EP1910293A1 - Isotopensubstituierte protonenpumpenhemmer - Google Patents

Isotopensubstituierte protonenpumpenhemmer

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Publication number
EP1910293A1
EP1910293A1 EP06764258A EP06764258A EP1910293A1 EP 1910293 A1 EP1910293 A1 EP 1910293A1 EP 06764258 A EP06764258 A EP 06764258A EP 06764258 A EP06764258 A EP 06764258A EP 1910293 A1 EP1910293 A1 EP 1910293A1
Authority
EP
European Patent Office
Prior art keywords
methoxy
benzimidazole
trideuteriomethoxy
pyridinyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06764258A
Other languages
English (en)
French (fr)
Inventor
Bernhard Kohl
Bernd Müller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Oliver Von Richter
Felix Huth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Priority to EP06764258A priority Critical patent/EP1910293A1/de
Publication of EP1910293A1 publication Critical patent/EP1910293A1/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Definitions

  • the present invention relates to isotopically substituted proton pump inhibitors and their (R)- and (S)- enantiomers. These compounds can be used in the pharmaceutical industry for preparing pharmaceutical compositions.
  • R1 is hydrogen or 1-4C-alkoxy
  • 1-4C-Alkyl represents straight-chain or branched alkyl groups having 1 to 4 carbon atoms. Examples which may be mentioned are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and, preferably, the methyl group.
  • 1-4C-Alkoxy represents a group, which in addition to the oxygen atom contains one of the aforementioned 1-4C-alkyl groups or fluorinated 1-4C-alkyl groups.
  • 1-4C-alkyl groups which may be mentioned are the butoxy, isobutoxy, sec-butoxy, tert-butoxy, propoxy, isopropoxy, ethoxy and, preferably, the methoxy group.
  • fluorinated 1-4C-alkyl groups are 2,2,3,3,3- pentafluoropropyl, 2,2,3,3-tetrafluoropropyl, 1 -(trifluoromethyl)-2,2,2-trifluoroethyl, 2,2,3,3,4,4,4- heptafluorobutyl and, preferably, 2,2,2-trifluoroethyl and difluoromethyl.
  • Examples are meth- oxymethoxy, methoxyethoxy, ethoxymethoxy, ethoxypropoxy, ethoxyisopropoxy, isopropoxymethoxy, propoxymethoxy, methoxybutoxy, methoxyisobutoxy, propoxyethoxy, isopropoxyethoxy, propoxypro- poxy, isopropoxyisopropoxy, isopropoxypropoxy, propoxyisopropoxy, ethoxybutoxy, ethoxyisobutoxy, ethoxy-sec-butoxy, ethoxy-tert-butoxy and preferably methoxypropoxy.
  • salts with inorganic and organic bases are included, in particular the salts with alkali metals, such as the lithium, sodium and potassium salts, or the salts with alkaline earth metals, such as the magnesium and calcium salts, but also other pharmacologically compatible salts, such as, for example, the aluminium or the zinc salts.
  • alkali metals such as the lithium, sodium and potassium salts
  • alkaline earth metals such as the magnesium and calcium salts
  • other pharmacologically compatible salts such as, for example, the aluminium or the zinc salts.
  • the sodium and the magnesium salts are particularly preferred.
  • Pharmacologically incompatible salts which can initially be obtained, for example, as process products in the production of the compounds according to the invention on the industrial scale, which are also within the scope of the invention, are - for the production of pharmaceutical compositions - converted into the pharmacologically tolerable salts by processes known to the person skilled in the art.
  • the compounds according to the invention and their salts if, for example, they are isolated in crystalline form, can contain various amounts of solvents.
  • the invention therefore also comprises all solvates and in particular all hydrates of the compounds of the formula 1 , and also all solvates and in particular all hydrates of the salts of the compounds of the formula 1.
  • solvates all pharmaceutically acceptable solvents resulting in such solvates are included.
  • deutero or “deuterio” should indicate a deuterium atom ([ 2 H]).
