JP5259305B2 - 細胞分析装置及び細胞分析方法 - Google Patents
細胞分析装置及び細胞分析方法 Download PDFInfo
- Publication number
- JP5259305B2 JP5259305B2 JP2008222537A JP2008222537A JP5259305B2 JP 5259305 B2 JP5259305 B2 JP 5259305B2 JP 2008222537 A JP2008222537 A JP 2008222537A JP 2008222537 A JP2008222537 A JP 2008222537A JP 5259305 B2 JP5259305 B2 JP 5259305B2
- Authority
- JP
- Japan
- Prior art keywords
- cell
- epithelial cells
- nucleus
- measurement sample
- fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004458 analytical method Methods 0.000 title claims description 40
- 210000004027 cell Anatomy 0.000 claims description 161
- 238000005259 measurement Methods 0.000 claims description 123
- 210000002919 epithelial cell Anatomy 0.000 claims description 51
- 238000012545 processing Methods 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 19
- 230000003287 optical effect Effects 0.000 claims description 19
- 230000002159 abnormal effect Effects 0.000 claims description 16
- 238000001514 detection method Methods 0.000 claims description 15
- 210000003679 cervix uteri Anatomy 0.000 claims description 8
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 210000004940 nucleus Anatomy 0.000 description 55
- 239000004065 semiconductor Substances 0.000 description 12
- 238000004590 computer program Methods 0.000 description 9
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 238000004891 communication Methods 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 230000032823 cell division Effects 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 238000001506 fluorescence spectroscopy Methods 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000003855 cell nucleus Anatomy 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Images
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008222537A JP5259305B2 (ja) | 2007-10-03 | 2008-08-29 | 細胞分析装置及び細胞分析方法 |
CN200810168323.6A CN101403739B (zh) | 2007-10-03 | 2008-09-26 | 细胞分析仪及细胞分析方法 |
EP08017313.1A EP2045595B1 (en) | 2007-10-03 | 2008-10-01 | Cell analyser and cell analysing method |
US12/286,702 US7800742B2 (en) | 2007-10-03 | 2008-10-01 | Cell analyzer and cell analyzing method |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007259777 | 2007-10-03 | ||
JP2007259777 | 2007-10-03 | ||
JP2008222537A JP5259305B2 (ja) | 2007-10-03 | 2008-08-29 | 細胞分析装置及び細胞分析方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009103687A JP2009103687A (ja) | 2009-05-14 |
JP2009103687A5 JP2009103687A5 (es) | 2011-09-29 |
JP5259305B2 true JP5259305B2 (ja) | 2013-08-07 |
Family
ID=40537815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008222537A Active JP5259305B2 (ja) | 2007-10-03 | 2008-08-29 | 細胞分析装置及び細胞分析方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5259305B2 (es) |
CN (1) | CN101403739B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4704519B2 (ja) * | 2009-06-12 | 2011-06-15 | オリンパス株式会社 | 被検体情報分析装置及び被検体情報分析方法 |
US8610085B2 (en) * | 2009-08-20 | 2013-12-17 | Bio-Rad Laboratories, Inc. | High-speed cellular cross sectional imaging |
JP2012047464A (ja) * | 2010-08-24 | 2012-03-08 | Sony Corp | 微小粒子測定装置及び光軸補正方法 |
JP5693894B2 (ja) | 2010-08-26 | 2015-04-01 | 日本光電工業株式会社 | 細胞解析装置及び細胞解析方法 |
JP2013024629A (ja) * | 2011-07-19 | 2013-02-04 | Sysmex Corp | フローサイトメータ |
JP5138801B2 (ja) | 2011-07-22 | 2013-02-06 | シスメックス株式会社 | 癌化情報提供方法および装置 |
JP5876359B2 (ja) * | 2012-03-30 | 2016-03-02 | シスメックス株式会社 | 癌化情報提供方法および癌化情報提供装置 |
JP5699118B2 (ja) * | 2012-11-14 | 2015-04-08 | シスメックス株式会社 | 細胞分析装置、癌化情報提供方法、dna量ヒストグラムの作成方法および検査方法 |
JP6001425B2 (ja) | 2012-11-26 | 2016-10-05 | シスメックス株式会社 | 血球分析方法、血球分析装置およびプログラム |
JP5892967B2 (ja) | 2013-03-29 | 2016-03-23 | シスメックス株式会社 | 細胞分析装置、細胞測定装置の管理方法およびコンピュータプログラム |
