 AR P060103224 A ARP060103224 A AR P060103224A AR P060103224 A ARP060103224 A AR P060103224A AR 054584 A1 AR054584 A1 AR 054584A1
Authority
AR
Argentina
Prior art keywords
replaced
alkoxy
alkyl
isotopically
proton pump
Prior art date
Application number
ARP060103224A
Other languages
English (en)
Inventor
Bernhard Kohl
Bernd Muller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Richter Oliver Von
Felix Huth
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of AR054584A1 publication Critical patent/AR054584A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Se refiere a bencimidazoles a composiciones farmacéuticas que comprenden estos compuestos, usos e intermediarios. Reivindicacion 1:Compuestos de la formula general (1) en la cual R1 es H o alcoxi C1-4; R2 es alquilo C1-4 o alcoxi C1-4; R3 es alquilo C1-4, alcoxi C1-4 o alcoxialcoxi C2-8; R4 es H o alquilo C1-4; Z es C-H o N, y sales, solvatos y solvatos de las sales de los mismos farmacéuticamente aceptables, en donde al menos un átomo de H de 1, R2, R3, R4 o cualquier combinacion de R1, R, R3 y R4 está reemplazado por un átomo de deuterio. Reivindicacion 2: Compuestos de la formula (2) en la cual R1 es H o alcoxi; R2 es alquilo C1-4 o alcoxi C1-4; R3 es alquilo C1-4, alcoxi C1-4 o alcoxialcoxi C2-8; R4 es H o alquilo C1-4; Z es C-H o N, y sales, solvatos y solvatos de las sales de los mismos farmacéuticamente aceptables, en donde al menos un átomo de H de 1, R2, R3, R4 o cualquier combinacion de R1, R, R3 y R4 está reemplazado por un átomo de deuterio.
ARP060103224A 2005-07-26 2006-07-26 Inhibidores de la bomba de protones isotopicamente sustituidos AR054584A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05106868 2005-07-26

Publications (1)

Publication Number Publication Date
AR054584A1 true AR054584A1 (es) 2007-06-27

Family

ID=35734406

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103224A AR054584A1 (es) 2005-07-26 2006-07-26 Inhibidores de la bomba de protones isotopicamente sustituidos

Country Status (17)

Country Link
EP (1) EP1910293A1 (es)
JP (1) JP5448448B2 (es)
KR (1) KR101358509B1 (es)
CN (2) CN101268051B (es)
AR (1) AR054584A1 (es)
AU (1) AU2006274036B2 (es)
BR (1) BRPI0614039A2 (es)
CA (1) CA2615670C (es)
EA (1) EA016814B1 (es)
HK (2) HK1125098A1 (es)
IL (1) IL188773A (es)
MX (1) MX2008000901A (es)
NO (1) NO20080839L (es)
NZ (1) NZ565078A (es)
TW (1) TWI394750B (es)
WO (1) WO2007012650A1 (es)
ZA (1) ZA200800303B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615678C (en) * 2005-07-26 2015-01-20 Nycomed Gmbh Isotopically substituted pantoprazole
AU2006299424A1 (en) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Deuterated inhibitors of gastric H+, K+-ATPase with enhanced therapeutic properties
WO2008127640A2 (en) * 2007-04-11 2008-10-23 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
WO2008130863A2 (en) * 2007-04-11 2008-10-30 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
JP5714031B2 (ja) 2010-02-12 2015-05-07 エステヴェ キミカ， エス．エー． エソメプラゾールナトリウムのナトリウム塩の調製方法
CN104530003A (zh) * 2014-06-10 2015-04-22 广东东阳光药业有限公司 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
JP3696884B2 (ja) * 1994-03-25 2005-09-21 アイソテクニカ、インコーポレーテッド ジュウテリウム化による薬物の効能の増強
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE10123129A1 (de) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10162121A1 (de) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
CA2615678C (en) * 2005-07-26 2015-01-20 Nycomed Gmbh Isotopically substituted pantoprazole

Also Published As

Publication number Publication date
AU2006274036B2 (en) 2012-05-24
IL188773A0 (en) 2008-08-07
CN101268051B (zh) 2011-08-31
EA016814B1 (ru) 2012-07-30
JP5448448B2 (ja) 2014-03-19
TWI394750B (zh) 2013-05-01
NZ565078A (en) 2010-03-26
CA2615670A1 (en) 2007-02-01
WO2007012650A1 (en) 2007-02-01
CN102134232A (zh) 2011-07-27
TW200714596A (en) 2007-04-16
BRPI0614039A2 (pt) 2011-03-09
AU2006274036A1 (en) 2007-02-01
AU2006274036A2 (en) 2008-03-20
EA200800203A1 (ru) 2008-08-29
HK1125098A1 (en) 2009-07-31
KR20080037676A (ko) 2008-04-30
CN101268051A (zh) 2008-09-17
CN102134232B (zh) 2012-11-21
ZA200800303B (en) 2009-01-28
NO20080839L (no) 2008-02-18
CA2615670C (en) 2015-01-20
MX2008000901A (es) 2008-03-26
IL188773A (en) 2014-02-27
JP2009502871A (ja) 2009-01-29
EP1910293A1 (en) 2008-04-16
KR101358509B1 (ko) 2014-02-05
HK1160126A1 (en) 2012-08-10

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