  • pre-terms bis” or “di” and “tri” or “tris”, respectively should indicate the occurrence of two or three, for example deuterio atoms in a specific group, i.e. 1 ,1-dideuterio-2,2,2-trifluoroethoxy or trideuteriomethoxy .
  • R3 is replaced by a deuterium atom and R3 is a 1-2C alkoxy group or a 2-5C- alkoxyalkoxy group.
  • R2 is a 1-4C alkyl group and R3 is a 2-8C-alkoxyalkoxy group, wherein at least one of the hydrogen atoms of R2, R3 or R2 and R3 is replaced by a deuterium atom.
  • R1 is a 1-4C alkoxy group
  • R2 and R4 are a 1-4C alkyl group
  • R3 is a 1 -4C-alkoxy group, wherein at least one of the hydrogen atoms of R1 , R3, R4 or any combination of R1 , R3 and R4 is replaced by a deuterium atom.
  • R1 is hydrogen, methoxy or difluoromethoxy
  • R2 is methyl or methoxy
  • R3 is methoxy, 2,2,2-trifluoroethoxy or methoxypropoxy
  • R4 is hydrogen or methyl and wherein at least one of the hydrogen atoms of R3 is replaced by a deuterium atom.
  • R2 is methyl, R3 is methoxypropoxy and Z is C- H, wherein at least one of the hydrogen atoms of R2, R3 or R2 and R3 is replaced by a deuterium atom.
  • R2 is a 1-4C alkyl group and R3 is a 2-8C- alkoxyalkoxy group, wherein all hydrogen atoms of R2, R3 or R2 and R3 are replaced by deuterium atoms.
  • R1 is a 1 -4C alkoxy group
  • R2 and R4 are a 1 -4C alkyl group
  • R3 is a 1-4C-alkoxy group, wherein all hydrogen atoms of R1 , R3, R4 or any combination of R1 , R3 and R4 are replaced by deuterium atoms.
  • Possible combinations are R1 and R3, R1 and R4, R3 and R4, R1 and R3 and R4.
  • R2 is methyl
  • R3 is methoxypropoxy
  • Z is C-H, wherein all hydrogen atoms of R2, R3 or R2 and R3 are replaced by deuterium atoms.
  • R1 is methoxy
  • R2 and R4 are methyl and R3 is methoxy
  • R1 is hydrogen, methoxy or difluoromethoxy
  • R2 is methyl or methoxy
  • R3 is methoxy, 2,2,2-trifluoroethoxy or methoxypropoxy
  • R4 is hydrogen or methyl and wherein all hydrogen atoms of R3 are replaced by deuterium atoms.
  • R1 is methoxy, R2 is methyl, R3 is methoxy, R4 is methyl or wherein R1 is hydrogen, R2 is methyl, R3 is 2,2,2-trifluoroethoxy or methoxypropoxy, R4 is hydrogen or wherein R is difluoromethoxy, R2 is methoxy, R3 is methoxy, R4 is hydrogen and wherein all hydrogen atoms of R3 are replaced by deuterium atoms.
  • the term "hydrogen atom replaced by a deuterium atom” has to be understood as defining a degree of deuteration of at least 80 % for the bulk material, where all these correspondingly mentioned hydrogen atoms are replaced by deuterium atoms.
  • the substitu- ent R2 or R3 refers to a methoxy group having all three "hydrogen atoms replaced by a deuterium atoms” it is to be understood according to the above definition that at least 80% of all the R2 or R3 methoxy groups in the bulk material are -OCD 3 .
  • the remaining part up to 100% includes -OCHD 2 , - OCH 2 D Or-OCH 3 .
  • the compounds according to the invention are chiral compounds.
  • the invention thus relates to the racemates as well as to the enantiomers and mixtures thereof in any desired ratio.
  • a preferred subject matter of the inventions are the enantiomers of the compounds of formula 1 , preferably the enantiomers being substantially free of the respective other enantiomer with opposite configuration.
