JP5420848B2 - Whitening agent and skin external preparation for whitening - Google Patents

Description

  The present invention relates to a novel whitening agent and a skin external preparation for whitening.

Phospholipids such as soybean phospholipid are widely used as a base for external preparations for skin such as cosmetics. However, the use of a glycerol phosphate derivative obtained by deacylating this has not been well known. Patent Documents 1 and 2 propose use of glycerol phosphate or a derivative thereof as an external preparation for skin. However, these patent documents do not describe that these agents exhibit a whitening action alone.
Japanese Patent Laid-Open No. 64-16890 JP 7-506348

  An object of the present invention is to provide a novel whitening agent and a skin external preparation for whitening.

In order to solve the above-mentioned problems, the present invention provides a whitening agent containing at least one glycerol phosphate derivative as an active ingredient, and a whitening skin external preparation containing this as an active ingredient.
Among the glycerol phosphate derivatives, glycerol phosphoryl ethanolamine and glycerol phosphoryl inositol are preferable. Also, the glycerol derivatives, preferably glycerol phosphorylethanolamine and glycerol phosphoryl inositol are preferably deacylated products of soybean phospholipid.

  ADVANTAGE OF THE INVENTION According to this invention, the novel whitening agent which shows a favorable whitening effect | action, and the skin external preparation which shows the favorable whitening effect brought about by this whitening agent can be provided.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after.
The present invention relates to a whitening agent containing at least one glycerol phosphate derivative as an active ingredient. The whitening agent of the present invention may contain a kind of glycerol phosphate derivative as an active ingredient, or may contain two or more different glycerol phosphate derivatives as an active ingredient. In the present specification, the “glycerol phosphate derivative” refers to a compound in which any one of the hydrogen atoms of three hydroxyl groups of glycerin is substituted with a phosphate derivative. Examples thereof include glycerol phosphorylcholine (hereinafter sometimes referred to as “GPC”), glycerol phosphorylethanolamine (hereinafter sometimes referred to as “GPE”), and glycerol phosphorylinositol (hereinafter referred to as “GPI”). Is included). GPC, GPE and GPI are each a compound represented by the following general formula.

These compounds contain acyl groups in the molecule of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI), which are components of soybean phospholipid and egg yolk phospholipid. Each has a deacylated structure.
The method for synthesizing these compounds used in the present invention is not particularly limited. Any of a compound obtained by deacylating a phospholipid and a compound obtained by chemical synthesis without passing through the deacylation step can be used.

  For example, egg yolk phospholipid and soybean phospholipid contain the above PC, PE, and PI. Therefore, the whitening agent of the present invention can be prepared by deacylating egg yolk phospholipid and soybean phospholipid. In addition, after egg yolk phospholipid or soybean phospholipid is deacylated, GPC, GPE and GPI are isolated by chromatogram or the like, and the isolated compounds can be used. In addition, chemically synthesized GPC, GPE and GPI can also be used for the whitening agent of the present invention. Since GPC is commercially available as a reagent (for example, manufactured by Wako Pure Chemical Industries, Ltd.), the whitening agent of the present invention can be prepared by mixing the reagent as it is or with GPE or GPI. GPE or GPI is a reagent in which a fatty acid and a corresponding phosphoric acid derivative are bound to glycerol (for example, dipalmitoyl phosphatidylethanolamine (manufactured by Wako Pure Chemical Industries) and dipalmitoyl phosphatidylinositol sodium salt (manufactured by Wako Pure Chemical Industries)) Are commercially available, and can be synthesized by deacylating them.

  Among the glycerol phosphate derivatives, GPE and GPI are preferable because of their high whitening effect. That is, the whitening agent of the present invention preferably contains at least one of GPE and GPI as an active ingredient. More specifically, it is preferable that the whitening agent of the present invention contains GPE and / or GPI at a mass ratio of 30% or more. Soy phospholipid contains about 14% by mass and 17% by mass of PE and PI, respectively. Therefore, since the whitening agent prepared by deacylating soybean phospholipid contains about 31% of GPE and GPI as a total amount, it is considered that a high whitening effect is exhibited.

