JP5300480B2 - バニラプラニフォリア抽出物及びその抽出工程、並びにそれを含有する化粧用組成物、若しくは皮膚科用組成物 - Google Patents
バニラプラニフォリア抽出物及びその抽出工程、並びにそれを含有する化粧用組成物、若しくは皮膚科用組成物 Download PDFInfo
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- 235000016831 stigmasterol Nutrition 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- PSVXZQVXSXSQRO-UHFFFAOYSA-N undecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO PSVXZQVXSXSQRO-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Birds (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(1)アルコール抽出法バニラプラニフォリアの種子鞘0.5kgをナイフミル(RETSCH社製)で粉砕し、還流装置を備える5Lのガラス製反応容器に入れる。上記反応容器に96.3%エタノール2.5Lを加え、1時間加熱する。その後、一晩冷浸する。翌朝、内容物を濾過し、反応容器を空にする。抽出物を含む溶媒は保管しておく。上記粉砕したバニラ種子鞘を再び96.3%エタノール2.5Lと共にガラス製反応容器に入れ、約80℃で4時間加熱還流する。内容物を濾過し、反応容器を空にする。得られた2つの濾液を混ぜ合わせる。その後、真空下で、溶媒を回転蒸発器によって蒸発させる。このようにして、0.155kgのバニラプラニフォリアのオレオレジンが得られる。収率:31%
(1)実施例1の要領で得られたバニラプラニフォリア抽出物100mgを、1N塩酸メタノール溶液2ml中で可溶化する。上記溶液を撹拌後、80℃で10分間湯煎する。ヘプタン2mlで液液抽出した後、クロマトグラフィーに導入することにより、エステル化した試料を得る。クロマトグラフィーの条件は以下の通りである。気相クロマトグラフィー(Agilent 6890)250℃のインジェクター(スプリット又はスプリットレス)調製した試料0.5μLをスプリット比1:100で導入長さ30m、内径0.25mm、膜厚0.25μmの、100%ポリジメチルシロキサンをコーティングしたキャピラリーカラム(Agilent DB−1)で分離キャリアガス:ヘリウム1ml/分カラムオーブンの初期温度:700℃温度勾配70℃〜250℃(2℃/分)、等温線250℃60分間合計時間:150分検出:炎イオン化検出器(補助ガス:窒素)
(1)ケラチノサイト培養物の調製本手順は、生物活性に関するすべての検査において共通である。新生児包皮由来のケラチノサイト(Clonetics社、San Diego、USA)を6ウェルプレートに播種し、ケラチノサイト増殖用培地(Clonetics社製KBM)、特に、組換えヒトEGF、インスリン、ヒドロコルチゾン、ウシ下垂体抽出物、ゲンタマイシン、アンフォテリシンBを添加した改変培地で培養した。37℃の空気炉で24時間培養した後、凝集した細胞をPBS(Gibco社)で洗浄し、500μg/ml、10μg/ml、1μg/ml、0.1μg/mlの各濃度で検査対象を含む専用の基本培地(Clonetics社製KBM)で24時間インキュベートした。抽出物の細胞毒性を検査後、活性を評価した。すべての検査において、すべての濃度について必ずしも検査していない。
mRNAは、試薬Trizol(Invitrogen社)を製造者の推奨に従って用い、分離した。逆転写は、遺伝子キットAmp RNA PCR(Applied Biosystems社)を製造者の推奨に従って用い、行った。
細胞培養に際しての活性化された増殖因子TGF−β1の濃度について、イムノアッセイキットQuantikine(登録商標)(No.DB100、R&D Systems)を用い、ELISA法で定量的評価を行った。ケラチノサイトの培養条件及び検査対象の試料は、実施例3と同一である。結果を以下の表4に示す。
検査原理検査する物質を、活性化されたMMPと共にインキュベートする。各MMPに特異の蛍光性酵素基質を添加することにより、酵素活性を制御する。
エマルションAセテアリルアルコール+セテアリルグルコシド:4.00%ベヘネス−25:2.00%バニラプラニフォリアの脂溶性画分*:1.00%カンゾウ抽出物:0.10%皮膚軟化剤:35.00%酢酸トコフェロール:0.50%ジメチコン:2.00%EDTA:0.05%グリセリン:5.00%ゲル化剤:2.00%pH調整剤:十分量保存料:十分量水:合計が100.00%となる十分量*実施例1の方法で調製
Claims (7)
- 少なくとも1種類の溶媒を用いてバニラプラニフォリア粉砕物から抽出する工程と、
前記抽出する工程から得られた脂溶性画分を回収する工程と、
前記脂溶性画分を分子蒸留して、油性蒸留液を得る工程と、
を含む方法から得られるバニラプラニフォリアの油性蒸留液であって、
前記脂溶性画分の分子蒸留は、下記の工程;
前記脂溶性画分を、温度100〜250℃、圧力0.1〜0.001mbarで分子蒸留する工程と、
蒸留液を回収する工程と、
からなり、
前記溶媒は、アルコール、グリコール及び有機溶媒からなる群から選択される、油性蒸留液。 - 前記脂溶性画分が、気相クロマトグラフィーで分離した全成分の合計に対する相対パーセントで表した場合に、不飽和モノカルボニル化合物0.5〜10%、不飽和ジカルボニル化合物20〜80%、不飽和ピラノン1〜40%を含む請求項1に記載の油性蒸留液。
- 前記脂溶性画分が、気相クロマトグラフィーで分離した全成分の合計に対する相対パーセントで表した場合に、不飽和モノカルボニル化合物1〜5%、不飽和ジカルボニル化合物35〜65%、不飽和ピラノン3〜25%を含む請求項1又は2に記載の油性蒸留液。
- ペンタコセン−16−オン−2、ヘプタコセン−18−オン−2、及びノナコセン−20−オン−2から選択される不飽和モノカルボニル化合物を含む請求項1乃至3のいずれか記載の油性蒸留液。
- ペンタコセン−16−ジオン−2,4、ヘプタコセン−18−ジオン−2,4、ノナコセン−20−ジオン−2,4、及びヘントリアコンテン−22−ジオン−2,4から選択される不飽和ジカルボニル化合物を含む請求項1乃至4のいずれか記載の油性蒸留液。
- ノナデセニル−2 ジヒドロ−2,3 メチル−6 ピラノン−4、ヘンイコセニル−2 ジヒドロ−2,3 メチル−6 ピラノン−4、及びトリコセニル−2 ジヒドロ−2,3 メチル−6 ピラノン−4から選択される不飽和ピラノンを含む請求項1乃至5のいずれか記載の油性蒸留液。
- 抗老化剤の製造のための、請求項1乃至6のいずれか記載のバニラプラニフォリアの油性蒸留液の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0509767 | 2005-09-23 | ||
FR0509765A FR2891146B1 (fr) | 2005-09-23 | 2005-09-23 | Utilisation d'un extrait de vanille dans une composition cosmetique ou dermatologique pour la prevention et/ou le traitement du vieillissement de la peau. |
