CA2400526C - Method and apparatus for destroying dividing cells - Google Patents
Method and apparatus for destroying dividing cells Download PDFInfo
- Publication number
- CA2400526C CA2400526C CA2400526A CA2400526A CA2400526C CA 2400526 C CA2400526 C CA 2400526C CA 2400526 A CA2400526 A CA 2400526A CA 2400526 A CA2400526 A CA 2400526A CA 2400526 C CA2400526 C CA 2400526C
- Authority
- CA
- Canada
- Prior art keywords
- electric field
- cells
- dividing cells
- cell
- dividing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract description 56
- 230000005684 electric field Effects 0.000 claims abstract description 117
- 230000006378 damage Effects 0.000 claims abstract description 33
- 238000003776 cleavage reaction Methods 0.000 claims abstract description 24
- 230000007017 scission Effects 0.000 claims abstract description 24
- 230000003834 intracellular effect Effects 0.000 claims abstract description 21
- 230000031016 anaphase Effects 0.000 claims abstract description 11
- 230000001965 increasing effect Effects 0.000 claims abstract description 10
- 230000016853 telophase Effects 0.000 claims abstract description 10
- 230000033001 locomotion Effects 0.000 abstract description 12
- 230000004044 response Effects 0.000 abstract description 7
- 210000004027 cell Anatomy 0.000 description 202
- 210000001519 tissue Anatomy 0.000 description 53
- 206010028980 Neoplasm Diseases 0.000 description 30
- 239000012528 membrane Substances 0.000 description 29
- 230000008569 process Effects 0.000 description 23
- 210000004881 tumor cell Anatomy 0.000 description 22
- 238000011282 treatment Methods 0.000 description 17
- 210000005061 intracellular organelle Anatomy 0.000 description 13
- 230000032823 cell division Effects 0.000 description 11
- 210000000170 cell membrane Anatomy 0.000 description 11
- 210000003463 organelle Anatomy 0.000 description 10
- 210000000349 chromosome Anatomy 0.000 description 8
- 230000001419 dependent effect Effects 0.000 description 8
- 210000000805 cytoplasm Anatomy 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 238000002512 chemotherapy Methods 0.000 description 6
- 239000004020 conductor Substances 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 230000003211 malignant effect Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 108091060290 Chromatid Proteins 0.000 description 3
- 241000195493 Cryptophyta Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004718 centriole Anatomy 0.000 description 3
- 210000004756 chromatid Anatomy 0.000 description 3
- 230000021953 cytokinesis Effects 0.000 description 3
- 238000010291 electrical method Methods 0.000 description 3
- 238000004520 electroporation Methods 0.000 description 3
- 210000003722 extracellular fluid Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000002977 intracellular fluid Anatomy 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000031877 prophase Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 210000002257 embryonic structure Anatomy 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 210000000777 hematopoietic system Anatomy 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 235000012771 pancakes Nutrition 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 208000037803 restenosis Diseases 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 201000003076 Angiosarcoma Diseases 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 206010004593 Bile duct cancer Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000005243 Chondrosarcoma Diseases 0.000 description 1
- 201000009047 Chordoma Diseases 0.000 description 1
- 208000006332 Choriocarcinoma Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000009798 Craniopharyngioma Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
- 206010014967 Ependymoma Diseases 0.000 description 1
- 208000006168 Ewing Sarcoma Diseases 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 208000001258 Hemangiosarcoma Diseases 0.000 description 1
- 208000018142 Leiomyosarcoma Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000007054 Medullary Carcinoma Diseases 0.000 description 1
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 201000010133 Oligodendroglioma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 208000007641 Pinealoma Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000007452 Plasmacytoma Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 201000010208 Seminoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000014070 Vestibular schwannoma Diseases 0.000 description 1