  • Particularly preferred compounds with (S)-configuration within the scope of the invention are the compounds (S)-5-methoxy-2-[(4-trideuteriomethoxy-3,5-dimethyl-2-pyridinyl)methylsulphinyl]-1 H- benzimidazole, (S)-5-trideuteriomethoxy-2-[(4-trideuteriomethoxy-3,5-dimethyl-2- pyridinyl)methylsulphinyl]-1 H-benzimidazole, (S)-5-methoxy-2-[(4-dideuteriomethoxy-3,5-dimethyl-2- pyridinyl)methylsulphinyl]-1 H-benzimidazole, (S)-5-trideuteriomethoxy-2-[(4-dideuteriomethoxy-3,5- dimethyl-2-pyridinyl)methylsulphinyl]-1 H-benzimidazole, (S)-5-trideuteriomethoxy-2-[(
  • a particularly preferred compound with (R)-configuration within the scope of the invention is the compound (R)-5-difluoromethoxy-2-[(3-methoxy-4-trideuteriomethoxy-2-pyridylmethyl)sulphinyl]-1 H- benzimidazole, (R)-5-difluoromethoxy-2-[(3-methoxy-4-dideuteromethoxy-2-pyridylmethyl)sulphinyl]- 1 H-benzimidazole and the solvates, preferably hydrates of these compounds, the salts of these compounds and the solvates, preferably hydrates of the salts of these compounds.
  • the separation of the compounds of formula 1 into the enantiomers can be accomplished according to various processes, for example as described in international patent application WO92/08716 or by column chromatography.
  • the compounds of formulae 1a and 1b can be obtained by chiral oxidation of the sulphides as described in international patent applications WO96/02535 or WO 2004/052881.
  • the salts of the compounds of formulae 1 , 1a and 1 b are prepared by processes known per se by reacting the compounds of formulae 1 , 1a, and 1 b, which can be regarded as weak acids, with suitable bases, for example with alkali metal hydroxides or alkoxides, such as sodium hydroxide or sodium methoxide, or with alkaline earth metal alkoxides, such as magnesium methoxide.
  • suitable bases for example with alkali metal hydroxides or alkoxides, such as sodium hydroxide or sodium methoxide, or with alkaline earth metal alkoxides, such as magnesium methoxide.
  • the magnesium salts of the compounds of formulae 1 , 1a and 1 b which are - besides the sodium salts - the preferred salts, are prepared in a manner known per se by reacting compounds of formulae 1 , 1a and 1 b with a magnesium base, for example a magnesium alkoxide, or from a readily soluble salt of a compound of formulae 1 , 1a and 1 b (for example of a sodium salt) using a magnesium salt in water or in mixtures of water with polar organic solvents (for example alcohols, preferably methanol, ethanol or isopropanol, or ketones, preferably acetone).
  • a magnesium base for example a magnesium alkoxide
  • a readily soluble salt of a compound of formulae 1 , 1a and 1 b for example of a sodium salt
  • polar organic solvents for example alcohols, preferably methanol, ethanol or isopropanol, or ketones, preferably acetone.
  • substantially free in the context of the invention means that the compounds with (S)-configuration and/or their salts, solvates or solvates of salts contain less than 10 % by weight of compounds with (R)-configuration and/or their salts, solvates or solvates of salts.
  • substantially free means that compounds with (S)-configuration and/or their salts, solvates or solvates of salts contain less than 5 % by weight of compounds with (R)-configuration and/or their salts, solvates or solvates of salts.
  • substantially free means that compounds with (S)-configuration and/or their salts, solvates or solvates of salts contain less than 2 % by weight of compounds with (R)-configuration and/or their salts, solvates or solvates of salts. In the most preferred embodiment, “substantially free” means that compounds with (S)-configuration and/or their salts, solvates or solvates of salts contain less than 1 % by weight of compounds with (R)-configuration and/or their salts, solvates or solvates of salts.
  • substantially free in the context of the invention means that the compounds with (R)-configuration and/or their salts, solvates or solvates of salts contain less than 10 % by weight of compounds with (S)-configuration and/or their salts, solvates or solvates of salts.
  • substantially free means that compounds with (R)-configuration and/or their salts, solvates or solvates of salts contain less than 5 % by weight of compounds with (S)-configuration and/or their salts, solvates or solvates of salts.