  The present invention also relates to a skin external preparation containing the whitening agent of the present invention, that is, a whitening agent containing at least one selected from glycerol phosphate derivatives as an active ingredient. The external preparation for skin of the present invention exhibits an excellent whitening effect due to the whitening action of the glycerol phosphate derivative. The content of the whitening agent in the external preparation for skin of the present invention is preferably 0.0001 to 20% by mass (hereinafter simply referred to as “%”), more preferably 0.001 to 10%. If it exists in this range, the said extract can be mix | blended stably and the high whitening effect can be exhibited.

  The external preparation for skin of the present invention can be prepared by blending the above-mentioned whitening agent with various forms of bases according to a conventional method. Furthermore, by adding the whitening agent in combination with one or more of other medicinal agents, a skin external preparation having a higher whitening effect or exhibiting other medicinal effects along with the whitening effect can be prepared. Examples of other medicinal agents include, but are not limited to, other whitening agents, UV protection agents, antibacterial agents, anti-inflammatory agents, cell activators, active oxygen scavengers, and moisturizers. Absent.

  Examples of other whitening agents include ascorbic acid or derivatives thereof, arbutin, ellagic acid, linoleic acid, vitamin E and derivatives thereof, glycyrrhizic acid and derivatives thereof, tranexamic acid, placenta extract, chamomile extract, licorice extract, Ages extract, Ogon extract, seaweed extract, cucumber extract, quette extract, gokahi extract, rice bran extract, wheat germ extract, saishin extract, hawthorn extract, sunpens extract, shirayuri extract, peonies Extracts, Sempukuka extract, soybean extract, tea extract, molasses extract, juniper extract, grape extract, hop extract, micaika extract, mokka extract, yukinoshita extract and the like are included.

  Examples of the UV protection agent include paramethoxycinnamate-2-ethylhexyl, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5 sodium sulfate, 4-t-butyl-4′- Examples thereof include methoxydibenzoylmethane, 2-phenyl-benzimidazole-5-sulfuric acid, titanium oxide, and zinc oxide.

  Examples of the antibacterial agent include benzoic acid, sodium benzoate, p-hydroxybenzoate ester, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, and the like.

  Anti-inflammatory agents include, for example, sulfur and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, artea extract, ashitaba extract, arnica extract, ginseng extract, nettle extract, buckwheat extract, hypericum Examples include extracts, chamomile extracts, goldfish extract, watercress extract, comfrey extract, salvia extract, sicon extract, perilla extract, birch extract, gentian extract and the like.

  Examples of cell activators include caffeine, chicken crown extract, shell extract, shell extract, royal jelly, silk protein and its degradation products or derivatives thereof, lactoferrin or degradation products thereof, chondroitin sulfate, hyaluronic acid, etc. Mucopolysaccharides or their salts, collagen, yeast extract, lactic acid bacteria extract, bifidobacteria extract, fermentation metabolic extract, ginkgo biloba extract, barley extract, assembly extract, peanut extract, carrot extract, rosemary Extracts, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, succinic acid and the like are included.

  The active oxygen scavenger has an action such as suppression of lipid peroxide production. For example, superoxide dismutase, mannitol, quercetin, catechin and derivatives thereof, rutin and derivatives thereof, button pi extract, yashajitsu extract, melissa extract , Lanahan fruit extract, retinol and its derivatives, vitamin A such as carotenoid, thiamine and its derivative, riboflavin and its derivative, pyridoxine and its derivative, vitamin B such as nicotinic acid and its derivative, tocopherol and its derivative, etc. Vitamin E, dibutylhydroxytoluene, butylhydroxyanisole, etc. are mentioned.

