JP5226926B2 - Ｈｅｒ３活性の阻害剤 - Google Patents

Ｈｅｒ３活性の阻害剤 Download PDF

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Publication number
JP5226926B2
JP5226926B2 JP2003518606A JP2003518606A JP5226926B2 JP 5226926 B2 JP5226926 B2 JP 5226926B2 JP 2003518606 A JP2003518606 A JP 2003518606A JP 2003518606 A JP2003518606 A JP 2003518606A JP 5226926 B2 JP5226926 B2 JP 5226926B2
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JP
Japan
Prior art keywords
her3
antibody
her2
cell line
inhibitor
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Expired - Lifetime
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JP2003518606A
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Japanese (ja)
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JP2005504044A5 (https=
JP2005504044A (ja
Inventor
ウルリッヒ アクセル
トゥン−ファン デア ホルスト エドゥワルト
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Publication of JP2005504044A5 publication Critical patent/JP2005504044A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003518606A 2001-08-09 2002-08-09 Ｈｅｒ３活性の阻害剤 Expired - Lifetime JP5226926B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01119260.6 2001-08-09
EP01119260A EP1283053A1 (en) 2001-08-09 2001-08-09 Inhibitors of HER3 activity
PCT/EP2002/008938 WO2003013602A1 (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity

Publications (3)

Publication Number Publication Date
JP2005504044A JP2005504044A (ja) 2005-02-10
JP2005504044A5 JP2005504044A5 (https=) 2013-01-17
JP5226926B2 true JP5226926B2 (ja) 2013-07-03

Family

ID=8178284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003518606A Expired - Lifetime JP5226926B2 (ja) 2001-08-09 2002-08-09 Ｈｅｒ３活性の阻害剤

Country Status (13)

Country Link
US (1) US9011851B2 (https=)
EP (3) EP1283053A1 (https=)
JP (1) JP5226926B2 (https=)
CN (2) CN1541109B (https=)
AT (1) ATE424219T1 (https=)
AU (1) AU2002333384B2 (https=)
CA (1) CA2456723C (https=)
CY (1) CY1110322T1 (https=)
DE (1) DE60231407D1 (https=)
DK (1) DK1414494T3 (https=)
ES (1) ES2323772T3 (https=)
PT (1) PT1414494E (https=)
WO (1) WO2003013602A1 (https=)

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* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
CA2456723A1 (en) 2003-02-20
CN1541109A (zh) 2004-10-27
AU2002333384B2 (en) 2007-11-15
CN102078613A (zh) 2011-06-01
PT1414494E (pt) 2009-06-12
CY1110322T1 (el) 2015-01-14
US9011851B2 (en) 2015-04-21
ATE424219T1 (de) 2009-03-15
DE60231407D1 (de) 2009-04-16
DK1414494T3 (da) 2009-07-06
EP1283053A1 (en) 2003-02-12
CN1541109B (zh) 2013-07-10
US20040197332A1 (en) 2004-10-07
EP1414494B1 (en) 2009-03-04
ES2323772T3 (es) 2009-07-24
EP1414494A1 (en) 2004-05-06
CA2456723C (en) 2016-02-09
WO2003013602A1 (en) 2003-02-20
EP2067792A2 (en) 2009-06-10
JP2005504044A (ja) 2005-02-10

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