JP5313660B2 - Ｈｇｆ／ｈｇｆｒ活性の観察と調節 - Google Patents

Ｈｇｆ／ｈｇｆｒ活性の観察と調節 Download PDF

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JP5313660B2
JP5313660B2 JP2008504520A JP2008504520A JP5313660B2 JP 5313660 B2 JP5313660 B2 JP 5313660B2 JP 2008504520 A JP2008504520 A JP 2008504520A JP 2008504520 A JP2008504520 A JP 2008504520A JP 5313660 B2 JP5313660 B2 JP 5313660B2
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hgf
hgfr
antibody
protein
cells
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JP2008538551A (ja
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デトマー，ミヒャエル
健太朗 加治屋
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ザ ジェネラル ホスピタル コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
JP2008504520A 2005-03-31 2006-03-30 Ｈｇｆ／ｈｇｆｒ活性の観察と調節 Expired - Fee Related JP5313660B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66746305P 2005-03-31 2005-03-31
US60/667,463 2005-03-31
PCT/US2006/012389 WO2006105511A1 (en) 2005-03-31 2006-03-30 Monitoring and modulating hgf/hgfr activity

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2010109852A Division JP4664441B2 (ja) 2005-03-31 2010-05-12 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2012090431A Division JP2012149087A (ja) 2005-03-31 2012-04-11 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2013043836A Division JP5801835B2 (ja) 2005-03-31 2013-03-06 Ｈｇｆ／ｈｇｆｒ活性の観察と調節

Publications (2)

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JP2008538551A JP2008538551A (ja) 2008-10-30
JP5313660B2 true JP5313660B2 (ja) 2013-10-09

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JP2008504520A Expired - Fee Related JP5313660B2 (ja) 2005-03-31 2006-03-30 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2010109852A Expired - Fee Related JP4664441B2 (ja) 2005-03-31 2010-05-12 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2012090431A Pending JP2012149087A (ja) 2005-03-31 2012-04-11 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2013043836A Expired - Fee Related JP5801835B2 (ja) 2005-03-31 2013-03-06 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2013149577A Expired - Fee Related JP5722960B2 (ja) 2005-03-31 2013-07-18 Ｈｇｆ／ｈｇｆｒ活性の観察と調節

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JP2010109852A Expired - Fee Related JP4664441B2 (ja) 2005-03-31 2010-05-12 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2012090431A Pending JP2012149087A (ja) 2005-03-31 2012-04-11 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2013043836A Expired - Fee Related JP5801835B2 (ja) 2005-03-31 2013-03-06 Ｈｇｆ／ｈｇｆｒ活性の観察と調節
JP2013149577A Expired - Fee Related JP5722960B2 (ja) 2005-03-31 2013-07-18 Ｈｇｆ／ｈｇｆｒ活性の観察と調節

Country Status (10)

Country Link
US (4) US20070010443A1 (enExample)
EP (2) EP2674165B1 (enExample)
JP (5) JP5313660B2 (enExample)
KR (3) KR20130114763A (enExample)
CN (2) CN101189023B (enExample)
DK (1) DK1863519T3 (enExample)
ES (1) ES2440953T3 (enExample)
PL (1) PL1863519T3 (enExample)
TW (1) TWI362940B (enExample)
WO (1) WO2006105511A1 (enExample)

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CN105209483B (zh) * 2013-05-31 2021-07-27 分子组合公司 与肝细胞生长因子结合的设计锚蛋白重复蛋白
KR20170136536A (ko) 2015-03-16 2017-12-11 셀덱스 쎄라퓨틱스, 인크. 항-met 항체 및 그 사용 방법
KR101843248B1 (ko) * 2015-03-17 2018-03-29 고려대학교 세종산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
WO2017019454A2 (en) 2015-07-28 2017-02-02 Musc Foundation For Research Development Identification of novel anti-fibrotic peptide in c-terminal region of the met receptor tyrosine kinase
CN109535243B (zh) * 2019-01-07 2019-09-24 北京诺思兰德生物技术股份有限公司 人肝细胞生长因子突变体及其应用
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US20100227821A1 (en) 2010-09-09
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JP2012149087A (ja) 2012-08-09
CN102989012A (zh) 2013-03-27
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ES2440953T3 (es) 2014-01-31
CN101189023B (zh) 2013-01-30
CN102989012B (zh) 2015-05-13
JP4664441B2 (ja) 2011-04-06
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TW200722099A (en) 2007-06-16
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HK1183441A1 (en) 2013-12-27
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JP2010265266A (ja) 2010-11-25
JP2013136622A (ja) 2013-07-11
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