  • substantially free means that compounds with (R)-configuration and/or their salts, solvates or solvates of salts contain less than 2 % by weight of compounds with (S)-configuration and/or their salts, solvates or solvates of salts. In the most preferred embodiment, “substantially free” means that compounds with (R)-configuration and/or their salts, solvates or solvates of salts contain less than 1 % by weight of compounds with (S)-configuration and/or their salts, solvates or solvates of salts.
  • R1, R2, R3, R4 and Z have the meanings as given above and wherein at least one of the hydrogen atoms of R1 , R2, R3, R4 or any combination of R1 , R2, R3 and R4 is replaced by a deuterium atom, and their salts, such as the hydrochloride, the sulfate, the phosphate or other salts with acids, and their solvates.
  • These compounds can be used for the manufacture of compounds of general formula 1 , 1a or 1 b.
  • the compounds of formula 2 are suitable especially as starting material for an oxidation reaction resulting in compounds according formulae 1 , 1 a or 1 b.
  • Another aspect of the invention are compounds of formula 3
  • R3 and R4 have the meanings as given above and wherein at least one of the hydrogen atoms of R2, R3 and/or R4 is replaced by a deuterium atom.
  • R2 is methyl or methoxy
  • R3 is methoxy, 2,2,2- trifluoroethoxy or methoxypropoxy
  • R4 is hydrogen or methyl and wherein at least one of the hydrogen atoms of R3 is replaced by deuterium atoms.
  • R2 is methyl, R3 is methoxy, R4 is methyl or R2 is methoxy, R3 is methoxy, R4 is hydrogen or R2 is methyl, R3 is 2,2,2-trifluoroethoxy or methoxypropoxy, R4 is hydrogen and wherein at least one of the hydrogen atoms of R3 is replaced by deuterium atoms.
  • R2 is methyl, R3 is methoxy, R4 is methyl or R2 is methoxy, R3 is methoxy, R4 is hydrogen or R2 is methyl, R3 is 2,2,2-trifluoroethoxy or methoxypropoxy, R4 is hydrogen and wherein at least two or all of the hydrogen atoms of R3 are replaced by deuterium atoms.
  • halogen is iodine, bromine, chlorine and fluorine.
  • X is chlorine.
  • An activated derivative of an alcohol is an alkylsulfonate group, for example mesylate or an aryl- sulfonate group, for example tosylate or besylate, or a perfluoroalkanesulfonate group, for example trifluormethanesulfonate.
  • X, R2 and R4 have the meanings as given above, R5 being chloro or nitro and wherein at least one of the hydrogen atoms of R2 and/or R4 is replaced by a deuterium atom.
  • R5 being chloro or nitro and wherein at least one of the hydrogen atoms of R2 and/or R4 is replaced by a deuterium atom.
  • Preferred are compounds of formula 3a wherein R2 is methyl or methoxy, R4 is hydrogen or methyl and wherein at least one of the hydrogen atoms of R2 and/or R4 is replaced by deuterium atoms.
  • R2 and R4 are methyl and wherein at least one of the hydrogen atoms of R2 and/or R4 is replaced by deuterium atoms.
  • the compounds of formula 3a can be used for the manufacture of compounds of formula 2a.
  • R1, R2, R5, R4 and Z have the meanings as given above and wherein at least one of the hydrogen atoms of R1 , R2, R4 or any combination of R1 , R2 and R4 is replaced by a deuterium atom.
  • the nitrogen atom of compound of formula 3a is first quatemised and then reacted with compounds of formula 4
  • R1 is 1-4C alkoxy
  • Z is C-H or N and wherein at least one of the hydrogen atoms of R1 is replaced by a deuterium atom.
  • R1 is methoxy.
  • reaction mixture is concentrated in vacuo (30 - 40 0 C) to about one third of the original volume and water (about 70 mL) is added.
  • the mixture is stirred for another 12 hours during which the pH is monitored.
  • the beige crystals are filtered off and washed with 10 mL of water.
  • the title compound is obtained in a yield of about 1.6 g (75 % of theory) and an optical purity of > 98 %.