FR0509767A FR2891148B1 (fr) | 2005-09-23 | 2005-09-23 | Extrait de vanille, son procede d'obtention, et composition cosmetique ou dermatologique le contenant |
FR0509765 | 2005-09-23 | ||
PCT/FR2006/001312 WO2007034042A2 (fr) | 2005-09-23 | 2006-06-09 | Extrait de vanilla planifolia, son procede d’obtention, et composition cosmetique ou dermatologique le contenant |
Publications (2)
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JP2009508914A JP2009508914A (ja) | 2009-03-05 |
JP5300480B2 true JP5300480B2 (ja) | 2013-09-25 |
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EP (1) | EP1928447B1 (ja) |
JP (1) | JP5300480B2 (ja) |
ES (1) | ES2567131T3 (ja) |
WO (1) | WO2007034042A2 (ja) |
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US9925134B2 (en) | 2006-10-17 | 2018-03-27 | Basf Beauty Care Solutions France Sas | Use of substances to protect FGF-2 or FGF-beta growth factor |
FR2907014B1 (fr) * | 2006-10-17 | 2009-05-15 | Engelhard Lyon Sa | Utilisation d'actifs cosmetiques pour proteger le fibroblaste growth factor-beta ou fgf-2 de la matrice extracellulaire dans le but de restructurer cette matrice |
EP2262469A4 (en) * | 2008-04-15 | 2013-12-04 | Immanence Integrale Dermo Correction Inc | SKIN CARE COMPOSITIONS AND METHODS OF USE |
ITRM20090123A1 (it) * | 2009-03-23 | 2010-09-24 | Marco Nicoletti | Ingrediente attivo alla liquirizia per creme cosmetiche protettive e idratanti, e suo procedimento di preparazione |
JP2013512937A (ja) | 2009-12-07 | 2013-04-18 | シャネル パフュームズ ビューテ | 皮膚のバリア機能を改善するための、arnt2の発現を刺激する活性剤のスクリーニング方法 |
US9228999B2 (en) | 2009-12-07 | 2016-01-05 | Chanel Parfums Beaute | Method for screening active agents that stimulate the expression of CERT to improve the skin's barrier function |
JP5886423B2 (ja) * | 2011-06-16 | 2016-03-16 | シャネル パフュームズ ビューテ | 半透明なシロップ状化粧料組成物 |
US11672266B2 (en) | 2018-03-13 | 2023-06-13 | Symrise Ag | Production of ethanol-free vanilla extracts |
EP4062922B1 (fr) * | 2021-03-22 | 2024-01-10 | Chanel Parfums Beauté | Extrait de swertia chirata et compositions cosmétiques le comprenant |
CN114933677B (zh) * | 2022-05-06 | 2023-03-07 | 四川大学 | 一种基于润滑、pH响应性的环刷状两性离子聚合物及其制备方法和应用 |
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FR2073240A1 (en) * | 1969-12-01 | 1971-10-01 | Gredoire Negypte | Cold creams with pineapple - or ginseng extracts with cosmetic and therapeutic value |
US5766575A (en) * | 1996-06-14 | 1998-06-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Method and composition for skin lightening |
JP4299374B2 (ja) * | 1996-10-08 | 2009-07-22 | 高砂香料工業株式会社 | 細胞賦活剤及びその応用 |
JP2002205933A (ja) * | 2001-01-05 | 2002-07-23 | Ichimaru Pharcos Co Ltd | ラン科植物抽出物含有化粧料組成物 |
FR2837384B1 (fr) * | 2002-03-22 | 2006-06-09 | Cep | Utilisation d'un extrait de vanille pour la protection de la peau et son incorporation dans des preparations cosmetiques et/ou dermatologiques |
WO2004084855A1 (en) * | 2003-03-27 | 2004-10-07 | Medasani Munisekhar | Keratolytic composition with anti-allergic anti-inflammatory properties |
JP3853773B2 (ja) * | 2003-09-19 | 2006-12-06 | 花王株式会社 | 養毛料 |
JP4148862B2 (ja) * | 2003-09-19 | 2008-09-10 | 株式会社ノエビア | チロシナーゼ活性抑制剤 |
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ES2567131T3 (es) | 2016-04-20 |
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