JP5268214B2 - ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調 - Google Patents

ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調 Download PDF

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JP5268214B2
JP5268214B2 JP2001517689A JP2001517689A JP5268214B2 JP 5268214 B2 JP5268214 B2 JP 5268214B2 JP 2001517689 A JP2001517689 A JP 2001517689A JP 2001517689 A JP2001517689 A JP 2001517689A JP 5268214 B2 JP5268214 B2 JP 5268214B2
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cpg
oligonucleotide
nucleoside
cpg dinucleotide
oligonucleotides
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JP2003526628A5 (enExample
JP2003526628A (ja
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サドヒル・アグラワル
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • AHUMAN NECESSITIES
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/18Type of nucleic acid acting by a non-sequence specific mechanism
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
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  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2001517689A 1999-08-13 2000-08-14 ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調 Expired - Fee Related JP5268214B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14879899P 1999-08-13 1999-08-13
US60/148,798 1999-08-13
PCT/US2000/022284 WO2001012804A2 (en) 1999-08-13 2000-08-14 MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES

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JP2010212544A Division JP2011019527A (ja) 1999-08-13 2010-09-22 ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調

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JP2003526628A JP2003526628A (ja) 2003-09-09
JP2003526628A5 JP2003526628A5 (enExample) 2006-01-05
JP5268214B2 true JP5268214B2 (ja) 2013-08-21

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JP2001517689A Expired - Fee Related JP5268214B2 (ja) 1999-08-13 2000-08-14 ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調
JP2010212544A Pending JP2011019527A (ja) 1999-08-13 2010-09-22 ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調

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US (1) US6476000B1 (enExample)
EP (2) EP2314693A3 (enExample)
JP (2) JP5268214B2 (enExample)
KR (1) KR100651294B1 (enExample)
AT (1) ATE286534T1 (enExample)
AU (2) AU783745B2 (enExample)
CA (2) CA2784789A1 (enExample)
DE (1) DE60017259T2 (enExample)
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MX (1) MXPA02001610A (enExample)
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DE60017259T2 (de) 2005-12-08
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CA2784789A1 (en) 2001-02-22
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