  • reaction mixture was cooled to 20-30 0 C and diluted with water (21 L) before the pH was adjusted to 7-8 with 20% aqueous HCI ( ⁇ 7.5 L). Precipitation of product was achieved by addition of water (75 h) over about 4 h. The resulting slurry was heated to 35-45 0 C for 1.5 h before being chilled to 10-15 0 C.
  • the resulting slightly turbid aqueous solution was washed twice with MIBK (12 L each) and cleared by Hyflo treatment (0.40 kg), before the pH was adjusted to 9.0-9.5 by addition of 10% aqueous acetic acid ( ⁇ 8 L) at 40-45 0 C. Once product started to crystallize, further 10% acetic acid was added so as to continuously maintain a pH of 9.0-9.5.
  • the organic layer was extracted with another 400 mL of water at pH 13. After treatment with Hyflo Super CeI (5.0 g), the pH of the combined aqueous phase is adjusted to about 9 by addition of 10% aqueous acetic acid at 40 - 45 0 C. Once precipitation of product had set in, the mixture was stirred for another 12 h with eventual readjustment of the pH. Crude product (160 g, 75% yield) with an optical purity of > 98 % was obtained by filtration including an aqueous rinse (200 mL).
  • zirconium (IV) n-propoxide (0.40 mL, 70 % in n-propanol, 0.90 mmol) was added and stirring at 40 0 C was continued for one more hour.
  • N-ethyldiisopropylamine (0.11 mL, 0.63 mmol) and cumene hydroperoxide (1.52 mL, ⁇ 80% strength, 8.55 mmol) were added.
  • the clear reaction mixture was diluted with methyl isobutyl ketone (8.5 mL) and quenched with sodium thiosulphate (0.11 g) in saturated sodium bicarbonate solution (15 mL).
  • the organic layer was washed twice with saturated sodium bicarbonate solution (7.5 mL each).
  • the organic layer was extracted twice more with water (7.5 mL) at pH 12.5-13 (through addition of prerequisite amount of 40% aqueous NaOH).
  • the combined organic phase was washed with dichloromethane (15 mL). Then, the pH was adjusted to about 10 with potassium dihydrogen phosphate and the aqueous solution was extracted with dichloromethane (once 40 mL and twice 10 mL).
  • 4-chloro-2-chloromethyl-3-methylpyridinium chloride could be reacted with 1 H- benzimidazole-2-thiol according to the procedure described under Example 7 to give 2-[(4-chloro-3- methyl-2-pyridinyl)methylthio]-1 /-/-benzimidazole.
  • 4-chloro-2-chloromethyl-3,5-dimethylpyridinium chloride could be reacted with 5- methoxy-1/-/-imidazo[4,5-b]pyridine-2-thiol according to the procedure described under Example 33 to give 5-methoxy-2-[(4-chloro-3,5-dimethyl-2-pyridinyl)methylthio]-1 /-/-imidazo[4,5-b]pyridine.
  • the invention also embraces the use of the compounds according to the invention for preparing pharmaceutical compositions used for the treatment and/or prophylaxis of the abovementioned diseases.
  • the invention also provides pharmaceutical compositions comprising the compounds according to the invention.
  • the invention provides pharmaceutical compositions for oral use in solid form, containing the compounds of formulae 1 , 1 a or 1 b in the form of their salts, in particular in the form of a sodium or magnesium salt, and/or in the form of a hydrate of such salt.
  • the pharmaceutical compositions are prepared by processes known per se which are familiar to the person skilled in the art.
  • auxiliaries or carriers suitable for the desired pharmaceutical formulations are known to the person skilled in the art.
  • solvents for example, antioxidants, dispersants, emulsifiers, antifoams, flavour-masking agents, preservatives, solubilizers, colorants or, in particular, permeation promoters and complex formers (for example cyclodextrins).
  • the compounds according to the invention can be administered orally, parenterally or percutaneously.
  • a further aspect of the invention is the use of the compounds according to the invention for treating gastrointestinal disorders in patients who are slow metabolizers.
