JP5317697B2 - 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療 - Google Patents

抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療 Download PDF

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JP5317697B2
JP5317697B2 JP2008529863A JP2008529863A JP5317697B2 JP 5317697 B2 JP5317697 B2 JP 5317697B2 JP 2008529863 A JP2008529863 A JP 2008529863A JP 2008529863 A JP2008529863 A JP 2008529863A JP 5317697 B2 JP5317697 B2 JP 5317697B2
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antibody
dsg3
chain
seq
amino acid
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JPWO2008020586A1 (ja
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浩幸 油谷
俊平 石川
浩孝 伊藤
清孝 中野
重人 川合
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Chugai Pharmaceutical Co Ltd
University of Tokyo NUC
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Chugai Pharmaceutical Co Ltd
University of Tokyo NUC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2008529863A 2006-08-14 2007-08-14 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療 Active JP5317697B2 (ja)

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JP2008529863A JP5317697B2 (ja) 2006-08-14 2007-08-14 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療

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JP2006221230 2006-08-14
JP2006221230 2006-08-14
JP2007019108 2007-01-30
JP2007019108 2007-01-30
PCT/JP2007/065834 WO2008020586A1 (fr) 2006-08-14 2007-08-14 diagnostic et traitement du cancer à l'aide de l'anticorps anti-desmogléine-3
JP2008529863A JP5317697B2 (ja) 2006-08-14 2007-08-14 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療

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JP5317697B2 true JP5317697B2 (ja) 2013-10-16

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JP2013043041A Active JP5651726B2 (ja) 2006-08-14 2013-03-05 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療
JP2014175480A Active JP5972325B2 (ja) 2006-08-14 2014-08-29 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療
JP2016137228A Active JP6162864B2 (ja) 2006-08-14 2016-07-12 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療

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JP2014175480A Active JP5972325B2 (ja) 2006-08-14 2014-08-29 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療
JP2016137228A Active JP6162864B2 (ja) 2006-08-14 2016-07-12 抗Ｄｅｓｍｏｇｌｅｉｎ３抗体を用いる癌の診断および治療

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US (2) US20100092457A1 (enExample)
EP (3) EP2548576B1 (enExample)
JP (4) JP5317697B2 (enExample)
AU (1) AU2007285217B2 (enExample)
BR (1) BRPI0713086A2 (enExample)
CA (1) CA2658050A1 (enExample)
WO (1) WO2008020586A1 (enExample)

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JP2015003912A (ja) 2015-01-08
EP2050466B1 (en) 2015-10-28
EP2548576A1 (en) 2013-01-23
JP6162864B2 (ja) 2017-07-12
CA2658050A1 (en) 2008-02-21
AU2007285217A1 (en) 2008-02-21
US20100092457A1 (en) 2010-04-15
BRPI0713086A2 (pt) 2012-10-09
JP2016185981A (ja) 2016-10-27
EP2050466A1 (en) 2009-04-22
JP2013189433A (ja) 2013-09-26
JPWO2008020586A1 (ja) 2010-01-07
EP2050466A4 (en) 2010-04-28
JP5651726B2 (ja) 2015-01-14
US20170152314A1 (en) 2017-06-01
WO2008020586A1 (fr) 2008-02-21
EP3111955A1 (en) 2017-01-04
JP5972325B2 (ja) 2016-08-17
EP3111955B1 (en) 2019-01-23
US10696743B2 (en) 2020-06-30
AU2007285217B2 (en) 2013-02-07
EP2548576B1 (en) 2016-11-30

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