JP5404601B2 - 新規な３−アミド−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルバルデヒド誘導体 - Google Patents
新規な３−アミド−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルバルデヒド誘導体 Download PDFInfo
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- JP5404601B2 JP5404601B2 JP2010502601A JP2010502601A JP5404601B2 JP 5404601 B2 JP5404601 B2 JP 5404601B2 JP 2010502601 A JP2010502601 A JP 2010502601A JP 2010502601 A JP2010502601 A JP 2010502601A JP 5404601 B2 JP5404601 B2 JP 5404601B2
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- dimethyl
- compound
- carbonyl
- tetrahydro
- pharmaceutically acceptable
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- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 164
- -1 tetrahydro-2H-pyran-4-ylmethyl Chemical group 0.000 claims description 57
- 125000000623 heterocyclic group Chemical group 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 7
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
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- GWZSZMRXJHWHCQ-MOPGFXCFSA-N n-[5-[(2s,5r)-2,5-dimethyl-4-(oxan-4-ylmethyl)piperazine-1-carbonyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-1-propan-2-ylimidazole-4-carboxamide Chemical compound CC(C)N1C=NC(C(=O)NC=2C3=C(C(N(C(=O)N4[C@H](CN(CC5CCOCC5)[C@H](C)C4)C)C3)(C)C)NN=2)=C1 GWZSZMRXJHWHCQ-MOPGFXCFSA-N 0.000 claims description 2
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- MVMSOZYFEJAMDJ-CVEARBPZSA-N n-[5-[(2s,5r)-2,5-dimethyl-4-(oxan-4-ylmethyl)piperazine-1-carbonyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-2-methyl-1,3-thiazole-4-carboxamide Chemical compound C([C@H](C)N(C[C@H]1C)C(=O)N2C(C=3NN=C(NC(=O)C=4N=C(C)SC=4)C=3C2)(C)C)N1CC1CCOCC1 MVMSOZYFEJAMDJ-CVEARBPZSA-N 0.000 claims description 2
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- 125000003282 alkyl amino group Chemical group 0.000 claims 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91146207P | 2007-04-12 | 2007-04-12 | |
| US60/911,462 | 2007-04-12 | ||
| US3551908P | 2008-03-11 | 2008-03-11 | |
| US61/035,519 | 2008-03-11 | ||
| US4011508P | 2008-03-27 | 2008-03-27 | |
| US61/040,115 | 2008-03-27 | ||
| PCT/IB2008/000862 WO2008125945A2 (en) | 2007-04-12 | 2008-04-10 | 3-amido-pyrrolo [3, 4-c] pyrazole-5 (1h, 4h, 6h) carbaldehyde derivatives as inhibitors of protein kinase c |
Publications (3)
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| JP2010523643A JP2010523643A (ja) | 2010-07-15 |
| JP2010523643A5 JP2010523643A5 (https=) | 2011-05-19 |
| JP5404601B2 true JP5404601B2 (ja) | 2014-02-05 |
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| JP2010502601A Expired - Fee Related JP5404601B2 (ja) | 2007-04-12 | 2008-04-10 | 新規な３−アミド−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルバルデヒド誘導体 |
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| US (2) | US8114871B2 (https=) |
| EP (1) | EP2195321B1 (https=) |
| JP (1) | JP5404601B2 (https=) |
| KR (1) | KR101113387B1 (https=) |
| CN (3) | CN104356136A (https=) |
| AU (1) | AU2008237660B2 (https=) |
| CA (1) | CA2683695C (https=) |
| HK (1) | HK1207067A1 (https=) |
| IL (1) | IL201104A (https=) |
| MX (1) | MX2009010951A (https=) |
| WO (1) | WO2008125945A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2008237660B2 (en) | 2007-04-12 | 2011-12-22 | Pfizer Inc. | 3-amido-pyrrolo [3, 4-C] pyrazole-5 (1H, 4H, 6H) carbaldehyde derivatives as inhibitors of protein kinase C |
| JP5435592B2 (ja) | 2008-05-28 | 2014-03-05 | ファイザー・インク | ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤 |
| WO2011044264A2 (en) * | 2009-10-06 | 2011-04-14 | Afraxis, Inc. | Pyrrolopyrazoles for treating cns disorders |
| EP2947082A1 (en) | 2009-11-10 | 2015-11-25 | Pfizer Inc | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS |
| WO2011090738A2 (en) | 2009-12-29 | 2011-07-28 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
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| JP2007506787A (ja) * | 2003-09-23 | 2007-03-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとしてのピラゾロピロール誘導体 |
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| KR20090130039A (ko) | 2009-12-17 |
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| AU2008237660A1 (en) | 2008-10-23 |
| US8114871B2 (en) | 2012-02-14 |
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| CA2683695C (en) | 2013-06-18 |
| US20100249128A1 (en) | 2010-09-30 |
| KR101113387B1 (ko) | 2012-04-23 |
| WO2008125945A2 (en) | 2008-10-23 |
| CN104356136A (zh) | 2015-02-18 |
| CA2683695A1 (en) | 2008-10-23 |
| CN101675052A (zh) | 2010-03-17 |
| WO2008125945A3 (en) | 2009-03-12 |
| HK1207067A1 (en) | 2016-01-22 |
| AU2008237660B2 (en) | 2011-12-22 |
| JP2010523643A (ja) | 2010-07-15 |
| US20120108588A1 (en) | 2012-05-03 |
| IL201104A (en) | 2017-09-28 |
| US8999981B2 (en) | 2015-04-07 |
| CN104370914B (zh) | 2018-09-07 |
| HK1207068A1 (en) | 2016-01-22 |
| EP2195321A2 (en) | 2010-06-16 |
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