  • a further aspect of the invention is the use of the compounds according to the invention hereof for treating gastrointestinal disorders in patients who have a risk of drug interactions.
  • a further aspect of the invention is the use of the compounds according to the invention for treating gastrointestinal disorders in patients who need an inhibition of acid secretion for an extended period of time.
  • a further aspect of the invention is a pharmaceutical composition for treating gastrointestinal disorders for use in patients who need an inhibition of acid secretion for an extended period of time, comprising one or more compound according to the invention together with one or more customary auxiliaries, where the single dose comprises from about 2 to about 60 mg of free compound.
  • a further aspect of the invention is a pharmaceutical composition for treating gastrointestinal disorders for use in patients who need an inhibition of acid secretion for an extended period of time, comprising one or more compound according to the invention together with one or more customary auxiliaries, where the single dose comprises from about 4 to about 40 mg of free compound.
  • a further aspect of the invention is a pharmaceutical composition for treating gastrointestinal disorders for use in patients who are slow metabolizers, comprising in an oral solid application form one or more salt according to the invention or a hydrate thereof together with one or more customary auxiliaries, where the single dose comprises from about 4 to about 40 mg of free compound.
  • a further aspect of the invention is a pharmaceutical composition for treating gastrointestinal disorders for use in patients who have a risk for drug interactions, comprising in an oral solid application form one or more salt according to the invention or a hydrate thereof together with one or more customary auxiliaries, where the single dose comprises from about 4 to about 40 mg of free compound.
  • a further aspect of the invention is a pharmaceutical composition for treating gastrointestinal disorders for use in patients who need an inhibition of acid secretion for an extended period of time, comprising in an oral solid application form one or more salt according to the invention or a hydrate thereof together with one or more customary auxiliaries, where the single dose comprises from about 4 to about 40 mg of free compound.
  • the pharmaceutical preparations may also comprise one or more pharmacologically active ingredients from other groups of pharmaceutical compositions.
  • pharmacologically active ingredients from other groups of pharmaceutical compositions.
  • examples that may be mentioned include tranquilizers (for example from the group of the benzodiazepines, e. g., diazepam), spasmolytic drugs (e. g., bietamiverine or camylofine), anticholinergic drugs (e. g., oxyphencyclimine or phencarbamide), local anesthetics (e. g., tetracaine or procaine), and optionally also enzymes, vitamins or amino acids.
  • tranquilizers for example from the group of the benzodiazepines, e. g., diazepam
  • spasmolytic drugs e. g., bietamiverine or camylofine
  • anticholinergic drugs e. g., oxyphencyclimine or phencarbamide
  • NSAIDs such as, for example, etofenamate, diclofenac, indometacin, ibuprofen or piroxicam
  • TLOSR transient lower esophageal sphincter relaxation
  • antibacterial substances such as, for example, cephalosporins, tetracyclins, penicillins, mac- rolides, nitroimidazoles or else bismuth salt
  • Antibacterial combination partners that may be mentioned include, for example, mezlocillin, ampicillin, amoxicillin, cefalothin, cefoxitin, cefotaxim, imipenem, gentamycin, amicacin, erythromycin, ciprofloxacin, metronidazole, clarithromycin, azithromycin and combinations thereof (e.g., clarithromycin + metronidazole or amoxicillin + clarithromycin).
  • the compounds according to this invention may be administered in combination therapy separately, sequentially, simultaneously or chronologically staggered (such as e.g. as combined unit dosage forms, as separate unit dosage forms, as adjacent discrete unit dosage forms, as fixed or non-fixed combinations, as kit-of-parts or as admixtures) with one or more standard therapeutics as those mentioned above.
  • combination may be present as a fixed combination, a non-fixed combination or a kit-of-parts.
  • a “fixed combination” is defined as a combination wherein a first active ingredient and a second active ingredient are present together in one unit dosage or in a single entity.
  • a “fixed combination” is a pharmaceutical composition wherein the said first active ingredient and the said second active ingredient are present in admixture of simultaneous administration, such as in a formulation.
  • Another example of a "fixed combination” is a pharmaceutical composition wherein the said first active ingredient and the said second active ingredient are present in one unit without being in admixture.