- 208000008383 Wilms tumor Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000004064 acoustic neuroma Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 201000007180 bile duct carcinoma Diseases 0.000 description 1
- 201000001531 bladder carcinoma Diseases 0.000 description 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000002230 centromere Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 208000002445 cystadenocarcinoma Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000004720 dielectrophoresis Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000037828 epithelial carcinoma Diseases 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003313 haploid nucleated cell Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000002222 hemangioblastoma Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 208000011379 keloid formation Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 206010024627 liposarcoma Diseases 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 208000037829 lymphangioendotheliosarcoma Diseases 0.000 description 1
- 208000012804 lymphangiosarcoma Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 208000001611 myxosarcoma Diseases 0.000 description 1
- 208000025189 neoplasm of testis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
- 201000010198 papillary carcinoma Diseases 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 208000024724 pineal body neoplasm Diseases 0.000 description 1
- 201000004123 pineal gland cancer Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 201000008407 sebaceous adenocarcinoma Diseases 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 201000010965 sweat gland carcinoma Diseases 0.000 description 1
- 206010042863 synovial sarcoma Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/147—Electrodes transferring energy by capacitive coupling, i.e. with a dielectricum between electrode and target tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18329500P | 2000-02-17 | 2000-02-17 | |
| US60/183,295 | 2000-02-17 | ||
| PCT/IB2001/000202 WO2001060994A1 (en) | 2000-02-17 | 2001-02-16 | Method and apparatus for destroying dividing cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2400526A1 CA2400526A1 (en) | 2001-08-23 |
| CA2400526C true CA2400526C (en) | 2013-04-23 |
Family
ID=22672230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2400526A Expired - Lifetime CA2400526C (en) | 2000-02-17 | 2001-02-16 | Method and apparatus for destroying dividing cells |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | USRE43618E1 (https=) |
| EP (2) | EP1259596A4 (https=) |
| JP (1) | JP5280600B2 (https=) |
| CN (1) | CN1416466A (https=) |
| AU (1) | AU3399801A (https=) |
| CA (1) | CA2400526C (https=) |
| WO (1) | WO2001060994A1 (https=) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7805201B2 (en) | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| CN1416466A (zh) | 2000-02-17 | 2003-05-07 | 约朗姆·帕尔蒂 | 破坏正在分裂的细胞的方法和装置 |
| DE602005020504D1 (de) | 2004-12-07 | 2010-05-20 | Standen Ltd | Vivo über einen längeren zeitraum |
| CA2594231C (en) * | 2004-12-27 | 2016-04-19 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| US20070021803A1 (en) * | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| JP5457183B2 (ja) | 2006-09-14 | 2014-04-02 | ラジュール・テクノロジーズ・エルエルシイ | 癌細胞を破壊する装置及び方法 |
| KR20100014439A (ko) * | 2007-02-16 | 2010-02-10 | 아이오제닉 피티와이 엘티디 | 수생유기체의 배양을 향상시키는 방법 |
| DK2167194T3 (en) | 2007-03-06 | 2017-06-19 | Novocure Ltd | TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY |
| EP2183024B1 (en) * | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
| WO2009036459A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
| WO2009036457A1 (en) | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
| CA2699782C (en) * | 2007-09-14 | 2017-04-11 | Lazure Technologies, Llc | Prostate cancer ablation |
| US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
| US8728139B2 (en) | 2009-04-16 | 2014-05-20 | Lazure Technologies, Llc | System and method for energy delivery to a tissue using an electrode array |