  Examples of the humectant include proteins such as elastin and keratin or derivatives thereof, hydrolysates and salts thereof, amino acids such as glycine, serine, aspartic acid, glutamic acid, arginine and theanine and derivatives thereof, sorbitol, erythritol, Trehalose, inositol, glucose, sucrose and derivatives thereof, dextrin and derivatives thereof, saccharides such as honey, D-panthenol and derivatives thereof, urea, phospholipid, ceramide, auren extract, ginger extract, diautum extract, sensyu extract Product, mallow extract, gypsophila extract, dokudami extract, hamamelis extract, bodaige extract, maronier extract, quince extract and the like.

  Moreover, arbitrary components other than the whitening agent of this invention can be mix | blended with the skin external preparation of this invention. Examples of such components include, but are not limited to, physiologically active substances such as amino acids, lipids, sugars, hormones, enzymes, and nucleic acids. In addition, components that are usually used in the production of cosmetics, quasi-drugs, skin external preparations and the like, for example, water (purified water, hot spring water, deep water, etc.), oil agents, Surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, inclusion compound, fragrance, deodorant, salt, pH adjuster, refreshing agent, plant / animal -Extracts derived from microorganisms, blood circulation promoters, astringents, antiseborrheic agents, chelating agents, keratolytic agents, enzymes, hormones, other vitamins and the like can be used as necessary.

  The external preparation for skin of the present invention has various forms such as powders such as powder and powder foundation; solids such as soap and lipstick; emulsions such as cream, emulsion and cream foundation; It is preferable that it is a cosmetic composition. However, it is not limited to these.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the scope of the present invention is not limited to the following examples.
[Example 1: Preparation of whitening agent]
A reagent manufactured by Wako Pure Chemical Industries was used as GPC.
About GPE and GPI, it manufactured by carrying out the deacylation process of the dipalmitoyl phosphadyl ethanolamine (made by Wako Purechemical) and the phosphatidylinositol sodium salt (made by Wako Purechemical), respectively. Deacylation proceeded by the action of metal sodium or sodium alcoholate in alcohol. In addition, a product obtained by subjecting soybean phospholipid to a deacylation process (hereinafter sometimes referred to as GSP) by a similar method was also produced.

[Example 2: Evaluation of whitening effect]
B16 melanoma cultured cells derived from mice were used to evaluate the whitening effect of GPE and GPI. Specifically, an appropriate amount of 10% FBS-containing MEM medium was taken in a 6-well plate, seeded with B16 melanoma cells, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, the compound obtained in Production Example 1 was dissolved in water-containing ethanol (water / ethanol = 50/50 (volume ratio)) and added. On day 5 of the culture, the medium was changed, and the sample preparation solution was added again. On the next day, the medium was removed and the cells were collected after washing with phosphate buffer on one plate, and the degree of whiteness of the cultured B16 melanoma cells was evaluated according to the following criteria. As a control, a sample to which no specimen was added was prepared. Samples were prepared to have a GPE and GPI concentration of 10%, and 30, 50, and 100 μL were added to 2 mL of the medium.
(Criteria)
++: Clearly white relative to the control.
+: White with respect to the control.
-: The same black color as the control.
The results are shown in the table below.

  From the results shown in the above table, it can be understood that GPE and GPI, which are glycerol phosphate derivatives, show a high whitening effect. In addition, although the test was done similarly about GPC, although the whitening effect was recognized, the whitening effect was low compared with GPE and GPI.

[Example 3: lotion]
A lotion was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (11) are mixed and dissolved.
B. The following components (12) to (18) are mixed and dissolved.
C. B was added to A and mixed uniformly to obtain a skin lotion.
(Ingredient) (%)
(1) Glycerol 3.0
(2) 1,3-butylene glycol 2.0
(3) Propylene glycol 4.0
(4) Oleyl alcohol 0.1
(5) Polyoxyethylene monolaurate (20E.O.)
Sorbitan 1.5
(6) Polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalane 0.5
(8) Ethyl alcohol 20.0
(9) Methyl paraoxybenzoate 0.1
(10) dl-α-tocopherol acetate * 1 0.5
(11) Perfume appropriate amount (12) Sakuhakuhi extract * 2 0.5
(13) Apple extract * 3 0.5
(14) Sodium dl-pyrrolidonecarboxylate * 4 0.2
(15) Locust bean gum 1.0
(16) GPI * 5 2.0
(17) GPE * 6 2.0
(18) Purified water remaining * 1 Eisai * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical * 4 Ajinomoto * 5 Prepared in Example 1 * 6 Prepared in Example 1

  The prepared lotion was a lotion that had a fresh and refreshing feeling of use, improved or prevented stains and freckles, and made beautiful skin with transparency.

