JP5337151B2 - 粒子を集束するためのシステムおよび方法 - Google Patents

粒子を集束するためのシステムおよび方法 Download PDF

Info

Publication number
JP5337151B2
JP5337151B2 JP2010510958A JP2010510958A JP5337151B2 JP 5337151 B2 JP5337151 B2 JP 5337151B2 JP 2010510958 A JP2010510958 A JP 2010510958A JP 2010510958 A JP2010510958 A JP 2010510958A JP 5337151 B2 JP5337151 B2 JP 5337151B2
Authority
JP
Japan
Prior art keywords
particles
channel
focusing
suspension
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010510958A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010529452A5 (enExample
JP2010529452A (ja
Inventor
アレクサンダー ルシャンスキー
アヴィシャイ ブランスキー
コリン ナタネル
Original Assignee
テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド filed Critical テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド
Publication of JP2010529452A publication Critical patent/JP2010529452A/ja
Publication of JP2010529452A5 publication Critical patent/JP2010529452A5/ja
Application granted granted Critical
Publication of JP5337151B2 publication Critical patent/JP5337151B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0058—Kind of property studied
    • G01N2203/0092—Visco-elasticity, solidification, curing, cross-linking degree, vulcanisation or strength properties of semi-solid materials
    • G01N2203/0094—Visco-elasticity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2010510958A 2007-06-07 2008-06-05 粒子を集束するためのシステムおよび方法 Active JP5337151B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92499807P 2007-06-07 2007-06-07
US60/924,998 2007-06-07
PCT/IL2008/000772 WO2008149365A2 (en) 2007-06-07 2008-06-05 Systems and methods for focusing particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013161659A Division JP5901582B2 (ja) 2007-06-07 2013-08-02 粒子を集束するための方法及び装置

Publications (3)

Publication Number Publication Date
JP2010529452A JP2010529452A (ja) 2010-08-26
JP2010529452A5 JP2010529452A5 (enExample) 2011-07-07
JP5337151B2 true JP5337151B2 (ja) 2013-11-06

Family

ID=39800715

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010510958A Active JP5337151B2 (ja) 2007-06-07 2008-06-05 粒子を集束するためのシステムおよび方法
JP2013161659A Active JP5901582B2 (ja) 2007-06-07 2013-08-02 粒子を集束するための方法及び装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013161659A Active JP5901582B2 (ja) 2007-06-07 2013-08-02 粒子を集束するための方法及び装置

Country Status (5)