| US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| WO2013105987A2 (en) | 2011-02-15 | 2013-07-18 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| WO2014066765A1 (en) * | 2012-10-26 | 2014-05-01 | Sandstrom Robert E | Tumor treatment with free radical lifetimes enhanced by persistant low strength magnetic field |
| US9789328B2 (en) * | 2012-10-26 | 2017-10-17 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistent low strength magnetic field |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US9833617B2 (en) | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| JP6980706B2 (ja) | 2016-06-30 | 2021-12-15 | ノボキュア ゲーエムベーハー | 身体への腫瘍治療電場の長手方向伝達用のアレイ |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| CO2018001283A1 (es) | 2018-02-07 | 2019-08-09 | Panacea Quantum Leap Tech Llc | Método de estimulación de tejidos con campos eléctricos y magnéticos por barrido en frecuencia |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| JP7139448B2 (ja) | 2018-04-09 | 2022-09-20 | ノボキュア ゲーエムベーハー | ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療 |
| PL3775956T3 (pl) | 2018-04-10 | 2022-10-10 | Novocure Gmbh | Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji |
| CN114082099A (zh) | 2018-07-03 | 2022-02-25 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| CA3103070C (en) | 2018-07-10 | 2024-01-09 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| BR112020025269A2 (pt) | 2018-07-18 | 2021-03-09 | Novocure Gmbh | Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields) |
| JP6974671B2 (ja) | 2018-08-23 | 2021-12-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を向上させるための交流電界の使用 |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| WO2020049482A1 (en) | 2018-09-07 | 2020-03-12 | Yaniv Alon | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| CN112930209B (zh) | 2018-10-15 | 2024-10-15 | 诺沃库勒有限责任公司 | 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法 |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達 |
| WO2020102312A1 (en) | 2018-11-13 | 2020-05-22 | The Methodist Hospital | Method and apparatus for oncomagnetic treatement |
| WO2020104921A1 (en) | 2018-11-19 | 2020-05-28 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
| CN113164745B (zh) | 2018-11-29 | 2024-04-26 | 诺沃库勒有限责任公司 | 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列 |
| JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
| CN113573774B (zh) | 2019-02-26 | 2026-03-06 | 诺沃库勒有限责任公司 | 基于靶向癌细胞的电特性确定TTfield治疗的频率 |
| JP2022522936A (ja) | 2019-02-27 | 2022-04-21 | ノボキュア ゲーエムベーハー | 埋込可能な変換器アレイを使用した腫瘍治療電場（ｔｔｆｉｅｌｄｓ）の送達 |
| EP3988099B1 (en) | 2019-03-29 | 2023-06-07 | Novocure GmbH | Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors |
| US11291837B2 (en) | 2019-04-17 | 2022-04-05 | Novocure Gmbh | Uploading data from an isolated system without compromising isolation |
| US12109412B2 (en) | 2019-04-22 | 2024-10-08 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| CN113727753B (zh) | 2019-04-22 | 2024-09-13 | 波士顿科学国际有限公司 | 用于癌症治疗的电刺激装置 |
| WO2020219337A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Systems for administering electrical stimulation to treat cancer |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| US11712561B2 (en) | 2019-04-23 | 2023-08-01 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
| WO2020219519A1 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
| JP7472264B2 (ja) | 2019-07-31 | 2024-04-22 | ノボキュア ゲーエムベーハー | 頭蓋骨インプラントに埋め込まれた電極による腫瘍治療電場（ｔｔフィールド）の印加 |
| US12343336B2 (en) | 2019-08-05 | 2025-07-01 | Novocure Gmbh | Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity |
| JP2022545794A (ja) | 2019-08-30 | 2022-10-31 | ノボキュア ゲーエムベーハー | 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加 |
| CN114391006A (zh) | 2019-09-30 | 2022-04-22 | Tdk电子股份有限公司 | 多晶陶瓷固体、具有该固体的介电电极、具有该电极的装置及制造方法 |
| WO2021092402A1 (en) | 2019-11-08 | 2021-05-14 | Novocure Gmbh | Perforated hydrogel configurations and methods of production and use thereof |
| EP4070326B1 (en) | 2019-12-02 | 2025-06-18 | Novocure GmbH | Methods and apparatuses for optimizing transducer array placement |
| JP7677979B2 (ja) | 2019-12-31 | 2025-05-15 | ノボキュア ゲーエムベーハー | 画像セグメンテーションのための方法、システム、および装置 |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| MX2022006136A (es) | 2019-12-31 | 2022-06-17 | Novocure Gmbh | Matrices para suministrar campos de tratamiento de tumores (ttfields) con elementos de electrodos y sensores de temperatura accesibles individualmente. |
