JP5280600B2 - 分裂中の細胞を破壊するための方法および装置 - Google Patents
分裂中の細胞を破壊するための方法および装置 Download PDFInfo
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- JP5280600B2 JP5280600B2 JP2001560365A JP2001560365A JP5280600B2 JP 5280600 B2 JP5280600 B2 JP 5280600B2 JP 2001560365 A JP2001560365 A JP 2001560365A JP 2001560365 A JP2001560365 A JP 2001560365A JP 5280600 B2 JP5280600 B2 JP 5280600B2
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- Prior art keywords
- electric field
- cells
- cell
- potential
- dividing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/147—Electrodes transferring energy by capacitive coupling, i.e. with a dielectricum between electrode and target tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18329500P | 2000-02-17 | 2000-02-17 | |
| US60/183,295 | 2000-02-17 | ||
| PCT/IB2001/000202 WO2001060994A1 (en) | 2000-02-17 | 2001-02-16 | Method and apparatus for destroying dividing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004505604A JP2004505604A (ja) | 2004-02-26 |
| JP2004505604A5 JP2004505604A5 (https=) | 2011-08-04 |
| JP5280600B2 true JP5280600B2 (ja) | 2013-09-04 |
Family
ID=22672230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001560365A Expired - Lifetime JP5280600B2 (ja) | 2000-02-17 | 2001-02-16 | 分裂中の細胞を破壊するための方法および装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | USRE43618E1 (https=) |
| EP (2) | EP2335776A1 (https=) |
| JP (1) | JP5280600B2 (https=) |
| CN (1) | CN1416466A (https=) |
| AU (1) | AU3399801A (https=) |
| CA (1) | CA2400526C (https=) |
| WO (1) | WO2001060994A1 (https=) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7890183B2 (en) | 2000-02-17 | 2011-02-15 | Novocure Ltd. | Treating parasites with electric fields |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| JP5280600B2 (ja) | 2000-02-17 | 2013-09-04 | パルティ、ヨーラム | 分裂中の細胞を破壊するための方法および装置 |
| CA2563817C (en) | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| ES2344215T3 (es) | 2004-12-07 | 2010-08-20 | Standen Ltd. | Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo. |
| EP3666328B1 (en) | 2004-12-27 | 2022-04-06 | Novocure GmbH | Treating a tumor or the like with electric fields at different orientations |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| WO2008034103A2 (en) * | 2006-09-14 | 2008-03-20 | Lazure Technologies, Llc | Device and method for destruction of cancer cells |
| KR20100014439A (ko) * | 2007-02-16 | 2010-02-10 | 아이오제닉 피티와이 엘티디 | 수생유기체의 배양을 향상시키는 방법 |
| US8465533B2 (en) | 2007-03-06 | 2013-06-18 | Novocure Limited | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| US8562602B2 (en) * | 2007-09-14 | 2013-10-22 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
| CN105232148A (zh) * | 2007-09-14 | 2016-01-13 | 拉热尔技术有限公司 | 前列腺癌消融 |
| US20090076500A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
| US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
| US8728139B2 (en) | 2009-04-16 | 2014-05-20 | Lazure Technologies, Llc | System and method for energy delivery to a tissue using an electrode array |
| US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| US9031701B2 (en) | 2011-02-15 | 2015-05-12 | Hemosonics Llc | Characterization of blood hemostasis and oxygen transport parameters |
| US9789328B2 (en) * | 2012-10-26 | 2017-10-17 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistent low strength magnetic field |
| US9757582B2 (en) * | 2012-10-26 | 2017-09-12 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistant low strength magnetic field |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US9833617B2 (en) | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US20180001075A1 (en) | 2016-06-30 | 2018-01-04 | Novocure Limited | Arrays for Longitudinal Delivery of TTFields to a Body |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| CO2018001283A1 (es) | 2018-02-07 | 2019-08-09 | Panacea Quantum Leap Tech Llc | Método de estimulación de tejidos con campos eléctricos y magnéticos por barrido en frecuencia |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| US11298422B2 (en) | 2018-04-09 | 2022-04-12 | Novocure Gmbh | Treating tumors with TTFields and an aurora kinase inhibitor |
| WO2019197999A1 (en) | 2018-04-10 | 2019-10-17 | Zeev Bomzon | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| KR102870236B1 (ko) | 2018-07-03 | 2025-10-14 | 에드윈 창 | 세포막 투과성을 향상시키기 위한 교류 전기장 사용 |
| BR112020025692A2 (pt) | 2018-07-10 | 2021-03-16 | Novocure Gmbh | Inibição de infecção viral usando campos elétricos alternados |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| EP3967361A1 (en) | 2018-07-18 | 2022-03-16 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields |
