JP5226926B2 - Ｈｅｒ３活性の阻害剤 - Google Patents

Ｈｅｒ３活性の阻害剤 Download PDF

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Publication number
JP5226926B2
JP5226926B2 JP2003518606A JP2003518606A JP5226926B2 JP 5226926 B2 JP5226926 B2 JP 5226926B2 JP 2003518606 A JP2003518606 A JP 2003518606A JP 2003518606 A JP2003518606 A JP 2003518606A JP 5226926 B2 JP5226926 B2 JP 5226926B2
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JP
Japan
Prior art keywords
her3
antibody
her2
cell line
inhibitor
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Expired - Lifetime
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JP2003518606A
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Japanese (ja)
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JP2005504044A5 (https=
JP2005504044A (ja
Inventor
ウルリッヒ アクセル
トゥン−ファン デア ホルスト エドゥワルト
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8178284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5226926(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of JP2005504044A publication Critical patent/JP2005504044A/ja
Publication of JP2005504044A5 publication Critical patent/JP2005504044A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003518606A 2001-08-09 2002-08-09 Ｈｅｒ３活性の阻害剤 Expired - Lifetime JP5226926B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01119260.6 2001-08-09
EP01119260A EP1283053A1 (en) 2001-08-09 2001-08-09 Inhibitors of HER3 activity
PCT/EP2002/008938 WO2003013602A1 (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity

Publications (3)

Publication Number Publication Date
JP2005504044A JP2005504044A (ja) 2005-02-10
JP2005504044A5 JP2005504044A5 (https=) 2013-01-17
JP5226926B2 true JP5226926B2 (ja) 2013-07-03

Family

ID=8178284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003518606A Expired - Lifetime JP5226926B2 (ja) 2001-08-09 2002-08-09 Ｈｅｒ３活性の阻害剤

Country Status (13)

Country Link
US (1) US9011851B2 (https=)
EP (3) EP1283053A1 (https=)
JP (1) JP5226926B2 (https=)
CN (2) CN1541109B (https=)
AT (1) ATE424219T1 (https=)
AU (1) AU2002333384B2 (https=)
CA (1) CA2456723C (https=)
CY (1) CY1110322T1 (https=)
DE (1) DE60231407D1 (https=)
DK (1) DK1414494T3 (https=)
ES (1) ES2323772T3 (https=)
PT (1) PT1414494E (https=)
WO (1) WO2003013602A1 (https=)

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* Cited by examiner, † Cited by third party
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EP2179291B1 (en) * 2007-07-13 2014-10-22 Nestec S.A. Drug selection for lung cancer therapy using antibody-based arrays
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Also Published As

Publication number Publication date
CN1541109B (zh) 2013-07-10
CA2456723C (en) 2016-02-09
EP2067792A2 (en) 2009-06-10
EP1414494B1 (en) 2009-03-04
CN1541109A (zh) 2004-10-27
US9011851B2 (en) 2015-04-21
CY1110322T1 (el) 2015-01-14
DE60231407D1 (de) 2009-04-16
ATE424219T1 (de) 2009-03-15
AU2002333384B2 (en) 2007-11-15
EP1283053A1 (en) 2003-02-12
JP2005504044A (ja) 2005-02-10
ES2323772T3 (es) 2009-07-24
CA2456723A1 (en) 2003-02-20
WO2003013602A1 (en) 2003-02-20
EP1414494A1 (en) 2004-05-06
US20040197332A1 (en) 2004-10-07
PT1414494E (pt) 2009-06-12
DK1414494T3 (da) 2009-07-06
CN102078613A (zh) 2011-06-01

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