Country Link
US (2) US8642288B2 (enExample)
EP (1) EP2153199B1 (enExample)
JP (2) JP5337151B2 (enExample)
CN (2) CN103543093B (enExample)
WO (1) WO2008149365A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504764A (ja) * 2008-10-02 2012-02-23 ピクセル メディカル テクノロジーズ リミテッド 粘弾性フォーカシングに基づく光学的撮像
JP6116490B2 (ja) 2011-03-09 2017-04-19 ピクセル メディカル テクノロジーズ リミテッド 分析対象の細胞を含む試料流体の調製に用いる使い捨てカートリッジ
GB201113309D0 (en) * 2011-08-02 2011-09-14 Izon Science Ltd Characterisation of particles
RU2015101834A (ru) * 2012-06-22 2016-08-10 Малверн Инструментс Лимитед Определение характеристик гетерогенных флюидных проб
US10509976B2 (en) 2012-06-22 2019-12-17 Malvern Panalytical Limited Heterogeneous fluid sample characterization
US20150362421A1 (en) * 2012-06-22 2015-12-17 Malvern Instruments Limited Particle characterization
US9669403B2 (en) * 2012-07-25 2017-06-06 Sony Corporation Microparticle measurement device and liquid delivery method in microparticle measurement device
US9372144B2 (en) * 2013-10-01 2016-06-21 Owl biomedical, Inc. Particle manipulation system with out-of-plane channel
KR102095617B1 (ko) 2013-03-15 2020-03-31 아이리스 인터내셔널 인크. 혈액 샘플에서의 입자 분석을 위한 오토포커스 시스템 및 방법
KR102053487B1 (ko) 2013-03-15 2019-12-06 아이리스 인터내셔널 인크. 혈액 샘플에서의 입자 분석을 위한 시스 유체 시스템 및 방법
WO2015033090A1 (en) * 2013-09-03 2015-03-12 Izon Science Limited Measurement of particle charge
US10307760B2 (en) 2014-01-30 2019-06-04 The General Hospital Corporation Inertio-elastic focusing of particles in microchannels
EP2907574A1 (en) 2014-02-13 2015-08-19 OWL Biobedical, Inc. Microfluidic system with viscoelastic fluid
JP6927879B2 (ja) 2015-01-14 2021-09-01 ピクセル メディカル テクノロジーズ リミテッド 試料流体分析用の使い捨てカートリッジ
RU2655225C1 (ru) * 2015-04-17 2018-05-24 Конинклейке Филипс Н.В. Обработка пыли
KR101855490B1 (ko) * 2016-01-22 2018-05-08 한국과학기술원 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법
JP6134402B1 (ja) * 2016-01-29 2017-05-24 シスメックス株式会社 生体試料撮像装置及び生体試料撮像方法
CN106248528A (zh) * 2016-09-27 2016-12-21 中国石油天然气股份有限公司 一种聚合物弹性强弱的评价方法
US11474023B2 (en) 2017-06-02 2022-10-18 The General Hospital Corporation Oscillatory focusing of particles in channels
CN108627448A (zh) * 2018-06-05 2018-10-09 江苏卓微生物科技有限公司 微粒计数的方法
US11185861B2 (en) 2018-06-13 2021-11-30 International Business Machines Corporation Multistage deterministic lateral displacement device for particle separation
WO2022072503A1 (en) * 2020-09-29 2022-04-07 1087 Systems, Inc Graded bioprocess monitoring and fluid self-modulation
EP4083607A1 (en) 2021-04-26 2022-11-02 ETH Zurich Method and microfluidic device for studying cell deformations
JP7152622B1 (ja) * 2022-03-30 2022-10-12 ポーラ化成工業株式会社 ウルトラファインバブルの気泡濃度測定方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS576338A (en) * 1980-06-12 1982-01-13 Kyoto Daiichi Kagaku:Kk Method and device for measuring degree of flocculation of finely divided particles quantitatively
FR2621123B1 (fr) * 1987-09-30 1989-12-01 Commissariat Energie Atomique Procede de fabrication d'un dispositif d'analyse optique d'un flux de microparticules et application a la fabrication d'un cytofluorimetre
JP2813988B2 (ja) * 1989-08-08 1998-10-22 東亜医用電子株式会社 赤血球変形能測定方法及び装置
JP3467310B2 (ja) * 1994-04-21 2003-11-17 シスメックス株式会社 白血球分析用試薬及び白血球の分類方法
FR2734637B1 (fr) * 1995-05-24 1997-08-14 Abx Sa Dispositif d'inspection optique d'un fluide, notamment pour analyses hematologiques
JPH09126989A (ja) * 1995-11-07 1997-05-16 Hitachi Ltd フロー式粒子画像解析装置
US5808737A (en) * 1996-02-29 1998-09-15 Sienna Biotech, Inc. Pre-analysis chamber for a flow particle analyzer
JPH09318523A (ja) * 1996-05-29 1997-12-12 Toa Medical Electronics Co Ltd パラメータ解析方法及びそれを用いた装置
US6723290B1 (en) * 1998-03-07 2004-04-20 Levine Robert A Container for holding biologic fluid for analysis
JP2003507026A (ja) * 1999-08-13 2003-02-25 ユー．エス．ジェノミクス，インコーポレーテッド ポリマーを引き伸ばす方法および装置
AU2606301A (en) * 1999-12-29 2001-07-09 Union Biometrica, Inc. High viscosity sheath reagent for flow cytometry
US20040070757A1 (en) * 2000-12-29 2004-04-15 Moore Richard Channing High viscosity sheath reagent for flow cytometry
AU2002320507A1 (en) * 2001-07-13 2003-01-29 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
CA2458802C (en) * 2001-09-06 2016-06-07 Genomic Profiling Systems, Inc. Rapid and sensitive detection of molecules
US6746872B2 (en) * 2002-01-16 2004-06-08 Lifescan, Inc. Control compositions and methods of use for coagulation tests
JP2003302330A (ja) * 2002-04-12 2003-10-24 Asahi Kasei Corp 平板状フローセル装置
US6794671B2 (en) * 2002-07-17 2004-09-21 Particle Sizing Systems, Inc. Sensors and methods for high-sensitivity optical particle counting and sizing
US7115230B2 (en) * 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
SG150506A1 (en) * 2004-02-13 2009-03-30 Univ North Carolina State Functional materials and novel methods for the fabrication of microfluidic devices
JP4528664B2 (ja) * 2004-04-22 2010-08-18 興和株式会社 蛍光粒子計数装置
ITBO20040420A1 (it) * 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
US7811438B2 (en) * 2004-12-08 2010-10-12 Palo Alto Research Center Incorporated Bio-enrichment device to enhance sample collection and detection
US8186913B2 (en) * 2007-04-16 2012-05-29 The General Hospital Corporation Systems and methods for particle focusing in microchannels