CN104297213B (zh) * | 2013-07-16 | 2017-10-03 | 成都深迈瑞医疗电子技术研究院有限公司 | 血液细胞分析仪及其异常细胞的识别方法与系统 |
JP6378599B2 (ja) * | 2013-10-11 | 2018-08-22 | シスメックス株式会社 | 細胞分析方法および細胞分析装置 |
EP3111193B1 (en) * | 2014-02-28 | 2020-02-26 | Life Technologies Corporation | Systems, methods, and apparatuses for optical systems in flow cytometers |
JP6116502B2 (ja) * | 2014-02-28 | 2017-04-19 | シスメックス株式会社 | 検体分析装置および検体分析方法 |
JP6238856B2 (ja) * | 2014-08-25 | 2017-11-29 | シスメックス株式会社 | 尿中異型細胞の分析方法、尿分析装置および体液中異型細胞の分析方法 |
EP3350569B1 (en) * | 2015-09-18 | 2023-07-19 | Redbud Labs, Inc. | Flow cells utilizing surface-attached structures, and related systems and methods |
JP6318184B2 (ja) * | 2016-01-20 | 2018-04-25 | シスメックス株式会社 | 細胞分析方法および細胞分析装置 |
KR102106384B1 (ko) * | 2016-06-07 | 2020-05-06 | 에센 인스트루먼츠, 인크. 디/비/에이/ 에센 바이오사이언스, 인크. | 유세포 분석 산란 파형 분석을 사용하여 샘플들 사이의 기포 검출을 위한 방법 |
JP6249049B2 (ja) * | 2016-06-14 | 2017-12-20 | ソニー株式会社 | 微小粒子測定装置 |
ES2919343T3 (es) * | 2017-05-25 | 2022-07-26 | Abbott Lab | Métodos y sistemas para el análisis de muestras |
AU2019242902B2 (en) | 2018-03-30 | 2021-10-28 | Idexx Laboratories, Inc. | Laser optics assembly of flow cytometer |
WO2021207894A1 (zh) * | 2020-04-13 | 2021-10-21 | 深圳迈瑞生物医疗电子股份有限公司 | 细胞分析方法、细胞分析仪及计算机可读存储介质 |
CN115015178A (zh) * | 2022-08-05 | 2022-09-06 | 天津迈科隆生物科技有限公司 | 一种光学检测装置及血液分析仪 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3290786B2 (ja) * | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
TW438973B (en) * | 1995-12-19 | 2001-06-07 | Sysmex Corp | Apparatus and method for analyzing solid components in urine |
JP3815838B2 (ja) * | 1997-03-13 | 2006-08-30 | シスメックス株式会社 | 粒子測定装置 |
JP4554810B2 (ja) * | 2000-12-21 | 2010-09-29 | シスメックス株式会社 | 粒子分析装置および粒子分析方法 |
EP1865303A1 (en) * | 2005-03-29 | 2007-12-12 | Sysmex Corporation | Method of discriminating cancer and atypical cells and cell analyzer |
-
2008
- 2008-08-29 JP JP2008222537A patent/JP5259305B2/ja active Active
- 2008-09-26 CN CN200810168323.6A patent/CN101403739B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
JP2009103687A (ja) | 2009-05-14 |
CN101403739B (zh) | 2014-08-06 |
CN101403739A (zh) | 2009-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5259305B2 (ja) | 細胞分析装置及び細胞分析方法 | |
US7800742B2 (en) | Cell analyzer and cell analyzing method | |
JP5739959B2 (ja) | 細胞分析装置及び細胞分析方法 | |
JP5537347B2 (ja) | 粒子分析装置 | |
US10208352B2 (en) | Providing cervical or oral mucosa canceration information from measurement of cells located toward the basal membrane side of epithelial tissue | |
JP2010085194A (ja) | 試料分析装置 | |
US20110104744A1 (en) | Cell analyzing apparatus and cell analyzing method | |
EP2784480A2 (en) | Blood cell analyzer and blood cell analyzing method | |
US9354161B2 (en) | Sample analyzing method and sample analyzer | |
EP2843409B1 (en) | Urine sample analyzing method and sample analyzer | |
JP5699118B2 (ja) | 細胞分析装置、癌化情報提供方法、dna量ヒストグラムの作成方法および検査方法 | |
JP2008241644A (ja) | 粒子分析装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110817 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110817 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120704 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120710 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120904 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20121016 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130116 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130305 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130402 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130424 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160502 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5259305 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |