JP5406018B2 - ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 - Google Patents

５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 Download PDF

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JP5406018B2
JP5406018B2 JP2009511067A JP2009511067A JP5406018B2 JP 5406018 B2 JP5406018 B2 JP 5406018B2 JP 2009511067 A JP2009511067 A JP 2009511067A JP 2009511067 A JP2009511067 A JP 2009511067A JP 5406018 B2 JP5406018 B2 JP 5406018B2
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phenyl
methyl
pyrazol
amino
ethoxy
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JP2009537545A5 (enExample
JP2009537545A (ja
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ブラッドリー ティーガーデン，
デニス チャップマン，
チュイ チョウイ，
コンラート フェイヒティンガー，
サンドン ハン，
ホナッパ ジャヤクマール，
スイ−アン トラン，
チンドン スー，
ニン チョウ，
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アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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JP2009511067A 2006-05-18 2007-05-17 ５−ｈｔ２ａセロトニンレセプターに関連する障害の処置に有用な５−ｈｔ２ａセロトニンレセプターのモジュレーターとしての１級アミン、およびその誘導体 Expired - Fee Related JP5406018B2 (ja)

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US80179906P 2006-05-18 2006-05-18
US60/801,799 2006-05-18
PCT/US2007/011834 WO2007136703A1 (en) 2006-05-18 2007-05-17 Primary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

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JP2009537545A JP2009537545A (ja) 2009-10-29
JP2009537545A5 JP2009537545A5 (enExample) 2010-06-24
JP5406018B2 true JP5406018B2 (ja) 2014-02-05

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US (7) US8148417B2 (enExample)
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WO (1) WO2007136703A1 (enExample)

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US20090197935A1 (en) 2009-08-06
US20150265576A1 (en) 2015-09-24
US8148417B2 (en) 2012-04-03
US20170189381A1 (en) 2017-07-06
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USRE45336E1 (en) 2015-01-13
US20140235622A1 (en) 2014-08-21
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US20120270861A1 (en) 2012-10-25
US8664258B2 (en) 2014-03-04

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