JP5383481B2 - ファージに由来する抗微生物活性 - Google Patents

ファージに由来する抗微生物活性

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Publication number
JP5383481B2
JP5383481B2 JP2009509770A JP2009509770A JP5383481B2 JP 5383481 B2 JP5383481 B2 JP 5383481B2 JP 2009509770 A JP2009509770 A JP 2009509770A JP 2009509770 A JP2009509770 A JP 2009509770A JP 5383481 B2 JP5383481 B2 JP 5383481B2
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JP
Japan
Prior art keywords
polypeptide
phage
protein
sequence
cell wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009509770A
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English (en)
Japanese (ja)
Other versions
JP2009536033A5 (enExample
JP2009536033A (ja
Inventor
スリラム パドマナバン
ビベク ダニエル ポール
アール サンジーブ サラバナン
バラシィ スリラム
Original Assignee
ガンガゲン インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5383481(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ガンガゲン インコーポレーテッド filed Critical ガンガゲン インコーポレーテッド
Publication of JP2009536033A publication Critical patent/JP2009536033A/ja
Publication of JP2009536033A5 publication Critical patent/JP2009536033A5/ja
Application granted granted Critical
Publication of JP5383481B2 publication Critical patent/JP5383481B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009509770A 2006-05-05 2007-05-04 ファージに由来する抗微生物活性 Expired - Fee Related JP5383481B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79788506P 2006-05-05 2006-05-05
US60/797,885 2006-05-05
US90934007P 2007-03-30 2007-03-30
US60/909,340 2007-03-30
PCT/US2007/010972 WO2007130655A2 (en) 2006-05-05 2007-05-04 Phage derived antimicrobial activities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013206059A Division JP5882968B2 (ja) 2006-05-05 2013-10-01 ファージに由来する抗微生物活性

Publications (3)

Publication Number Publication Date
JP2009536033A JP2009536033A (ja) 2009-10-08
JP2009536033A5 JP2009536033A5 (enExample) 2010-06-17
JP5383481B2 true JP5383481B2 (ja) 2014-01-08

Family

ID=38668376

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009509770A Expired - Fee Related JP5383481B2 (ja) 2006-05-05 2007-05-04 ファージに由来する抗微生物活性
JP2013206059A Active JP5882968B2 (ja) 2006-05-05 2013-10-01 ファージに由来する抗微生物活性
JP2016019695A Expired - Fee Related JP6416803B2 (ja) 2006-05-05 2016-02-04 ファージに由来する抗微生物活性
JP2018188797A Expired - Fee Related JP6685360B2 (ja) 2006-05-05 2018-10-04 ファージに由来する抗微生物活性

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2013206059A Active JP5882968B2 (ja) 2006-05-05 2013-10-01 ファージに由来する抗微生物活性
JP2016019695A Expired - Fee Related JP6416803B2 (ja) 2006-05-05 2016-02-04 ファージに由来する抗微生物活性
JP2018188797A Expired - Fee Related JP6685360B2 (ja) 2006-05-05 2018-10-04 ファージに由来する抗微生物活性

Country Status (10)

Country Link
US (6) US8202516B2 (enExample)
EP (1) EP2037946B2 (enExample)
JP (4) JP5383481B2 (enExample)
CN (3) CN101437532B (enExample)
CA (1) CA2651125C (enExample)
DK (1) DK2037946T3 (enExample)
ES (1) ES2536852T3 (enExample)
MX (1) MX2008014150A (enExample)
PT (1) PT2037946E (enExample)
WO (1) WO2007130655A2 (enExample)