[Example 4: Cream]
A cream was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) are heated and mixed and maintained at 70 ° C.
B. The following components (11) to (20) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (21) was added and mixed to obtain a cream.
(Ingredient) (%)
(1) Squalane 20.0
(2) Beeswax 5.0
(3) Jojoba oil 5.0
(4) Glyceryl monostearate 2.0
(5) Polyoxyethylene monostearate (20E.O.)
Sorbitan 2.0
(6) Sorbitan monostearate 2.0
(7) Phytosterol * 1 0.5
(8) Candelilla wax 1.0
(9) Glycerin 5.0
(10) Methyl paraoxybenzoate 0.1
(11) Lily extract * 2 1.0
(12) Carrot extract * 3 1.0
(13) Ginkgo biloba extract * 4 1.0
(14) Ogon extract * 5 1.0
(15) Clara extract * 6 1.0
(16) Hydrolyzed rice extract * 7 1.0
(17) Licorice extract * 8 1.0
(18) Toki extract * 9 1.0
(19) GPE * 10 2.0
(20) Purified water Remaining amount (21) Fragrance Appropriate amount * 1 Eisai * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical * 4 Joban Plant Chemistry Laboratories * 5 Maruzen Pharmaceutical * 6 Maruzen Pharmaceutical * 7 Made by Technol * 8 Made by Maruzen Pharmaceutical * 9 Made by Nippon Powder Co., Ltd. * 10 Prepared in Example 1

  The prepared cream had a smooth and rich use feeling, a fresh and refreshing use feeling, and was able to improve or prevent spots and freckles, and to make the skin beautiful and transparent. .

[Example 5: Cleansing cream]
A cleansing cream was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) are heated and mixed and maintained at 70 ° C.
B. The following components (10) to (14) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (15) was added and mixed to obtain a cleansing cream.
(Ingredient) (%)
(1) Paraffin wax 10.0
(2) Beeswax 3.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) Sorbitan sesquioleate 4.2
(6) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.8
(7) Hydrogenated soybean phospholipid 0.5
(8) Medu home oil * 1 1.0
(9) Methyl paraoxybenzoate 0.1
(10) Quince seed extract * 2 1.0
(11) Soybean extract * 3 1.0
(12) Mallow extract * 4 1.0
(13) GPI * 5 0.5
(14) Purified water Remaining amount (15) Perfume appropriate amount * 1 Made by Nippon Surfactant * 2 Made by Koei Kogyo * 3 Made by Maruzen Pharmaceutical * 4 Made by Maruzen Pharmaceutical * 5 Prepared in Example 1

  The prepared cleansing cream has a light and smooth feeling of use, is well-familiar with makeup stains, is excellent in removing stains, has a fresh and refreshing feel, improves or prevents spots and freckles, and has a transparent feeling It was a cleansing cream that can give beautiful skin.

[Example 6: Latex]
An emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (14) to (23) are heated and mixed and maintained at 70 ° C.
B. The following components (1) to (13) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following components (24), (25), and (26) were added and mixed to obtain an emulsion.
(Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Plant squalane * 1 0.2
(9) Glyceryl tri-2-ethylhexanoate 2.0
(10) Dimethylpolysiloxane 1.0
(11) Hydrogenated soybean phospholipid 0.1
(12) nicotinic acid dl-α-tocopherol * 2 0.05
(13) Methyl paraoxybenzoate 0.1
(14) Carboxyvinyl polymer 0.1
(15) Sodium hydroxide 0.05
(16) Glycerin 5.0
(17) 1,3-butylene glycol 7.0
(18) Purified water remaining amount (19) GPE * 3 0.8
(20) Yukinoshita extract * 4 2.0
(21) GSP * 5 0.8
(22) Sodium hyaluronate 1% aqueous solution * 6 5.0
(23) Acetylglutamic acid * 7 0.3
(24) Ethyl alcohol 5.0
(25) Porous silica 3.0
(26) Fragrance Appropriate amount * 1 Nikko Chemicals * 2 Eisai * 3 Prepared in Example 1 * 4 Maruzen Pharmaceutical * 5 Prepared in Example 1 * 6 Nikko Chemicals * 7 Kyowa Hakko

