JP5295766B2 - No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 - Google Patents
No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 Download PDFInfo
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- JP5295766B2 JP5295766B2 JP2008524446A JP2008524446A JP5295766B2 JP 5295766 B2 JP5295766 B2 JP 5295766B2 JP 2008524446 A JP2008524446 A JP 2008524446A JP 2008524446 A JP2008524446 A JP 2008524446A JP 5295766 B2 JP5295766 B2 JP 5295766B2
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- Prior art keywords
- arginine
- lipoic acid
- sexual
- dithiolane
- composition
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Description
以下の例1−4は、本発明による一般的な組成物を示す。組成物を製造する場合、それは、特に天然の形態の場合には、遊離酸または塩基を直接溶解するよりも、リポ酸またはアルギニンの塩を溶解するほうが有利である。アルギニンの余剰の比率は、安定性および許容可能な味に関与する。水は、優先的に10℃でなければならず、殺菌および脱気されていなければならない。アスコルビン酸のような酸化防止剤は、安定性を改善するために役立ち、味を改善しうる。外れた風味(off−flavours)は、残留する少量のいやな匂いを覆うことに寄与する。合成または生物由来の複合糖質は、いやな味を防ぐことに寄与する。
ケース1
37歳の男性は、勃起(陰茎の張力の減少)および性欲のわずかな減少の悪化に3ヵ月苦しんだ。検査によると、彼のIIEFカウントは9であった。全ての生化学的パラメータおよびホルモンは、正常範囲の範囲内であった。陰茎血管のドップラー断層撮影は正常であった。シルフェナディルによる負荷試験は陽性であり、そのため、勃起障害(ED)の器質的病理学は除外された。シルフェナディルの投与は重篤な顔面発赤を呼び起こし、患者に不快な感覚を引き起こした。検査後、心因性のEDと診断された。600mgのα−リポ酸の経口摂取は、IIEFスコアを変化させなかった。アルギニン(5g)および600mgのα−リポ酸は、性交前30分に経口摂取された。治療の後、勃起は正常化した。IIEFスコアは、9から21ポイントまで改善した。
23歳の男性は、不十分な勃起について1週間不満を感じた。男性は、18歳のときに性生活を始め、定期的に週に2回性交を行ってきた。3ヵ月前、彼は性的パートナーを変えた。新たなパートナーとの最初の性交で、彼は過度な興奮を経験した。その時から勃起は悪化し、IIEFスコアは8ポイントとなった。生化学的値およびホルモンの値は正常範囲内であった。診断は、心因性のEDおよび失敗予想症候群(failure expectation syndrome)であった。4gのアルギニンの経口摂取は、IIEFスコアを変化させなかった。また、性交前30分における600mgのα−リポ酸との併用による1gのアルギニンの摂取は、何れの改善ももたらさなかった。4gのアルギニンおよび300mgのα−リポ酸への変化の後、勃起は改善した。IIEFスコアは、8から12ポイントまで改善した。一方、患者は、毎日1gのアルギニン+100mgのα−リポ酸の常習的摂取に変更した。時折、彼は、性交前に付加的な4gのアルギニン+300mgのα−リポ酸を要求に応じて摂取した。
35歳の男性患者は、7年前から勃起の悪化に関して不満を感じていた。性交は、選択した位置でのみ可能であった。加えて、彼は早漏で苦しんだ。彼の性欲は完全なままだった。診断時のIEFFスコアは11であった。診断は身体的なEDおよび早漏であった。600mgのα−リポ酸が単一用量として投与し、アルギニンを1日にわたって4回の単一用量で2g与えた。勃起は改善し、性交は1−2分から7分まで長くなった。IEFFスコアは11から15ポイントまで変化した。4回の単一用量は、α−リポ酸との併用による10gのアルギニンの単一用量に変えられた。
44歳の患者(関連する精神的ストレスをもつ会社経営者)は、この13年間、低下した勃起および低下した性欲について不満を持っていた。朝の反応は維持していた。性的接触は、週に3回から月に3回の頻度であった。診断は、心因性のEDおよび経営者症候群(manager syndrome)であった。200mgのα−リポ酸の単一用量投与は何れの効果も奏せず、600mgへの増加が状況を改善した。しかしながら、5gのアルギニンとの併用による200mgのα−リポ酸は、完全に勃起を正常化した。IIEFスコアは、9から24ポイントまで改善した。常習的な摂取のために、アルギニンの一日量は、α−リポ酸の摂取の変更なく、2gまで低下した。
37歳の患者は、勃起および早漏の悪化について不満をもっていた。シルフェナディルおよびバルデナフィル(Verdenafil)の投与後、勃起は改善された;しかしながら、早漏はそのままであった。診断は心因性のEDおよび早漏であった。この基本的治療に加えて、10gのアルギニンを投与したが、何れの効果もなかった。しかしながら、10gのアルギニンとの併用による200mgのチオクト酸は、8から20ポイントまでIIEFの改善をもたらした。性交時間は、1分から4分まで延長された。
32歳の女性は、第一子の出産後、性欲の消失を経験した。性交は、唾液分泌(salivation)の減少のためにしばしば痛みを伴った。性欲の消失を感じて以来、彼女は少しのオルガスムも経験しなかった。2年前より、彼女は、彼女の夫の結婚カウンセリングに定期的に参加している。彼女は、一日当り3gのアルギニンの摂取を開始し10gまで増加したが、状況は改善しなかった。α−リポ酸の追加を、一日当り100mgから始めた。用量を毎週100mg増加させた。300mgのα−リポ酸を受けた後、彼女は第1の性欲の感覚を報告した。彼女は、現在、300gのα−リポ酸および5gのアルギニンを一緒に摂取しており、正しくオルガスムに達する能力を回復した。ISFS質問表は改善した(10ポイント)。彼女は、彼女のパートナーシップが改善したことを報告した。結婚カウンセリングは中止された。
55歳の男性は、5年前から、亜硝酸イソアミル(isoamylnitrite)の経鼻摂取後にだけ、性交を行うことが可能であった。しかしながら、性交は、予測不可能な勃起および早漏のためにまだ不満足だった。診断は、身体的な勃起障害および早漏であった。10gのアルギニンおよび600mgのα−リポ酸の摂取の導入の後、性交の典型的な時間を2分から5分まで延長することができ、亜硝酸アミル(amylnitrite)の用量は減らすことができた。アルギニン+α−リポ酸の常習的な摂取の間、組合せの摂取は、5g+300mgまで低下した。硝酸イソアミル(isoamylnitrate)の摂取は、もう必要としなくなった。
Claims (5)