  • kits-of-parts is defined as a combination wherein the said first active ingredient and the said second active ingredient are present in more than one unit.
  • a “kit-of-parts” is a combination the said first active ingredient and the said second active ingredient are present separately.
  • the components of the kit-of-parts may be administered separately, sequentially, simultaneously or chronologically staggered.
  • Pantoprazole or examples 1 or 2 (10 ⁇ M each) were incubated with liver microsomes (source: all from GenTest except Mini Pig from TEBU ),incubation in 1 mg/ml protein, 100 mM Tris-HCI, pH 7.4, 1 mM NADPH 2 ). Reaction was terminated after 90 minutes by liquid nitrogen, the parent compound was detected by HPLC (10 mM KH 2 PO 4 , pH 7.4, acetonitril gradient 20-44 %).
  • CYP cytochrome P450
  • CYP2C19 and CYP3A4 were found to contribute to the oxidative metabolism of omeprazole, pantopra- zole and their deuterated analogues. All other cytochrome P450 isoenzymes (CYP1 A2, CYP2C8, CYP2C9, CYP2D6, CYP3A5) did not contribute to the metabolism of any of the compounds investigated above the lower limit of assay resolution.
  • the 5-(difluoromethoxy)-2-[[(3-methoxy-4-sulfate-2-pyridyl)-methyl]sulfinyl]-1 H- benzimidazole (M2) formation rate was determined at nine different compound concentrations (0, 0.5, 1.0, 2.5, 5.0, 10.0, 25.0, 50.0 and 100 ⁇ Mol/L) incubated in duplicate for 60 min at 37° C. 5-hydroxy- omeprazole was quantified using LC-MS/MS.
  • Racemic, (R), and (S)-analogues (examples 19, 27and 28 deuterated in the 4-methoxy-pyridyl position exhibited formation rates that were at least 2.5-fold reduced compared to their non-deuterated counterparts ( Figure 2B).
  • the intrinsic clearances of racemic, (R), and (S)-analogues deuterated in the 4-methoxy-pyridyl position (examples 19, 27 and 28) were at least 4.7-fold reduced compared to their non-deuterated counterparts (Table 2).
  • the stereospecific differences in M2 formation rates observed for the [ 1 H] pantoprazole analogues were less pronounced for analogues deuterated in the 4-methoxy-pyridyl position ( Figure 2B).
  • Table 2 Intrinsic clearance (Cl ⁇ nt )) in pooled human hepatocytes obtained upon incubation with pantoprazole and compounds according to the invention.

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  • Pyridine Compounds (AREA)
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EP06764258A 2005-07-26 2006-07-26 Isotopensubstituierte protonenpumpenhemmer Withdrawn EP1910293A1 (de)

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EP1934201A1 (de) * 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterierte hemmer von gastrischer h+, k+-atpase mit verstärkten therapeutischen eigenschaften
US20080255200A1 (en) * 2007-04-11 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
WO2008127640A2 (en) * 2007-04-11 2008-10-23 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
CA2789298A1 (en) 2010-02-12 2011-08-18 Esteve Quimica, S.A. Preparation process of the sodium salt of esomeprazole
CN104530003A (zh) * 2014-06-10 2015-04-22 广东东阳光药业有限公司 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法

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ES2293638T3 (es) * 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
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CA2615670C (en) 2015-01-20
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CN102134232B (zh) 2012-11-21
CN102134232A (zh) 2011-07-27
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HK1160126A1 (en) 2012-08-10
KR20080037676A (ko) 2008-04-30
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WO2007012650A1 (en) 2007-02-01
HK1125098A1 (en) 2009-07-31
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AR054584A1 (es) 2007-06-27
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EA016814B1 (ru) 2012-07-30
TWI394750B (zh) 2013-05-01
MX2008000901A (es) 2008-03-26
CA2615670A1 (en) 2007-02-01
BRPI0614039A2 (pt) 2011-03-09
EA200800203A1 (ru) 2008-08-29
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JP2009502871A (ja) 2009-01-29

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