JP5400388B2 - キナーゼインヒビターおよびその利用 - Google Patents
キナーゼインヒビターおよびその利用 Download PDFInfo
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- JP5400388B2 JP5400388B2 JP2008545992A JP2008545992A JP5400388B2 JP 5400388 B2 JP5400388 B2 JP 5400388B2 JP 2008545992 A JP2008545992 A JP 2008545992A JP 2008545992 A JP2008545992 A JP 2008545992A JP 5400388 B2 JP5400388 B2 JP 5400388B2
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- Prior art keywords
- exo
- hept
- diamine
- racemic
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| US60/751,393 | 2005-12-15 | ||
| PCT/US2006/062162 WO2007070872A1 (en) | 2005-12-15 | 2006-12-15 | Kinase inhibitors and their uses |
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| JP2009519979A JP2009519979A (ja) | 2009-05-21 |
| JP2009519979A5 JP2009519979A5 (cg-RX-API-DMAC7.html) | 2010-02-04 |
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| CA2606760C (en) * | 2005-05-04 | 2014-12-23 | Renovis, Inc. | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and disfunctions |
| JP5400388B2 (ja) * | 2005-12-15 | 2014-01-29 | ライジェル ファーマシューティカルズ， インコーポレイテッド | キナーゼインヒビターおよびその利用 |
| TW201336514A (zh) * | 2006-04-13 | 2013-09-16 | Alcon Res Ltd | ＲＮＡ干擾（ＲＮＡｉ）所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用（二） |
| US8097630B2 (en) | 2006-10-10 | 2012-01-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors |
| NZ577197A (en) | 2006-12-08 | 2011-02-25 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| RU2009128982A (ru) | 2006-12-28 | 2011-02-10 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Пиразолопиримидиновые соединения |
| EP2170395A1 (en) * | 2007-07-02 | 2010-04-07 | Wyeth LLC | Modulators of axl for use in treating bone disorders |
| WO2009020990A1 (en) * | 2007-08-08 | 2009-02-12 | Smithkline Beecham Corporation | 2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d] pyrimidin-4-yl) amino] benzamide derivatives as igf-1r inhibitors for the treatment of cancer |
| WO2009029682A1 (en) * | 2007-08-28 | 2009-03-05 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
| WO2009032703A1 (en) * | 2007-08-28 | 2009-03-12 | Irm Llc | 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors |
| WO2009062112A2 (en) | 2007-11-09 | 2009-05-14 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as antimicrobials |
| JP5489235B2 (ja) * | 2007-11-15 | 2014-05-14 | ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド | Ｎ含有複素環式化合物 |
| TW200942537A (en) * | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| AU2009244897B2 (en) | 2008-04-16 | 2014-11-13 | Alexion Pharmaceuticals, Inc. | 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors |
| US8258144B2 (en) * | 2008-04-22 | 2012-09-04 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CN102131390A (zh) | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
| JP5512665B2 (ja) | 2008-06-20 | 2014-06-04 | ジェネンテック， インコーポレイテッド | トリアゾロピリジンｊａｋ阻害剤化合物と方法 |
| JP5858789B2 (ja) | 2009-01-16 | 2016-02-10 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 転移性癌の予防、治療、または管理のための併用療法に用いるためのａｘｌ阻害薬 |
| AU2010210986A1 (en) * | 2009-02-09 | 2011-08-25 | Supergen, Inc. | Pyrrolopyrimidinyl Axl kinase inhibitors |
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| CN105037364B (zh) * | 2009-04-03 | 2018-04-27 | 维拉斯通股份有限公司 | 作为激酶抑制剂的嘧啶取代的嘌呤化合物 |
| JP2013501002A (ja) | 2009-07-30 | 2013-01-10 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｓｙｋキナーゼ阻害剤としての化合物および組成物 |
| TW201105669A (en) * | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| SG178273A1 (en) * | 2009-08-07 | 2012-03-29 | Merck Patent Gmbh | Novel azaheterocyclic compounds |
| KR101094446B1 (ko) | 2009-11-19 | 2011-12-15 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물 |
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| FR2967854A1 (fr) * | 2010-11-19 | 2012-05-25 | France Telecom | Procede de communication dans un reseau cooperatif |
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| EP1960372A1 (en) | 2008-08-27 |
| US7601713B2 (en) | 2009-10-13 |
| JP2009519979A (ja) | 2009-05-21 |
| ES2562428T3 (es) | 2016-03-04 |
| US9096542B2 (en) | 2015-08-04 |
| US20100069369A1 (en) | 2010-03-18 |
| US20070142402A1 (en) | 2007-06-21 |
| US8053434B2 (en) | 2011-11-08 |
| EP1960372B1 (en) | 2015-12-09 |
| CA2633035A1 (en) | 2007-06-21 |
| CA2633035C (en) | 2016-05-10 |
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