| DK3804648T3 (da) | 2018-08-23 | 2022-04-11 | Novocure Gmbh | Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3846894B8 (en) | 2018-09-07 | 2025-06-18 | Novocure GmbH | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| PL3984590T3 (pl) | 2018-10-15 | 2023-05-02 | Novocure Gmbh | Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu |
| CN112955208B (zh) * | 2018-10-25 | 2024-11-22 | 诺沃库勒有限责任公司 | 向受试者的脊柱解剖结构递送交变电场(例如,ttfields)的方法 |
| EP3880299B1 (en) | 2018-11-13 | 2025-09-24 | The Methodist Hospital | Device for oncomagnetic treatment |
| CN113015553B (zh) | 2018-11-19 | 2025-01-14 | 诺沃库勒有限责任公司 | 用于递送具有选择性可寻址子元件的肿瘤治疗场(TTField)的阵列 |
| BR112021004336A2 (pt) | 2018-11-29 | 2021-08-17 | Novocure Gmbh | matrizes de transdutor com flexibilidade melhorada para entregar ttfields (campos de tratamento de tumor) |
| EP3968279B1 (en) | 2019-01-08 | 2025-01-01 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
| EP4491214B1 (en) | 2019-02-27 | 2026-01-21 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| JP7419391B2 (ja) | 2019-03-29 | 2024-01-22 | ノボキュア ゲーエムベーハー | PTGER3阻害剤によりTTFields-耐性がん細胞におけるTTFieldsに対する感受性を回復させるための方法 |
| ES2940749T3 (es) | 2019-04-17 | 2023-05-11 | Novocure Gmbh | Carga de datos desde un sistema aislado sin comprometer el aislamiento |
| EP4480526A3 (en) | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| CN113766949B (zh) | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| CN113766950A (zh) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
| US11850422B2 (en) | 2019-04-23 | 2023-12-26 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| CN121314073A (zh) | 2019-07-31 | 2026-01-13 | 诺沃库勒有限责任公司 | 经由埋入颅骨植入物中的电极施加肿瘤治疗场(TTField) |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| CN114364433A (zh) | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场(TTFields) |
| JP7453355B2 (ja) | 2019-09-30 | 2024-03-19 | テーデーカー エレクトロニクス アーゲー | 多結晶セラミック固体、該固体による誘電体電極、該電極を備える装置及び製造方法 |
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| EP4099336B1 (en) | 2019-12-02 | 2025-06-18 | Novocure GmbH | Methods and apparatuses for optimizing transducer array placement |
| JP7747638B2 (ja) | 2019-12-31 | 2025-10-01 | ノボキュア ゲーエムベーハー | 電界分布の高速近似のための方法、システム、および装置 |
| US11941761B2 (en) | 2019-12-31 | 2024-03-26 | Novocure Gmbh | Methods, systems, and apparatuses for image segmentation |
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| CN121695416A (zh) | 2019-12-31 | 2026-03-20 | 诺沃库勒有限责任公司 | 具有可单独访问的电极元件和温度传感器的用于传递肿瘤治疗场(tt场)的阵列 |
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| BR112022021484A2 (pt) | 2020-04-24 | 2022-12-13 | Novocure Gmbh | Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica |
| WO2021223684A1 (zh) * | 2020-05-02 | 2021-11-11 | 电冷科学有限公司 | 一种避免活性非消融电极附近组织损伤的装置 |
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| CA3187793A1 (en) * | 2020-08-03 | 2022-02-10 | Novocure Gmbh | Compositions and methods for increasing cancer cell sensitivity to alternating electric fields |
| CN114075508A (zh) * | 2020-08-14 | 2022-02-22 | 上海必修福企业管理有限公司 | 电场发生装置及其在影响细胞的分裂周期中的用途和方法 |
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| EP4282465B1 (en) | 2020-12-21 | 2025-07-23 | Novocure GmbH | Optimization of composite electrode |
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| US12440680B2 (en) | 2021-03-12 | 2025-10-14 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| EP4480527B1 (en) | 2021-03-12 | 2025-11-05 | Novocure GmbH | An electrode array |
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| EP4284489B1 (en) | 2021-03-31 | 2025-07-16 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| WO2023275749A1 (en) | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using capacitors to regulate current in transducer arrays for applying tumor treating fields (ttfields) |
| EP4344413B1 (en) | 2021-07-21 | 2025-05-28 | Novocure GmbH | Conductive pad generating tumor treating field |
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| WO2023042080A1 (en) | 2021-09-14 | 2023-03-23 | Novocure Gmbh | Temperature independent method and system for applying ttfields |
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| US12434051B2 (en) | 2021-12-10 | 2025-10-07 | Novocure Gmbh | Compression garment assembly for applying TTFields and methods of production and use thereof |
| US20230173265A1 (en) | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| MX2024006036A (es) | 2021-12-14 | 2024-06-05 | Novocure Gmbh | Desplazamiento de matriz de transductores para reducir la irritacion cutanea. |