Also Published As

Publication number Publication date
WO2008149365A2 (en) 2008-12-11
CN103543093B (zh) 2016-08-10
CN103543093A (zh) 2014-01-29
WO2008149365A3 (en) 2009-03-05
CN101772697B (zh) 2013-08-21
US20140113358A1 (en) 2014-04-24
EP2153199B1 (en) 2016-10-19
US9470679B2 (en) 2016-10-18
JP5901582B2 (ja) 2016-04-13
US20100178666A1 (en) 2010-07-15
EP2153199A2 (en) 2010-02-17
JP2013217946A (ja) 2013-10-24
JP2010529452A (ja) 2010-08-26
US8642288B2 (en) 2014-02-04
CN101772697A (zh) 2010-07-07

Similar Documents

Publication Publication Date Title
JP5337151B2 (ja) 粒子を集束するためのシステムおよび方法
JP7354368B2 (ja) マイクロ流体チャネルを使用してマイクロ粒子のバルク選別を行う方法及び装置
Yun et al. Cell manipulation in microfluidics
US11633737B2 (en) Microfluidic chip for focussing a stream of particulate containing fluid
KR20060090596A (ko) 셀 소터 칩
JP2010538241A (ja) マイクロチャネルにおける粒子集束のためのシステムおよび方法
JP7228250B2 (ja) 分散された粒子を有する流体試料を分析するための方法および装置
JP2018524591A (ja) 粘度測定
US20220146405A1 (en) Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics
US20230415153A1 (en) Microfluidic devices and method for sampling and analysis of cells using optical forces and raman spectroscopy
JP7758352B2 (ja) 体液解析用流体装置および関連方法
CN114112826A (zh) 用于荧光微粒的声光互联微流控检测系统和检测方法
Yun et al. Effect of a dual inlet channel on cell loading in microfluidics
HK1145538A (en) Systems and methods for focusing particles
Augustsson et al. Acoustophoresis in tumor cell enrichment
Kumari et al. Microfluidic Platforms for Single Cell Analysis: Applications in Cellular Manipulation Optical Biosensing, Chemosensors 2023, Vol. 11, No. 2, 2023
US20170146442A1 (en) Biomimetic liquid particles, method and device for flow cytometer measurement
CN113826000A (zh) 用于颗粒尺寸测量中修正的方法及设备

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110519

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110519

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20120515

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130123

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130423

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130703

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130802

R150 Certificate of patent or registration of utility model

Ref document number: 5337151

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250