| US12367961B2 (en) | 2019-12-31 | 2025-07-22 | Novocure Gmbh | Methods, systems, and apparatuses for fast approximation of electric field distribution |
| JP7670721B6 (ja) | 2019-12-31 | 2025-06-06 | ノボキュア ゲーエムベーハー | 振幅調整およびチャネルの切り替え中のスパイクを防止する高電圧、高効率正弦波発生器 |
| WO2021150877A1 (en) | 2020-01-22 | 2021-07-29 | Novocure Gmbh | Assemblies containing two conductive gel compositions and methods of production and use thereof |
| CN115515674A (zh) | 2020-02-24 | 2022-12-23 | 波士顿科学国际有限公司 | 用于治疗胰腺癌的系统和方法 |
| WO2021198864A1 (en) | 2020-03-30 | 2021-10-07 | Novocure Gmbh | Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases |
| MX2022010015A (es) | 2020-04-24 | 2022-09-05 | Novocure Gmbh | Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica. |
| WO2021223684A1 (zh) * | 2020-05-02 | 2021-11-11 | 电冷科学有限公司 | 一种避免活性非消融电极附近组织损伤的装置 |
| TW202537657A (zh) | 2020-05-06 | 2025-10-01 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
| WO2021257967A1 (en) | 2020-06-19 | 2021-12-23 | The Methodist Hospital Dba Houston Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| IL299241A (en) * | 2020-08-03 | 2023-02-01 | Novocure Gmbh | Preparations and methods for increasing cancer cell sensitivity to alternating electric fields |
| CN114075508A (zh) * | 2020-08-14 | 2022-02-22 | 上海必修福企业管理有限公司 | 电场发生装置及其在影响细胞的分裂周期中的用途和方法 |
| WO2022064339A1 (en) | 2020-09-25 | 2022-03-31 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
| DE102020133165B9 (de) | 2020-12-11 | 2024-06-06 | Tdk Electronics Ag | Keramikelektrode, Baugruppe mit der Keramikelektrode, Anordnung mit der Keramikelektrode und Verfahren zur Herstellung einer Keramikelektrode |
| EP4282465B1 (en) | 2020-12-21 | 2025-07-23 | Novocure GmbH | Optimization of composite electrode |
| US12397151B2 (en) | 2021-02-17 | 2025-08-26 | Novocure Gmbh | Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas |
| EP4277693B1 (en) | 2021-03-12 | 2024-11-13 | Novocure Gmbh | Methods of production of an electrode array |
| JP2024509964A (ja) | 2021-03-12 | 2024-03-05 | ノボキュア ゲーエムベーハー | 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法 |
| EP4271466A2 (en) | 2021-03-18 | 2023-11-08 | Novocure Gmbh | Constructing a 3d phantom with liquid hydrogel |
| JP2024513854A (ja) | 2021-03-31 | 2024-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法 |
| KR20240027008A (ko) | 2021-06-30 | 2024-02-29 | 노보큐어 게엠베하 | 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용 |
| JP2024524745A (ja) | 2021-07-21 | 2024-07-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールドを発生させる伝導性パッド、ならびに、その生産および使用の方法 |
| US11877838B2 (en) * | 2021-08-14 | 2024-01-23 | Nano Hesgarsazan Salamat Arya | Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields |
| WO2023042080A1 (en) | 2021-09-14 | 2023-03-23 | Novocure Gmbh | Temperature independent method and system for applying ttfields |
| JP2024533808A (ja) | 2021-09-30 | 2024-09-12 | ノボキュア ゲーエムベーハー | 毛包と相互作用する腫瘍治療電場を印加するための方法およびシステム |
| US20230168242A1 (en) | 2021-11-29 | 2023-06-01 | Novocure Gmbh | Methods of Reducing Ciliogenesis with Alternating Electric Fields |
| US20230173288A1 (en) | 2021-12-07 | 2023-06-08 | Novocure Gmbh | Compact dc system for delivering a square wave ac signal |
| US12434051B2 (en) | 2021-12-10 | 2025-10-07 | Novocure Gmbh | Compression garment assembly for applying TTFields and methods of production and use thereof |
| US20230173265A1 (en) | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| WO2023105468A1 (en) | 2021-12-10 | 2023-06-15 | Novocure Gmbh | Compression garment assembly for applying ttfields and methods of production and use thereof |
| US12599765B2 (en) | 2021-12-14 | 2026-04-14 | Novocure Gmbh | Shifting of transducer array to reduce skin irritation |
| WO2023126842A1 (en) | 2021-12-29 | 2023-07-06 | Novocure Gmbh | Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択 |
| US12478779B2 (en) | 2022-03-29 | 2025-11-25 | Novocure Gmbh | Electrode array having a semi-liquid conductive gel |
| IL314392A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| CA3255022A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS |
| WO2023193012A2 (en) | 2022-04-01 | 2023-10-05 | The Board Of Regents Of The University Of Texas System | Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy |
| WO2023242741A1 (en) | 2022-06-13 | 2023-12-21 | Novocure Gmbh | Systems and methods for increasing intestinal absorption of therapeutic agents |