- 性機能の改善または性障害の治療のための、NO供与体およびジチオランを含む経口摂取のための医薬組成物であって、前記NO供与体が、前記組成物中に存在するジチオランのモル量に基づいて過剰に存在し、前記NO供与体はL−アルギニンであり、前記ジチオランはR−α−リポ酸である医薬組成物。
- 請求項1に記載の医薬組成物であって、前記過剰が、ジチオランのモル量の2.1から50倍である医薬組成物。
- 請求項1または2に記載の医薬組成物であって、陰イオンジチオランとの関係における陽イオンNO供与体の過剰が、付加的な陰イオン塩パートナーによって補われる医薬組成物。
- 請求項1から3の何れか1項に記載の医薬組成物であって、アルギニンが200mgから15gの量で存在し、およびα−リポ酸が25mgから1200mgの量で存在する医薬組成物。
- 請求項1から4の何れか1項に記載の医薬組成物であって、アルギニンが500mgから10gの量で存在し、およびα−リポ酸が55mgから1200mgの量で存在する医薬組成物。
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Application Number | Priority Date | Filing Date | Title |
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EP05107206A EP1754478B1 (en) | 2005-08-04 | 2005-08-04 | Liquid Composition comprising arginine and alpha-lipoic acid and its use for improvement of sexual function |
EP05107206.4 | 2005-08-04 | ||
PCT/EP2006/007733 WO2007017191A2 (en) | 2005-08-04 | 2006-08-04 | Compositions comprising an no donor and a dithiolane and their use for improvement of sexual function |
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JP2008524446A Expired - Fee Related JP5295766B2 (ja) | 2005-08-04 | 2006-08-04 | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
JP2013038965A Active JP5925714B2 (ja) | 2005-08-04 | 2013-02-28 | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
JP2015233644A Pending JP2016104738A (ja) | 2005-08-04 | 2015-11-30 | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
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JP2015233644A Pending JP2016104738A (ja) | 2005-08-04 | 2015-11-30 | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
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US (1) | US9107889B2 (ja) |
EP (2) | EP1754478B1 (ja) |
JP (3) | JP5295766B2 (ja) |
CN (2) | CN102670591B (ja) |
AT (1) | ATE418976T1 (ja) |
BR (1) | BRPI0614434B8 (ja) |
CY (2) | CY1109430T1 (ja) |
DE (1) | DE602005012089D1 (ja) |
DK (2) | DK1754478T3 (ja) |
ES (2) | ES2320560T3 (ja) |
MX (1) | MX2008001554A (ja) |
PL (2) | PL1754478T3 (ja) |
PT (2) | PT1754478E (ja) |
RU (1) | RU2423120C2 (ja) |
SI (2) | SI1754478T1 (ja) |
UA (1) | UA95917C2 (ja) |
WO (1) | WO2007017191A2 (ja) |
Cited By (1)
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JP2013136616A (ja) * | 2005-08-04 | 2013-07-11 | Encrypta Gmbh | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
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FR2939042B1 (fr) * | 2008-11-28 | 2010-11-26 | Oreal | PROCEDE DE DEPIGMENTATION DES MATIERES KERATINIQUES A l'AIDE DE COMPOSES DITHIOLANNES. |
RU2458537C1 (ru) * | 2011-03-14 | 2012-08-20 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики эректильной дисфункции у мужчин |
FR3012039A1 (fr) * | 2013-10-22 | 2015-04-24 | Philippe Olivier Gorny | Medicament ou produit dietetique et son utilisation pour prevenir ou traiter les dysfonctionnements sexuels de l'homme et de la femme |
DK180173B1 (en) * | 2018-12-07 | 2020-07-14 | Inxo Ivs | Compositions for improving sexual function |
US11571405B2 (en) | 2018-12-07 | 2023-02-07 | Inxo A/S | Compositions for improving sexual function |
CN109876194B (zh) * | 2019-04-11 | 2021-04-02 | 湖北大学 | 一种可调节降解速率的poss-peg杂化水凝胶及其制备方法和其应用 |
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JP2013136616A (ja) * | 2005-08-04 | 2013-07-11 | Encrypta Gmbh | No供与体およびジチオランを含む組成物ならびに性機能の改善のためのそれらの使用 |
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