| TW202333820A (zh) | 2021-12-29 | 2023-09-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺 |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド(ttfield)を使用した治療のためのパラメータ値の選択 |
| US12478779B2 (en) | 2022-03-29 | 2025-11-25 | Novocure Gmbh | Electrode array having a semi-liquid conductive gel |
| JP7710117B2 (ja) | 2022-03-30 | 2025-07-17 | ノボキュア ゲーエムベーハー | トランスデューサアレイをペアリングすることによる交流電場を用いた被験者の治療および電気感覚の軽減 |
| EP4460361B1 (en) | 2022-03-30 | 2025-03-19 | Novocure GmbH | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| US12420113B2 (en) | 2022-04-01 | 2025-09-23 | The Board Of Regents Of The University Of Texas System | Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy |
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| WO2026069265A1 (en) | 2024-09-30 | 2026-04-02 | Novocure Gmbh | Transducer array generating tumor treating field |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| DE2907013A1 (de) | 1978-02-24 | 1979-08-30 | American Med Syst | Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich |
| DE2813068A1 (de) | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) * | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) * | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| AU9027191A (en) * | 1990-11-05 | 1992-05-26 | Bsd Medical Corporation | Urethral inserted applicator for prostate hyperthermia |
| AU1672492A (en) * | 1991-05-03 | 1992-12-21 | University Technologies International Inc. | Biofilm reduction method |
| US5441532A (en) | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5697909A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | Methods and apparatus for surgical cutting |
| US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5458597A (en) * | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| WO1997004830A1 (en) | 1995-07-28 | 1997-02-13 | Gray James R | Use of a polarizing field to modify the efficacy of a bioactive agent |
| US5606971A (en) | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6043066A (en) | 1997-09-04 | 2000-03-28 | Mangano; Joseph A. | Cell separation using electric fields |
| US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| CA2364098C (en) | 1999-03-09 | 2010-11-16 | Thermage, Inc. | Apparatus and method for treatment of tissue |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7890183B2 (en) | 2000-02-17 | 2011-02-15 | Novocure Ltd. | Treating parasites with electric fields |
| JP5280600B2 (ja) | 2000-02-17 | 2013-09-04 | パルティ、ヨーラム | 分裂中の細胞を破壊するための方法および装置 |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| CA2563817C (en) | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| DE102004028156A1 (de) | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
| ES2344215T3 (es) | 2004-12-07 | 2010-08-20 | Standen Ltd. | Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo. |
| EP3666328B1 (en) | 2004-12-27 | 2022-04-06 | Novocure GmbH | Treating a tumor or the like with electric fields at different orientations |
| US20060282122A1 (en) | 2005-06-08 | 2006-12-14 | Yoram Palti | Treating cancer with electric fields that are guided to desired locations within a body |
| CN101321555B (zh) | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| US8465533B2 (en) | 2007-03-06 | 2013-06-18 | Novocure Limited | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
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2001
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- 2001-02-16 AU AU33998/01A patent/AU3399801A/en not_active Abandoned
- 2001-02-16 EP EP10012031A patent/EP2335776A1/en not_active Ceased
- 2001-02-16 WO PCT/IB2001/000202 patent/WO2001060994A1/en not_active Ceased
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- 2001-02-16 CA CA2400526A patent/CA2400526C/en not_active Expired - Lifetime
- 2001-02-16 EP EP01906036A patent/EP1259596A4/en not_active Ceased
- 2001-02-16 CN CN01806416A patent/CN1416466A/zh active Pending
- 2001-02-16 US US10/204,334 patent/US7333852B2/en not_active Ceased
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| EP1259596A4 (en) | 2004-12-22 |
| EP1259596A1 (en) | 2002-11-27 |
| WO2001060994A1 (en) | 2001-08-23 |
| US7333852B2 (en) | 2008-02-19 |
| CN1416466A (zh) | 2003-05-07 |
| EP2335776A1 (en) | 2011-06-22 |
| US20030150372A1 (en) | 2003-08-14 |
| CA2400526C (en) | 2013-04-23 |
| AU3399801A (en) | 2001-08-27 |
| USRE43618E1 (en) | 2012-08-28 |
| JP2004505604A (ja) | 2004-02-26 |
| CA2400526A1 (en) | 2001-08-23 |
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