| EP4539924A1 (en) | 2022-06-20 | 2025-04-23 | Novocure GmbH | Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors |
| JP2025520663A (ja) | 2022-06-21 | 2025-07-03 | ノボキュア ゲーエムベーハー | 交流電場とｃｒｉｓｐｒ－ｃａｓシステムを用いた症状および疾患の治療システムおよび方法 |
| WO2024052877A1 (en) | 2022-09-08 | 2024-03-14 | Novocure Gmbh | Constructing a 3d phantom with a matrix material having conductive particles dispersed therein |
| JP2025536117A (ja) | 2022-09-27 | 2025-10-31 | ノボキュア ゲーエムベーハー | 内部ｔｔ場強度を測定するための摂取可能な植え込め型デバイス |
| CA3180284A1 (en) | 2022-09-29 | 2024-03-29 | Novocure Gmbh | Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment |
| JP2025532765A (ja) | 2022-09-29 | 2025-10-03 | ノボキュア ゲーエムベーハー | 電池交換中にｔｔ場を維持するためのシステムおよび方法 |
| EP4554658A1 (en) | 2022-09-30 | 2025-05-21 | Novocure Gmbh | Single wire temperature measurement solution for a ttfield application system and methods of production and use thereof |
| JP2025532790A (ja) | 2022-09-30 | 2025-10-03 | ノボキュア ゲーエムベーハー | 電気感覚および／または皮膚刺激を軽減するための組成物、システム、および方法 |
| CN119968209A (zh) | 2022-09-30 | 2025-05-09 | 诺沃库勒有限责任公司 | 使用交变电场和树突状细胞治疗癌症的组合物、系统和方法 |
| US20240108704A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using alternating electric fields and apoptotic cancer cell vaccination |
| CN115845254B (zh) * | 2022-11-23 | 2024-02-02 | 湖南安泰康成生物科技有限公司 | 小细胞肺癌治疗系统以及交变电场发生装置 |
| US20240173544A1 (en) | 2022-11-30 | 2024-05-30 | Novocure Gmbh | Transducer arrays having alternative array materials |
| WO2024127192A1 (en) | 2022-12-13 | 2024-06-20 | Novocure Gmbh | Wireless transducer arrays applying tumor treating fields and systems and methods of use thereof |
| WO2024141995A1 (en) | 2022-12-28 | 2024-07-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and anti-vegfr-2 antibodies |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN120936371A (zh) | 2023-03-30 | 2025-11-11 | 诺沃库勒有限责任公司 | 用于使用肿瘤治疗电场和嵌合抗原受体(car)免疫细胞治疗癌症的组合物、系统和方法 |
| CN120936370A (zh) | 2023-03-30 | 2025-11-11 | 诺沃库勒有限责任公司 | 用于使用肿瘤治疗电场和杀伤细胞治疗癌症的组合物、系统和方法 |
| WO2024201412A1 (en) | 2023-03-31 | 2024-10-03 | Novocure Gmbh | Microneedles to overcome contact resistance |
| US20240415869A1 (en) | 2023-06-15 | 2024-12-19 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and thioredoxin/glutathione inhibitors |
| WO2025062369A1 (en) | 2023-09-21 | 2025-03-27 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields with immune checkpoint inhibitors and mhc class i activators |
| CN121969417A (zh) | 2023-09-28 | 2026-05-01 | 诺沃库勒有限责任公司 | 具有子阵列的换能器阵列及其生产和使用方法 |
| CN121941528A (zh) | 2023-09-29 | 2026-04-28 | 诺沃库勒有限责任公司 | 将换能器阵列重新施加到患者的设备和方法 |
| CN121925295A (zh) | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉 |
| WO2025068877A1 (en) | 2023-09-29 | 2025-04-03 | Novocure Gmbh | Low frequency rf ablation system |
| US20250135196A1 (en) | 2023-10-27 | 2025-05-01 | Brown University | Compositions, systems, and methods for treating cancer using tumor treating fields with inhibitors of mif, mica, and/or micb |
| WO2025186743A1 (en) | 2024-03-05 | 2025-09-12 | Novocure Gmbh | Combinations for treating cancer in standard of care and/or profibrotic chemotherapeutic agent-naive patients using tumor treating fields and chemotherapeutic agents |
| US20250288820A1 (en) | 2024-03-15 | 2025-09-18 | Novocure Gmbh | Reduced impedance transducer array for applying alternating electric fields and methods of production and use thereof |
| US20250367138A1 (en) | 2024-05-31 | 2025-12-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and methylglyoxal |
| WO2026003783A1 (en) | 2024-06-27 | 2026-01-02 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and nf-κb inhibitors |
| WO2026033423A1 (en) | 2024-08-05 | 2026-02-12 | Novocure Gmbh | Flexible layer for use in a tumor treating fields transducer |
| US20260034376A1 (en) | 2024-08-05 | 2026-02-05 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer and foam layer |
| WO2026062559A1 (en) | 2024-09-20 | 2026-03-26 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and interferon gamma |
| WO2026069010A1 (en) | 2024-09-25 | 2026-04-02 | Novocure Gmbh | Compositions and systems for treating cancer using tumor treating fields (ttfields) and ace inhibitors |
| WO2026069112A1 (en) | 2024-09-26 | 2026-04-02 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields, chemotherapeutic agents, and anti-fibrotic agents |
