JP5419892B2 - キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 - Google Patents
キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 Download PDFInfo
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- JP5419892B2 JP5419892B2 JP2010541062A JP2010541062A JP5419892B2 JP 5419892 B2 JP5419892 B2 JP 5419892B2 JP 2010541062 A JP2010541062 A JP 2010541062A JP 2010541062 A JP2010541062 A JP 2010541062A JP 5419892 B2 JP5419892 B2 JP 5419892B2
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- JP
- Japan
- Prior art keywords
- alkyl
- amino
- methylpiperazin
- quinazoline
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
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- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08100015.0 | 2008-01-02 | ||
| EP08100015A EP2077263A1 (en) | 2008-01-02 | 2008-01-02 | Quinazolines and related heterocyclic compounds and their therapeutic use |
| PCT/EP2009/050012 WO2009083608A1 (en) | 2008-01-02 | 2009-01-02 | Quinazolines and related heterocyclic compounds, and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508756A JP2011508756A (ja) | 2011-03-17 |
| JP2011508756A5 JP2011508756A5 (enExample) | 2013-09-05 |
| JP5419892B2 true JP5419892B2 (ja) | 2014-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2010541062A Expired - Fee Related JP5419892B2 (ja) | 2008-01-02 | 2009-01-02 | キナゾリンおよび関連する複素環式化合物、ならびにそれらの治療的使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8530486B2 (enExample) |
| EP (2) | EP2077263A1 (enExample) |
| JP (1) | JP5419892B2 (enExample) |
| AU (1) | AU2009203124B2 (enExample) |
| CA (1) | CA2711272A1 (enExample) |
| ES (1) | ES2562674T3 (enExample) |
| PL (1) | PL2238119T3 (enExample) |
| WO (1) | WO2009083608A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101987829A (zh) * | 2009-08-03 | 2011-03-23 | 上海泺安医药技术有限公司 | 一种2-(氨基)乙基甲基砜新盐及制备 |
| EP2270002A1 (en) | 2009-06-18 | 2011-01-05 | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders |
| WO2011114916A1 (ja) * | 2010-03-18 | 2011-09-22 | 森永乳業株式会社 | 貧血の予防又は治療用組成物 |
| TW201210597A (en) * | 2010-06-09 | 2012-03-16 | Gilead Sciences Inc | Inhibitors of hepatitis C virus |
| WO2013060881A1 (en) | 2011-10-27 | 2013-05-02 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Pyridopyrimidines and their therapeutic use |
| CN102649841B (zh) * | 2012-04-06 | 2013-09-04 | 东南大学 | 苯胺基喹唑啉为靶向配体的聚乙二醇修饰磷脂衍生物及制法 |
| US9688989B2 (en) | 2012-06-08 | 2017-06-27 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| CN103819414B (zh) * | 2014-02-27 | 2016-06-01 | 福建医科大学 | 一种在水相中催化制备喹唑酮化合物的方法 |
| CN106632091B (zh) * | 2015-10-29 | 2021-05-11 | 中国科学院上海药物研究所 | 喹唑啉化合物在调控神经干细胞增殖和分化中的应用 |
| CN107586267B (zh) * | 2016-11-01 | 2020-02-18 | 华东师范大学 | 一种牛磺酰胺盐酸盐(2-氨基乙基磺酰胺盐酸盐)的合成方法 |
| MA53372B1 (fr) | 2018-07-25 | 2022-10-31 | Faes Farma Sa | Pyridopyrimidinones comme inhibiteurs du récepteur h4 de l'histamine |
| JP2023084709A (ja) * | 2020-04-28 | 2023-06-20 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ヒスタミンｈ４受容体調節作用を有する新規二環化合物 |
| CN119930479A (zh) * | 2025-04-09 | 2025-05-06 | 安徽昊帆生物有限公司 | 牛磺酰胺盐酸盐的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2121031A1 (en) | 1971-04-29 | 1972-11-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Base-substd quinazolines - thrombocyte aggregation inhibitors |
| US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| CA2440438C (en) * | 2001-03-09 | 2011-05-03 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds |
| HRP20060126A2 (en) | 2003-09-30 | 2008-05-31 | Janssen Pharmaceutica N.V. | Benzoimidazole compounds |
| WO2005033088A1 (en) | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
| AU2005303893A1 (en) * | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
| US20060111416A1 (en) | 2004-11-24 | 2006-05-25 | Lane Charlotte A L | Octahydropyrrolo[3,4-C]pyrrole derivatives |
| AU2006290715A1 (en) | 2005-09-13 | 2007-03-22 | Palau Pharma, S.A. | 2-aminopyrimidine derivatives as modulators of the histamine H4 receptor activity |
| EP1767537A1 (en) | 2005-09-21 | 2007-03-28 | Cellzome (UK) Ltd. | Pyrimidine compounds for the treatment of inflammatory disorders |
| EP2044027A2 (en) | 2006-07-03 | 2009-04-08 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Fused bicyclic compounds interacting with the histamine h4 receptor |
| EP2209775A1 (en) | 2007-10-09 | 2010-07-28 | UCB Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
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2008
- 2008-01-02 EP EP08100015A patent/EP2077263A1/en not_active Ceased
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2009
- 2009-01-02 EP EP09700137.4A patent/EP2238119B1/en not_active Not-in-force
- 2009-01-02 CA CA2711272A patent/CA2711272A1/en not_active Abandoned
- 2009-01-02 AU AU2009203124A patent/AU2009203124B2/en not_active Ceased
- 2009-01-02 PL PL09700137T patent/PL2238119T3/pl unknown
- 2009-01-02 JP JP2010541062A patent/JP5419892B2/ja not_active Expired - Fee Related
- 2009-01-02 US US12/811,547 patent/US8530486B2/en not_active Expired - Fee Related
- 2009-01-02 WO PCT/EP2009/050012 patent/WO2009083608A1/en not_active Ceased
- 2009-01-02 ES ES09700137.4T patent/ES2562674T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100298322A1 (en) | 2010-11-25 |
| WO2009083608A1 (en) | 2009-07-09 |
| EP2238119A1 (en) | 2010-10-13 |
| EP2238119B1 (en) | 2015-11-25 |
| PL2238119T3 (pl) | 2016-05-31 |
| WO2009083608A9 (en) | 2009-09-24 |
| ES2562674T3 (es) | 2016-03-07 |
| AU2009203124B2 (en) | 2012-03-15 |
| US8530486B2 (en) | 2013-09-10 |
| JP2011508756A (ja) | 2011-03-17 |
| CA2711272A1 (en) | 2009-07-09 |
| AU2009203124A1 (en) | 2009-07-09 |
| EP2077263A1 (en) | 2009-07-08 |
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