JP5260845B2 - 歯の美白方法 - Google Patents
歯の美白方法 Download PDFInfo
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- JP5260845B2 JP5260845B2 JP2006214702A JP2006214702A JP5260845B2 JP 5260845 B2 JP5260845 B2 JP 5260845B2 JP 2006214702 A JP2006214702 A JP 2006214702A JP 2006214702 A JP2006214702 A JP 2006214702A JP 5260845 B2 JP5260845 B2 JP 5260845B2
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Description
従って、本発明の課題は優れた美白効果と歯質強化効果を有する新たな歯の美白手段を提供することにある。
また、リン酸は歯の構成成分であり、リン酸およびその塩を加えることにより美白効果の制御が容易になるので、前述の酸と併用することが好ましい。リン酸の塩としては、ナトリウム、カリウム塩が好ましい。また、リン酸のほか、グリセロリン酸やグルコース−1−リン酸及びその塩も使用できる。
ここで、MFP等は歯の表面に付着した場合、水で洗口しても歯の表面に存在するので5秒〜30分の処理でよいが、前記の酸は水で洗口すると歯の表面から流出しやすいので、10分〜10時間、さらに30分〜5時間存在させるのが好ましい。このような時間歯の表面にこれらの成分を留めておくためには、前記各組成物の粘度を500〜10000dPa・s、さらに1000〜5000dPa・sとするのが好ましい。また、粘度が100dPa・s以下の場合は、脱脂綿、不織布、スポンジなどの吸水性のものに染み込ませて歯の表面に作用させることができる。
普通にハミガキを行い、歯に付着した汚れや歯垢を取り除く。その後、表1記載のジェル状組成物1を歯に適応するためのトレー(図1)に加え、空気が入らないように歯に装着し(図2)、2時間保持する。トレーを取り外し、歯の表面に残ったジェルを洗口により取り除く。これを1回/1日、10日間行い、試験前後の歯の表面を観察する。比較例として、表1の処方においてpHを6.0に調整した比較のジェル状組成物1(pH6)を用いて、同様の処理を行う。
ジェル状組成物1にて処理した歯の表面は、歯が白く、透明感が高く、内部から白くなっていた。一方、比較のジェル状組成物1(pH6)で処理した歯の表面はには十分な歯の美白効果は得られない。
ジェル状組成物2−1(表2)を1g以上歯ブラシに取り、2分間前歯を中心にまんべんなく塗布する。軽く水で洗口した後、図1のトレーにジェル状組成物2−2(表3)を入れ空気が入らないように歯に装着し、2時間保持する。トレーを取り外し、歯の表面に残ったジェルを洗口により取り除く。これを1回/1日、10日間行、試験前後の歯の表面を観察する。比較例として、ジェル状組成物2−1の後に、表3の処方でpH7.0に調整した比較のジェル状組成物2−2(pH7)を用いて同様の処理を行う。
ジェル状組成物2−2を用いて処理をした歯の表面は、歯が白く、透明感が高く、内部から白くなった。一方、比較のジェル状組成物2−2(pH7)を用いて同様の処理を行っても十分な歯の美白効果は得られない。
歯質強化作用を確認するため、歯質の溶解性(耐酸性)を測定した。
牛の歯各6本を用意し、実施例1と比較例1、実施例2と比較例2と同様の処理を行った。処理を行っていない時間は、進行唾液(サリベート、帝人製)に浸漬した。その後、未処理の対照群を加えた5種類のサンプルについて、pH4.5の0.1M乳酸緩衝液に2日間浸漬した。試験後の歯を400ミクロンの切片に加工し、レントゲン撮影を行った。写真より定法により歯のミネラル溶出量(Z(vol%*μm))を算出し、未処理品との差ポリオキシエチレンC14−C18アルキルリン酸エステルZ(vol%*μm)を得た。ΔZは値の小さいほど歯の溶出が抑制され、歯質が強化されていると判断できる。ΔZは次の文献に準じて求めた。
(Angmar B, Carlstrom D, Glas JE: Studies on the ultrastructure of dental enamel. IV The mineralization of normal human enamel. J Ultrastructure Res 8:12-33, 1963、Gelhard TB, Arends J: Microradiography of in vivo remineralized lesions in human enamel. II.J Biol Buccale. 12(1): 59-65, 1984)。結果を表4に示す。
Claims (5)
- 歯の表面を、モノフルオロリン酸又はその塩を含有し、かつモノフルオロリン酸又はその塩の含有量に対するモノフルオロリン酸又はその塩以外のフッ素供給化合物の含有量のモル比が1/2以下である組成物と、モノフルオロリン酸又はその塩とpKa2.5−6の有機酸とを含有し、モノフルオロリン酸又はその塩の含有量に対するモノフルオロリン酸又はその塩以外のフッ素供給化合物の含有量のモル比が1/2以下であり、かつpH4〜5.5である組成物で交互に処理するものである歯の美白方法。
- pKa2.5−6の有機酸が、乳酸、酢酸、クエン酸、リンゴ酸、コハク酸、酒石酸及びアジピン酸から選ばれる1種以上である請求項1に記載の歯の美白方法。
- 組成物中のモノフルオロリン酸又はその塩の含有量が、0.01〜5質量%である請求項1又は2に記載の歯の美白方法。
- 組成物中のpKa2.5−6の有機酸の含有量が、0.2〜10質量%である請求項1〜3のいずれか1項に記載の歯の美白方法。
- モノフルオロリン酸又はその塩を含有し、かつモノフルオロリン酸又はその塩の含有量に対するモノフルオロリン酸又はその塩以外のフッ素供給化合物の含有量のモル比が1/2以下である組成物、及び
モノフルオロリン酸又はその塩とpKa2.5−6の有機酸とを含有し、モノフルオロリン酸又はその塩の含有量に対するモノフルオロリン酸又はその塩以外のフッ素供給化合物の含有量のモル比が1/2以下であり、かつpH4〜5.5である組成物
からなる歯の美白剤。
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