[Example 7: Latex]
An emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (13) to (22) are heated and mixed and maintained at 70 ° C.
B. The following components (1) to (12) are heated and mixed and maintained at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling C, the following components (23), (24), and (25) were added and mixed to obtain an emulsion.
(Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Rutin * 1 0.2
(12) Methyl paraoxybenzoate 0.1
(13) Carboxyvinyl polymer 0.1
(14) Sodium hydroxide 0.05
(15) Glycerin 5.0
(16) 1,3-butylene glycol 7.0
(17) GPE * 2 0.1
(18) Purified water remaining amount (19) Yeast extract * 3 0.5
(20) GPI * 4 0.1
(21) Peonies extract * 5 0.5
(22) Peach extract * 6 0.5
(23) Ethyl alcohol 5.0
(24) Porous silica 3.0
(25) Fragrance Appropriate amount * 1 Made by Sigma * 2 Made in Example 1 * 3 Made by BIO-DELL * 4 Made in Example 1 * 5 Made by Maruzen Pharmaceutical * 6 Made by Maruzen Pharmaceutical

  Examples 6 and 7 were emulsions that had a smooth and mild feeling of use, had a fresh and refreshing feeling, improved or prevented spots and freckles, and made clear and beautiful skin. .

[Example 8: Pack]
A pack was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (7) are mixed and heated to 70 ° C. to dissolve.
B. The following components (8) to (13) are mixed and dissolved.
C. The following components (14) to (16) are mixed and dissolved.
D. B was added to A, mixed and then cooled, and further C was mixed to obtain a pack.
(Ingredient) (%)
(1) Polyvinyl alcohol 13.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Medu home oil * 1 0.2
(5) Polyoxypropylene (10 PO)
Methyl glucoside 5.0
(6) Glycerin 5.0
(7) Purified water remaining amount (8) Tea extract * 2 1.0
(9) Hermanus extract * 3 1.0
(10) Anhydrous caffeine * 4 1.0
(11) GSP * 5 3.0
(12) Phosphoric acid-L-ascorbyl magnesium * 6 3.0
(13) Purified water 10.0
(14) Ethyl paraoxybenzoate 0.1
(15) Ethyl alcohol 13.0
(16) Fragrance Appropriate amount * 1 Made by Nippon Surfactant Co., Ltd. * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Maruzen Pharmaceutical Co., Ltd. * 4 Made by Pure Chemical Industries, Ltd. * 5 Prepared in Example 1 * 6 Made by Nikko Chemicals

  Example 8 has moderate refreshment and tension, and the skin after packing has a feeling of elasticity on the skin, has a fresh and refreshing feeling, improves or prevents spots and freckles, and is transparent. It was a pack that can make the skin feel beautiful.

[Example 9: Cream foundation]
A cream foundation was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (11) are heated and mixed and maintained at 70 ° C.
B. The following components (12) to (17) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling C, the following component (18) was added and mixed to obtain a cream foundation.
(Ingredient) (%)
(1) Sorbitan sesquioleate 3.0
(2) Self-emulsifying glyceryl monostearate 2.0
(3) Aluminum stearate 0.5
(4) Ceresin wax 5.0
(5) Squalane 10.0
(6) Liquid paraffin 15.0
(7) Vaseline 5.0
(8) Titanium oxide 8.0
(9) Talc 4.0
(10) Coloring pigment appropriate amount (11) Methyl paraoxybenzoate 0.05
(12) Propylene glycol 5.0
(13) Kinginga extract * 1 1.0
(14) Arnica extract * 2 1.0
(15) Maronnier extract * 3 1.0
(16) GPI * 4 2.0
(17) Purified water Remaining amount (18) Fragrance appropriate amount * 1 Nagaoka Fragrance Co., Ltd. * 2 Maruzen Pharmaceutical Co., Ltd. * 3 Koei Kogyo Co., Ltd. * 4 Prepared in Example 1

