CA2711272A1 - Quinazolines and related heterocyclic compounds, and their therapeutic use - Google Patents
Quinazolines and related heterocyclic compounds, and their therapeutic use Download PDFInfo
- Publication number
- CA2711272A1 CA2711272A1 CA2711272A CA2711272A CA2711272A1 CA 2711272 A1 CA2711272 A1 CA 2711272A1 CA 2711272 A CA2711272 A CA 2711272A CA 2711272 A CA2711272 A CA 2711272A CA 2711272 A1 CA2711272 A1 CA 2711272A1
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- CA
- Canada
- Prior art keywords
- alkyl
- compound according
- phenyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000003246 quinazolines Chemical class 0.000 title description 6
- 230000001225 therapeutic effect Effects 0.000 title description 5
- 150000002391 heterocyclic compounds Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 87
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 18
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 7
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 7
- 150000002148 esters Chemical class 0.000 claims abstract description 7
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 6
- 239000012453 solvate Substances 0.000 claims abstract description 5
- 125000004122 cyclic group Chemical group 0.000 claims abstract 2
- -1 hydrazino, hydroxylamino Chemical group 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08100015.0 | 2008-01-02 | ||
| EP08100015A EP2077263A1 (en) | 2008-01-02 | 2008-01-02 | Quinazolines and related heterocyclic compounds and their therapeutic use |
| PCT/EP2009/050012 WO2009083608A1 (en) | 2008-01-02 | 2009-01-02 | Quinazolines and related heterocyclic compounds, and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
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| CA2711272A1 true CA2711272A1 (en) | 2009-07-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2711272A Abandoned CA2711272A1 (en) | 2008-01-02 | 2009-01-02 | Quinazolines and related heterocyclic compounds, and their therapeutic use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8530486B2 (enExample) |
| EP (2) | EP2077263A1 (enExample) |
| JP (1) | JP5419892B2 (enExample) |
| AU (1) | AU2009203124B2 (enExample) |
| CA (1) | CA2711272A1 (enExample) |
| ES (1) | ES2562674T3 (enExample) |
| PL (1) | PL2238119T3 (enExample) |
| WO (1) | WO2009083608A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101987829A (zh) * | 2009-08-03 | 2011-03-23 | 上海泺安医药技术有限公司 | 一种2-(氨基)乙基甲基砜新盐及制备 |
| EP2270002A1 (en) | 2009-06-18 | 2011-01-05 | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders |
| WO2011114916A1 (ja) * | 2010-03-18 | 2011-09-22 | 森永乳業株式会社 | 貧血の予防又は治療用組成物 |
| TW201210597A (en) * | 2010-06-09 | 2012-03-16 | Gilead Sciences Inc | Inhibitors of hepatitis C virus |
| WO2013060881A1 (en) | 2011-10-27 | 2013-05-02 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Pyridopyrimidines and their therapeutic use |
| CN102649841B (zh) * | 2012-04-06 | 2013-09-04 | 东南大学 | 苯胺基喹唑啉为靶向配体的聚乙二醇修饰磷脂衍生物及制法 |
| US9688989B2 (en) | 2012-06-08 | 2017-06-27 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| CN103819414B (zh) * | 2014-02-27 | 2016-06-01 | 福建医科大学 | 一种在水相中催化制备喹唑酮化合物的方法 |
| CN106632091B (zh) * | 2015-10-29 | 2021-05-11 | 中国科学院上海药物研究所 | 喹唑啉化合物在调控神经干细胞增殖和分化中的应用 |
| CN107586267B (zh) * | 2016-11-01 | 2020-02-18 | 华东师范大学 | 一种牛磺酰胺盐酸盐(2-氨基乙基磺酰胺盐酸盐)的合成方法 |
| MX2021000966A (es) | 2018-07-25 | 2021-07-06 | Faes Farma Sa | Piridopirimidinas como inhibidores del receptor de histamina h4. |
| JP2023084709A (ja) * | 2020-04-28 | 2023-06-20 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ヒスタミンｈ４受容体調節作用を有する新規二環化合物 |
| CN119930479A (zh) * | 2025-04-09 | 2025-05-06 | 安徽昊帆生物有限公司 | 牛磺酰胺盐酸盐的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2121031A1 (en) | 1971-04-29 | 1972-11-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Base-substd quinazolines - thrombocyte aggregation inhibitors |
| US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| MXPA03008143A (es) | 2001-03-09 | 2005-08-16 | Johnson & Johnson | Compuestos heterociclicos. |
| CA2540638A1 (en) | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
| AR045955A1 (es) | 2003-09-30 | 2005-11-16 | Janssen Pharmaceutica Nv | Compuestos benzoimidazolicos |
| AU2005303893A1 (en) | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
| US20060111416A1 (en) | 2004-11-24 | 2006-05-25 | Lane Charlotte A L | Octahydropyrrolo[3,4-C]pyrrole derivatives |
| JP2009507896A (ja) | 2005-09-13 | 2009-02-26 | パラウ・フアルマ・ソシエダツド・アノニマ | ヒスタミンｈ４受容体活性の調節剤としての２−アミノピリミジン誘導体 |
| EP1767537A1 (en) * | 2005-09-21 | 2007-03-28 | Cellzome (UK) Ltd. | Pyrimidine compounds for the treatment of inflammatory disorders |
| EP2044027A2 (en) | 2006-07-03 | 2009-04-08 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Fused bicyclic compounds interacting with the histamine h4 receptor |
| WO2009047255A1 (en) | 2007-10-09 | 2009-04-16 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
-
2008
- 2008-01-02 EP EP08100015A patent/EP2077263A1/en not_active Ceased
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2009
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- 2009-01-02 PL PL09700137T patent/PL2238119T3/pl unknown
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- 2009-01-02 AU AU2009203124A patent/AU2009203124B2/en not_active Ceased
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- 2009-01-02 US US12/811,547 patent/US8530486B2/en not_active Expired - Fee Related
- 2009-01-02 ES ES09700137.4T patent/ES2562674T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011508756A (ja) | 2011-03-17 |
| ES2562674T3 (es) | 2016-03-07 |
| WO2009083608A1 (en) | 2009-07-09 |
| EP2077263A1 (en) | 2009-07-08 |
| WO2009083608A9 (en) | 2009-09-24 |
| EP2238119B1 (en) | 2015-11-25 |
| US20100298322A1 (en) | 2010-11-25 |
| PL2238119T3 (pl) | 2016-05-31 |
| JP5419892B2 (ja) | 2014-02-19 |
| EP2238119A1 (en) | 2010-10-13 |
| AU2009203124A1 (en) | 2009-07-09 |
| US8530486B2 (en) | 2013-09-10 |
| AU2009203124B2 (en) | 2012-03-15 |
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