| US20260091226A1 (en) | 2024-09-30 | 2026-04-02 | Novocure Gmbh | Transducer array generating tumor treating field and methods of production and use thereof |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| DE2907013A1 (de) | 1978-02-24 | 1979-08-30 | American Med Syst | Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich |
| DE2813068A1 (de) | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) * | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| WO1992007621A1 (en) * | 1990-11-05 | 1992-05-14 | Bsd Medical Corporation | Urethral inserted applicator for prostate hyperthermia |
| WO1992019286A1 (en) * | 1991-05-03 | 1992-11-12 | University Technologies International, Inc. | Biofilm reduction method |
| US5441532A (en) | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5697909A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | Methods and apparatus for surgical cutting |
| US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5458597A (en) * | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| WO1997004830A1 (en) | 1995-07-28 | 1997-02-13 | Gray James R | Use of a polarizing field to modify the efficacy of a bioactive agent |
| US5606971A (en) | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| EP1003847A4 (en) | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS |
| US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| WO2000053113A1 (en) | 1999-03-09 | 2000-09-14 | Thermage, Inc. | Apparatus and method for treatment of tissue |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| CN1416466A (zh) | 2000-02-17 | 2003-05-07 | 约朗姆·帕尔蒂 | 破坏正在分裂的细胞的方法和装置 |
| US7805201B2 (en) | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| DE102004028156A1 (de) | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
| DE602005020504D1 (de) | 2004-12-07 | 2010-05-20 | Standen Ltd | Vivo über einen längeren zeitraum |
| CA2594231C (en) | 2004-12-27 | 2016-04-19 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| DK1899001T3 (en) | 2005-06-08 | 2017-12-04 | Novocure Ltd | DEVICE FOR CANCER TREATMENT WITH ELECTRIC FIELDS MADE FOR DESIRED LOCATIONS IN A BODY |
| CN101321555B (zh) | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| DK2167194T3 (en) | 2007-03-06 | 2017-06-19 | Novocure Ltd | TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY |
| EP2183024B1 (en) | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
-
2001
- 2001-02-16 CN CN01806416A patent/CN1416466A/zh active Pending
- 2001-02-16 CA CA2400526A patent/CA2400526C/en not_active Expired - Lifetime
- 2001-02-16 EP EP01906036A patent/EP1259596A4/en not_active Ceased
- 2001-02-16 AU AU33998/01A patent/AU3399801A/en not_active Abandoned
- 2001-02-16 WO PCT/IB2001/000202 patent/WO2001060994A1/en not_active Ceased
- 2001-02-16 US US12/199,498 patent/USRE43618E1/en not_active Expired - Lifetime
- 2001-02-16 EP EP10012031A patent/EP2335776A1/en not_active Ceased
- 2001-02-16 JP JP2001560365A patent/JP5280600B2/ja not_active Expired - Lifetime
- 2001-02-16 US US10/204,334 patent/US7333852B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP5280600B2 (ja) | 2013-09-04 |
| US20030150372A1 (en) | 2003-08-14 |
| USRE43618E1 (en) | 2012-08-28 |
| US7333852B2 (en) | 2008-02-19 |
| EP1259596A4 (en) | 2004-12-22 |
| WO2001060994A1 (en) | 2001-08-23 |
| CN1416466A (zh) | 2003-05-07 |
| JP2004505604A (ja) | 2004-02-26 |
| EP2335776A1 (en) | 2011-06-22 |
| EP1259596A1 (en) | 2002-11-27 |
| AU3399801A (en) | 2001-08-27 |
| CA2400526A1 (en) | 2001-08-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2400526C (en) | Method and apparatus for destroying dividing cells | |
| US7016725B2 (en) | Method and apparatus for destroying dividing cells | |
| JP2004505604A5 (https=) | ||
| US7519420B2 (en) | Apparatus for selectively destroying dividing cells | |
| CA2563817C (en) | Treating a tumor or the like with electric fields at different frequencies | |
| EP2183024B1 (en) | Treating parasites with electric fields | |
| US7146210B2 (en) | Apparatus and method for optimizing tumor treatment efficiency by electric fields | |
| US8175698B2 (en) | Treating bacteria with electric fields | |
| US20060167499A1 (en) | Treating a tumor or the like with electric fields at different orientations | |
| HK1139089B (en) | Treating parasites with electric fields |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20210216 |