[Example 10: Liquid foundation]
A liquid foundation was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) are mixed and dissolved.
B. The following components (20) to (25) are added to A, mixed uniformly, and kept at 70 ° C.
C. The following components (10) to (19) are uniformly dissolved and maintained at 70 ° C.
D. B is added to C and emulsified.
E. After cooling D, the following component (26) was added and mixed to obtain a liquid foundation.
(Ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4′-methoxy dibenzoylmethane 2.0
(8) Retinol palmitate * 1 0.2
(9) Methyl paraoxybenzoate 0.1
(10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Oat extract * 2 5.0
(15) Purified water remaining amount (16) Mannitol * 3 0.1
(17) GPE * 4 0.05
(18) GPI * 5 0.05
(19) Licorice extract * 6 0.5
(20) Titanium oxide 6.0
(21) Fine particle titanium oxide 2.0
(22) Fine zinc oxide 5.0
(23) Mica 2.0
(24) Talc 4.0
(25) Color pigment 4.0
(26) Fragrance appropriate amount * 1 Nippon Roche * 2 Maruzen Pharmaceutical * 3 Sigma * 4 Prepared in Example 1 * 5 Prepared in Example 1 * 6 Maruzen Pharmaceutical

  Examples 9 and 10 have a smooth and smooth use feeling, a uniform and beautiful finish, a fresh and refreshing use feeling, improving or preventing spots and freckles, and beautiful skin with transparency It was a cream foundation and a liquid foundation.

[Example 11: Sunscreen emulsion]
Sunscreen emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) are mixed and maintained at 70 ° C.
B. The following components (11) to (15) are mixed and maintained at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling C, the following components (16) to (19) were added and mixed to obtain a sunscreen emulsion.
(Ingredient) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Methyl paraoxybenzoate 0.1
(7) Silicone-treated fine particle titanium oxide 10.0
(8) Silicone-treated fine particle zinc oxide 10.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Dipropylene glycol 3.0
(12) Ethyl alcohol 10.0
(13) GPE * 1 10.0
(14) Salt 0.2
(15) Purified water remaining amount (16) β-carotene * 2 0.01
(17) Chamomile extract * 3 1.0
(18) Cassis extract * 4 1.0
(19) Perfume Appropriate amount * 1 Prepared in Example 1 * 2 Sigma Co., Ltd. * 3 Maruzen Pharmaceutical Co., Ltd. * 4 Maruzen Pharmaceutical Co., Ltd.

  The prepared sunscreen emulsion has a smooth and non-sticky feeling, protects the skin from ultraviolet rays, has a fresh and refreshing feeling, improves or prevents spots and freckles, and has a beautiful and clear skin. It could be a sunscreen latex.

  ADVANTAGE OF THE INVENTION According to this invention, the novel whitening agent and the skin external preparation for whitening can be provided.

Claims (5)

A melanin production inhibitor containing glycerol phosphorylethanolamine or glycerol phosphorylinositol as an active ingredient. The melanin production inhibitor according to claim 1, comprising at least glycerol phosphorylethanolamine as an active ingredient. The melanin production inhibitor according to claim 1 or 2, comprising at least glycerol phosphorylinositol as an active ingredient. The melanin production inhibitor according to any one of claims 1 to 3, wherein the glycerol phosphorylethanolamine or glycerol phosphoryl inositol is a deacylated product of soybean phospholipid. Skin external preparation for inhibition of melanin production which comprises, as an active ingredient a melanin production inhibitor according to any one of claims 1 to 4.