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EP2157100A1 (en) * 2008-08-19 2010-02-24 Profos AG Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins
US8563504B2 (en) * 2008-10-10 2013-10-22 Lusomedicamenta, S.A. Antibacterial phage peptides and methods of use thereof
EP2338916A1 (en) 2009-12-23 2011-06-29 Hyglos Invest GmbH Chimeric polypeptides and their use in bacterial decoloniation
EP2397548A1 (en) 2010-06-18 2011-12-21 Hyglos Invest GmbH Methods of generating and screening for lytic chimeric polypeptides
ES2825050T3 (es) * 2010-09-17 2021-05-14 Tecnifar Ind Tecnica Farmaceutica S A Fago antibacteriano, péptidos de fago y métodos de uso de los mismos
CA2833176C (en) 2011-04-12 2023-05-16 C.B. Appaiah Chimeric antibacterial polypeptides
PL394619A1 (pl) * 2011-04-19 2012-10-22 Miedzynarodowy Instytut Biologii Molekularnej I Komórkowej Sposób proteolizy, peptydaza, kompozycja do stosowania jako srodek bakteriostatyczny lub bakteriobójczy, zestaw oraz zastosowania aktywnej formy LytM z S. aureus lub jej pochodnej
SG11201406112TA (en) * 2012-03-27 2014-10-30 Genentech Inc Improved harvest operations for recombinant proteins
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KR101381336B1 (ko) 2012-06-25 2014-04-25 주식회사 씨티씨바이오 신규한 박테리오파지 ｐｖｐ-1 및 이의 비브리오 파라헤몰리티쿠스 증식 억제 용도
WO2013191363A1 (ko) * 2012-06-22 2013-12-27 주식회사 씨티씨바이오 신규한 박테리오파지 및 병원성 박테리아 증식 억제 용도
US8980614B2 (en) * 2012-09-06 2015-03-17 The United States Of America, As Represented By The Secretary Of Agriculture Staphylococcus haemolyticus prophage φSH2 endolysin is lytic for Staphylococcus aureus
CN106795506B (zh) * 2014-05-14 2020-11-27 达特茅斯学院理事会 去免疫化溶葡萄球菌酶和使用方法
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN109312296B (zh) * 2016-06-14 2023-05-05 帝斯曼知识产权资产管理有限公司 重组酵母细胞
US20190282673A1 (en) * 2016-08-26 2019-09-19 Gangagen, Inc. Staphtame activity on biofilms
CN106635942B (zh) * 2016-12-05 2020-05-29 齐鲁工业大学 一种芽孢表面稳定展示海藻糖合酶的工程菌及其构建方法
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11236314B2 (en) * 2017-03-30 2022-02-01 Bactoclear Holdings Pte. Ltd Chimeric lysm polypeptides
KR20240162610A (ko) * 2017-04-03 2024-11-15 사시나파스 컴퍼니 리미티드 조작된 그람-음성 엔도리신
CN107502603B (zh) * 2017-09-06 2018-06-05 江苏省农业科学院 一种大肠杆菌裂解酶及其制备方法与应用
CN107828769B (zh) * 2017-09-28 2021-03-02 昆明理工大学 一种耐热裂解酶MMPpgh和编码此酶的多核苷酸
DK3723488T3 (da) 2017-12-14 2025-10-27 Bactoclear Holdings Pte Ltd Terapeutiske bakteriociner
JP7034724B2 (ja) * 2018-01-16 2022-03-14 花王株式会社 ケラチン断片の製造方法
CN113366103A (zh) * 2018-12-21 2021-09-07 诺维信公司 具有肽聚糖降解活性的多肽以及编码其的多核苷酸
KR20220007123A (ko) * 2019-05-08 2022-01-18 파고메드 바이오파르마 게엠베하 신규 가드네렐라 엔도리신 및 이의 용도
WO2021048257A1 (en) * 2019-09-11 2021-03-18 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Bactericidal phage vectors
PL243303B1 (pl) * 2019-10-13 2023-07-31 Miedzynarodowy Inst Biologii Molekularnej I Komorkowej Rekombinowany polipeptyd do zastosowania do leczenia, kompozycje go zawierające oraz jego zastosowania
JP2023510074A (ja) * 2019-10-31 2023-03-13 バクトクリア ホールディングス ピーティーイー エルティーディー． 細菌の選択的溶解のためのキメラタンパク質
CN111187765B (zh) * 2020-02-17 2022-07-15 西北农林科技大学 一种反刍动物瘤胃特异溶菌酶lyz1及其应用
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
KR20240036508A (ko) * 2021-05-13 2024-03-20 포지 바이올로직스, 인크. 아데노바이러스성 헬퍼 플라스미드
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Also Published As

Publication number Publication date
CN105884904A (zh) 2016-08-24
WO2007130655A3 (en) 2008-07-17
DK2037946T3 (en) 2015-04-27
US10278398B2 (en) 2019-05-07
CN105884904B (zh) 2020-06-16
ES2536852T3 (es) 2015-05-28
JP2018201525A (ja) 2018-12-27
CA2651125A1 (en) 2007-11-15
WO2007130655A2 (en) 2007-11-15
JP2009536033A (ja) 2009-10-08
EP2037946B2 (en) 2023-11-01
CN103436507A (zh) 2013-12-11
JP6685360B2 (ja) 2020-04-22
JP6416803B2 (ja) 2018-10-31
JP5882968B2 (ja) 2016-03-09
US20190297896A1 (en) 2019-10-03
CN103436507B (zh) 2016-04-20
MX2008014150A (es) 2009-02-04
US8202516B2 (en) 2012-06-19
EP2037946B1 (en) 2015-02-25
PT2037946E (pt) 2015-06-04
US20120237491A1 (en) 2012-09-20
US20170318817A1 (en) 2017-11-09
US20220053775A1 (en) 2022-02-24
US20090324576A1 (en) 2009-12-31
CA2651125C (en) 2016-06-28
US8748150B2 (en) 2014-06-10
EP2037946A2 (en) 2009-03-25
JP2014050388A (ja) 2014-03-20
JP2016112020A (ja) 2016-06-23
US9622486B2 (en) 2017-04-18
EP2037946A4 (en) 2010-09-22
CN101437532B (zh) 2013-08-21
CN101437532A (zh) 2009-05-20
US20140369986A1 (en) 2014-12-18

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